EPOR and GRAP

Number of citations of the paper that reports this interaction (PubMedID 8647802)
22

Data Source:
HPRD (in vivo, in vitro)

		EPOR	GRAP
Description		erythropoietin receptor	GRB2 related adaptor protein
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Nuclear Speck	Cytoplasm Cytosol Membrane Presynapse
	Molecular Function	Erythropoietin Receptor Activity Protein Binding Identical Protein Binding	Protein Binding
	Biological Process	Signal Transduction Brain Development Heart Development Erythropoietin-mediated Signaling Pathway Decidualization	Ras Protein Signal Transduction Cell-cell Signaling Sensory Perception Of Sound
Pathways		Signaling by Erythropoietin Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phospholipase C gamma (PLCG) Erythropoietin activates STAT5 Erythropoietin activates RAS Erythropoietin activates RAS	Signaling by SCF-KIT
Drugs		Darbepoetin alfa Erythropoietin Dibromotyrosine Peginesatide Methoxy polyethylene glycol-epoetin beta
Diseases
GWAS		Coronary artery disease ( 29212778) Serum erythropoietin levels ( 30271932)	Copper levels ( 26025379)
Interacting Genes		40 interacting genes: ATXN2L CBL CISH CRKL CSF2RB EGLN3 ELOB ELOC EPO GAB1 GAB2 GNAI1 GRAP GRB2 ICAM3 INPP5D IRS2 JAK2 KIT KITLG KLK3 LYN MAPK1 MAPK3 MST1R PIK3R1 PLCG1 PLCG2 PTPN11 PTPN6 RACK1 SH2B2 SHC1 SOCS2 SOCS3 STAT5A STAT5B SYK VAV1 VHL	19 interacting genes: ARHGAP32 DPPA4 EPOR FASLG FYN GAB2 KHDRBS1 KIT LAT LCK PLCG1 PRRG4 RAI1 RBPMS REL SHC1 SOS1 TOX TRIM21
Entrez ID		2057	10750
HPRD ID		00587	05062
Ensembl ID		ENSG00000187266	ENSG00000154016
Uniprot IDs		P19235	I3L2P9 Q13588
PDB IDs		1CN4 1EBA 1EBP 1EER 1ERN 2JIX 2MV6 4Y5V 4Y5X 4Y5Y 6E2Q 6MOE 6MOF 6MOH 6MOI 6MOJ 6MOK 6MOL
Enriched GO Terms of Interacting Partners?
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