EPOR and SH2B2

Number of citations of the paper that reports this interaction (PubMedID 10374881)
20

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		EPOR	SH2B2
Description		erythropoietin receptor	SH2B adaptor protein 2
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Nuclear Speck	Stress Fiber Ruffle Cytoplasm Cytosol Actin Filament Plasma Membrane
	Molecular Function	Erythropoietin Receptor Activity Protein Binding Identical Protein Binding	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Signaling Adaptor Activity SH2 Domain Binding Identical Protein Binding
	Biological Process	Signal Transduction Brain Development Heart Development Erythropoietin-mediated Signaling Pathway Decidualization	B-1 B Cell Homeostasis Nervous System Development Insulin Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Metabolic Process Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of Ras Protein Signal Transduction Antigen Receptor-mediated Signaling Pathway B Cell Receptor Signaling Pathway Brown Fat Cell Differentiation
Pathways		Signaling by Erythropoietin Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phospholipase C gamma (PLCG) Erythropoietin activates STAT5 Erythropoietin activates RAS Erythropoietin activates RAS	Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production
Drugs		Darbepoetin alfa Erythropoietin Dibromotyrosine Peginesatide Methoxy polyethylene glycol-epoetin beta
Diseases
GWAS		Coronary artery disease ( 29212778) Serum erythropoietin levels ( 30271932)	Hip circumference adjusted for BMI ( 34021172) Type 2 diabetes ( 31049640)
Interacting Genes		40 interacting genes: ATXN2L CBL CISH CRKL CSF2RB EGLN3 ELOB ELOC EPO GAB1 GAB2 GNAI1 GRAP GRB2 ICAM3 INPP5D IRS2 JAK2 KIT KITLG KLK3 LYN MAPK1 MAPK3 MST1R PIK3R1 PLCG1 PLCG2 PTPN11 PTPN6 RACK1 SH2B2 SHC1 SOCS2 SOCS3 STAT5A STAT5B SYK VAV1 VHL	43 interacting genes: AKT1 ASB6 BTK CBL CLK1 CLK3 DUSP13 EGFR EPOR ERBB2 ERBB4 FAM124B FAM90A1 FYN GRB2 HCK IL36RN INSR JADE2 JAK1 JAK2 JAK3 KIT LMO3 LYN MAGEH1 MCRS1 MET MTDH NTRK1 NTRK2 PDLIM7 PLEKHA3 RAB6B SH2B1 SHC1 SORBS1 SYK TLE5 TLNRD1 USP2 ZNF414 ZNF417
Entrez ID		2057	10603
HPRD ID		00587	16097
Ensembl ID		ENSG00000187266
Uniprot IDs		P19235	O14492
PDB IDs		1CN4 1EBA 1EBP 1EER 1ERN 2JIX 2MV6 4Y5V 4Y5X 4Y5Y 6E2Q 6MOE 6MOF 6MOH 6MOI 6MOJ 6MOK 6MOL	1Q2H
Enriched GO Terms of Interacting Partners?
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