SPRED2 and LCE2B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SPRED2	LCE2B
Description		sprouty related EVH1 domain containing 2	late cornified envelope 2B
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Transport Vesicle Membrane	Cellular_component
	Molecular Function	Stem Cell Factor Receptor Binding Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity	Molecular_function Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Catalytic Activity Negative Regulation Of MAPK Cascade Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Protein Deacetylation Negative Regulation Of Lens Fiber Cell Differentiation	Epidermis Development Keratinization
Pathways		Regulation of RAS by GAPs FGFRL1 modulation of FGFR1 signaling RAS signaling downstream of NF1 loss-of-function variants	Formation of the cornified envelope
Drugs
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Body size at age 10 ( 32376654) Celiac disease or Rheumatoid arthritis ( 21383967) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cognitive decline rate in late mild cognitive impairment ( 26252872) Coronary artery disease ( 33020668) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Gamma glutamyl transferase levels ( 29403010 33339817) Glaucoma (primary open-angle) ( 33627673) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 27569725 23128233) Intraocular pressure ( 29617998) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Multiple sclerosis ( 31604244) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Psoriasis or type 2 diabetes (trans-disease meta-analysis) ( 33385400) Red blood cell count ( 32888494) Rheumatoid arthritis ( 30423114 24782177 23143596 24390342 20453842) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Severe influenza A (H1N1) infection ( 26379185) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 26502338) Systolic blood pressure ( 31647587) Tonsillectomy ( 27182965 28928442) Total cholesterol levels ( 30275531) White blood cell count ( 32888494 27863252)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011)
Interacting Genes		30 interacting genes: AQP1 CTSD KCNIP1 KIT KPRP KRTAP12-2 KRTAP2-3 KRTAP2-4 LCE1C LCE2B LCE5A MDFI MTDH MYO15B NCS1 NDUFB7 QARS1 RBM48 RHOA RPS6KA6 SPG21 TOP3B TSNAX VSNL1 ZDHHC17 ZNF250 ZNF414 ZNF417 ZNF575 ZNF837	65 interacting genes: ADAMTSL4 CRCT1 CYSRT1 DHRS1 GRN GUCD1 HOXA1 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP26-1 KRTAP3-1 KRTAP3-3 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-2 KRTAP5-7 KRTAP5-9 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2C LCE2D LCE3A LCE3D LCE4A LCE5A MDFI NBPF19 NECTIN2 NOTCH2NLA NR4A3 OTX1 PLA2G10 PLAC8 PLSCR3 PLSCR4 RGS17 RGS20 RNF4 SPRED2 SPRY3 TGFB1 TRIM42 TSPAN4
Entrez ID		200734	26239
HPRD ID		18100	17260
Ensembl ID		ENSG00000198369	ENSG00000159455
Uniprot IDs		B3KPL5 Q7Z698	O14633
PDB IDs		2JP2
Enriched GO Terms of Interacting Partners?
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