SPRED2 and RBM48

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SPRED2	RBM48
Description		sprouty related EVH1 domain containing 2	RNA binding motif protein 48
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Transport Vesicle Membrane	Nucleoplasm
	Molecular Function	Stem Cell Factor Receptor Binding Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity	RNA Binding Protein Binding
	Biological Process	Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Catalytic Activity Negative Regulation Of MAPK Cascade Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Protein Deacetylation Negative Regulation Of Lens Fiber Cell Differentiation
Pathways		Regulation of RAS by GAPs FGFRL1 modulation of FGFR1 signaling RAS signaling downstream of NF1 loss-of-function variants
Drugs
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Body size at age 10 ( 32376654) Celiac disease or Rheumatoid arthritis ( 21383967) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cognitive decline rate in late mild cognitive impairment ( 26252872) Coronary artery disease ( 33020668) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Gamma glutamyl transferase levels ( 29403010 33339817) Glaucoma (primary open-angle) ( 33627673) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 27569725 23128233) Intraocular pressure ( 29617998) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Multiple sclerosis ( 31604244) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Psoriasis or type 2 diabetes (trans-disease meta-analysis) ( 33385400) Red blood cell count ( 32888494) Rheumatoid arthritis ( 30423114 24782177 23143596 24390342 20453842) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Severe influenza A (H1N1) infection ( 26379185) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 26502338) Systolic blood pressure ( 31647587) Tonsillectomy ( 27182965 28928442) Total cholesterol levels ( 30275531) White blood cell count ( 32888494 27863252)	Hip circumference adjusted for BMI ( 34021172) Idiopathic dilated cardiomyopathy ( 29495422)
Interacting Genes		30 interacting genes: AQP1 CTSD KCNIP1 KIT KPRP KRTAP12-2 KRTAP2-3 KRTAP2-4 LCE1C LCE2B LCE5A MDFI MTDH MYO15B NCS1 NDUFB7 QARS1 RBM48 RHOA RPS6KA6 SPG21 TOP3B TSNAX VSNL1 ZDHHC17 ZNF250 ZNF414 ZNF417 ZNF575 ZNF837	73 interacting genes: AMOT ANXA7 APLP1 ARMC7 ATPAF2 BID BTBD2 C11orf49 CCDC106 CCDC57 CDK5RAP2 CDKN1A CDKN2C COX17 COX5B EIF1AD ERH FAM118B FAM90A1 FXYD6 GADD45G GLYAT GSE1 GSTO1 GYS1 HSF2BP HSPB1 HSPB3 ID2 JMY KIF9 KPNA2 MAFG MAP7D1 MLH1 MLLT3 MNAT1 MPHOSPH6 NTAQ1 NUDT21 OSGEP PAFAH1B3 PCDHA4 PIBF1 PNP POLR1C PPP1R8 PRG2 PRKAB2 PSMD11 RAB27A RAD51D RFC5 RPA2 S100Z SAT1 SCNM1 SERPINB9 SH3GL3 SMN1 SPRED2 SULT1E1 TAF9 TBC1D22B TEKT4 TK1 TNFSF10 TRDMT1 TRIB3 TSR2 VIM WDR33 ZNF24
Entrez ID		200734	84060
HPRD ID		18100	13173
Ensembl ID		ENSG00000198369	ENSG00000127993
Uniprot IDs		B3KPL5 Q7Z698	Q5RL73
PDB IDs		2JP2
Enriched GO Terms of Interacting Partners?
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