SPRED2 and KRTAP2-3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SPRED2	KRTAP2-3
Description		sprouty related EVH1 domain containing 2	keratin associated protein 2-3
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Transport Vesicle Membrane	Cytosol Keratin Filament
	Molecular Function	Stem Cell Factor Receptor Binding Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity	Protein Binding
	Biological Process	Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Catalytic Activity Negative Regulation Of MAPK Cascade Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Protein Deacetylation Negative Regulation Of Lens Fiber Cell Differentiation
Pathways		Regulation of RAS by GAPs FGFRL1 modulation of FGFR1 signaling RAS signaling downstream of NF1 loss-of-function variants	Keratinization Keratinization
Drugs
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Body size at age 10 ( 32376654) Celiac disease or Rheumatoid arthritis ( 21383967) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cognitive decline rate in late mild cognitive impairment ( 26252872) Coronary artery disease ( 33020668) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Gamma glutamyl transferase levels ( 29403010 33339817) Glaucoma (primary open-angle) ( 33627673) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 27569725 23128233) Intraocular pressure ( 29617998) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Multiple sclerosis ( 31604244) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Psoriasis or type 2 diabetes (trans-disease meta-analysis) ( 33385400) Red blood cell count ( 32888494) Rheumatoid arthritis ( 30423114 24782177 23143596 24390342 20453842) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Severe influenza A (H1N1) infection ( 26379185) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 26502338) Systolic blood pressure ( 31647587) Tonsillectomy ( 27182965 28928442) Total cholesterol levels ( 30275531) White blood cell count ( 32888494 27863252)
Interacting Genes		30 interacting genes: AQP1 CTSD KCNIP1 KIT KPRP KRTAP12-2 KRTAP2-3 KRTAP2-4 LCE1C LCE2B LCE5A MDFI MTDH MYO15B NCS1 NDUFB7 QARS1 RBM48 RHOA RPS6KA6 SPG21 TOP3B TSNAX VSNL1 ZDHHC17 ZNF250 ZNF414 ZNF417 ZNF575 ZNF837	89 interacting genes: ADAMTSL3 BAHD1 BCL6B BEX2 C11orf87 CATSPER1 CHIC2 CREB5 CTSZ CXCL16 CYSRT1 DHX57 DMRT3 FAM161A GEMIN4 GGN HAPLN2 HHEX HOXA1 HOXB9 IGSF8 ITGB4 JOSD1 KLHL38 KRTAP1-1 KRTAP10-1 KRTAP12-4 KRTAP4-11 KRTAP4-12 KRTAP4-4 KRTAP5-11 KRTAP5-2 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1B LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3C LCE3D LNX1 MCRS1 MOBP NBPF19 NKD1 NOTCH2NLA NPDC1 NUFIP2 OTX1 P2RY6 PHLDA1 PIGS PRKAB2 RHBDL1 SDC3 SHFL SPATA3 SPRED2 TFAP2D TNP2 TRIM42 TTPA VASN VWC2 YY1 ZBTB24 ZDHHC1 ZIM2 ZNF165 ZNF264 ZNF440 ZNF491 ZNF524 ZNF564 ZNF575 ZNF578 ZNF581 ZNF587 ZNF672 ZNF764 ZNF786 ZNF792
Entrez ID		200734	730755
HPRD ID		18100
Ensembl ID		ENSG00000198369	ENSG00000212724
Uniprot IDs		B3KPL5 Q7Z698	P0C7H8 Q9BYR9
PDB IDs		2JP2
Enriched GO Terms of Interacting Partners?
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