EPOR and EPO

Number of citations of the paper that reports this interaction (PubMedID 9808045)
51

Data Source:
HPRD (in vivo)

		EPOR	EPO
Description		erythropoietin receptor	erythropoietin
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Nuclear Speck	Extracellular Region Extracellular Space Cell Surface Cell Body
	Molecular Function	Erythropoietin Receptor Activity Protein Binding Identical Protein Binding	Cytokine Activity Erythropoietin Receptor Binding Hormone Activity Protein Binding Protein Kinase Activator Activity
	Biological Process	Signal Transduction Brain Development Heart Development Erythropoietin-mediated Signaling Pathway Decidualization	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Apoptotic Process Acute-phase Response Signal Transduction Embryo Implantation Aging Blood Circulation Positive Regulation Of Cell Population Proliferation Response To Salt Stress Negative Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Neuron Projection Development Peptidyl-serine Phosphorylation Erythrocyte Differentiation Activation Of Protein Kinase Activity Response To Lipopolysaccharide Response To Vitamin A Response To Testosterone Erythropoietin-mediated Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Hemoglobin Biosynthetic Process Erythrocyte Maturation Response To Estrogen Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Ras Protein Signal Transduction Response To Axon Injury Response To Electrical Stimulus Response To Hyperoxia Positive Regulation Of ERK1 And ERK2 Cascade Response To Interleukin-1 Cellular Hyperosmotic Response Response To Dexamethasone Negative Regulation Of Neuron Death Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Negative Regulation Of Erythrocyte Apoptotic Process Negative Regulation Of Cation Channel Activity
Pathways		Signaling by Erythropoietin Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phospholipase C gamma (PLCG) Erythropoietin activates STAT5 Erythropoietin activates RAS Erythropoietin activates RAS	Regulation of gene expression by Hypoxia-inducible Factor Signaling by Erythropoietin Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phospholipase C gamma (PLCG) Erythropoietin activates STAT5 Erythropoietin activates RAS Erythropoietin activates RAS
Drugs		Darbepoetin alfa Erythropoietin Dibromotyrosine Peginesatide Methoxy polyethylene glycol-epoetin beta
Diseases
GWAS		Coronary artery disease ( 29212778) Serum erythropoietin levels ( 30271932)	Blood protein levels ( 30072576) Hematocrit ( 32888494 27863252 24777453) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693 24777453) Inflammatory bowel disease ( 23128233) LDL cholesterol levels ( 32203549) Other erythrocyte phenotypes ( 19862010) Plateletcrit ( 32888494) Pursuit maintenance gain in psychotic disorders ( 29064472) Red blood cell count ( 32888494 27863252) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		40 interacting genes: ATXN2L CBL CISH CRKL CSF2RB EGLN3 ELOB ELOC EPO GAB1 GAB2 GNAI1 GRAP GRB2 ICAM3 INPP5D IRS2 JAK2 KIT KITLG KLK3 LYN MAPK1 MAPK3 MST1R PIK3R1 PLCG1 PLCG2 PTPN11 PTPN6 RACK1 SH2B2 SHC1 SOCS2 SOCS3 STAT5A STAT5B SYK VAV1 VHL	3 interacting genes: EP300 EPOR HIF1A
Entrez ID		2057	2056
HPRD ID		00587	00586
Ensembl ID		ENSG00000187266	ENSG00000130427
Uniprot IDs		P19235	G9JKG7 P01588
PDB IDs		1CN4 1EBA 1EBP 1EER 1ERN 2JIX 2MV6 4Y5V 4Y5X 4Y5Y 6E2Q 6MOE 6MOF 6MOH 6MOI 6MOJ 6MOK 6MOL	1BUY 1CN4 1EER
Enriched GO Terms of Interacting Partners?
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