SH2B2 and DUSP13

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SH2B2	DUSP13
Description		SH2B adaptor protein 2	dual specificity phosphatase 13
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GO Annotations	Cellular Component	Stress Fiber Ruffle Cytoplasm Cytosol Actin Filament Plasma Membrane	Cytoplasm
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Signaling Adaptor Activity SH2 Domain Binding Identical Protein Binding	Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Phosphatase Activity MAP Kinase Phosphatase Activity Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	B-1 B Cell Homeostasis Nervous System Development Insulin Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Metabolic Process Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of Ras Protein Signal Transduction Antigen Receptor-mediated Signaling Pathway B Cell Receptor Signaling Pathway Brown Fat Cell Differentiation	Protein Dephosphorylation Spermatogenesis Dephosphorylation Peptidyl-tyrosine Dephosphorylation Negative Regulation Of MAPK Cascade Meiotic Cell Cycle
Pathways		Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172) Type 2 diabetes ( 31049640)	Blood protein levels ( 30072576 29875488) Body mass index ( 29273807) HDL cholesterol levels ( 32203549) Height ( 31562340)
Interacting Genes		43 interacting genes: AKT1 ASB6 BTK CBL CLK1 CLK3 DUSP13 EGFR EPOR ERBB2 ERBB4 FAM124B FAM90A1 FYN GRB2 HCK IL36RN INSR JADE2 JAK1 JAK2 JAK3 KIT LMO3 LYN MAGEH1 MCRS1 MET MTDH NTRK1 NTRK2 PDLIM7 PLEKHA3 RAB6B SH2B1 SHC1 SORBS1 SYK TLE5 TLNRD1 USP2 ZNF414 ZNF417	15 interacting genes: ACVR1 CALCOCO1 CARD9 CCDC85B CLU HOOK2 HSF2BP INCA1 LMNA PLEKHG4 SH2B2 SMURF1 TGFBR1 TRAF1 ZRANB1
Entrez ID		10603	51207
HPRD ID		16097	13251
Ensembl ID			ENSG00000079393
Uniprot IDs		O14492	Q6B8I1 Q9UII6
PDB IDs		1Q2H	2GWO 2PQ5 5XJV
Enriched GO Terms of Interacting Partners?
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