SPRED2 and ZNF417

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SPRED2	ZNF417
Description		sprouty related EVH1 domain containing 2	zinc finger protein 417
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Transport Vesicle Membrane	Nucleus
	Molecular Function	Stem Cell Factor Receptor Binding Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Catalytic Activity Negative Regulation Of MAPK Cascade Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Protein Deacetylation Negative Regulation Of Lens Fiber Cell Differentiation	Regulation Of Transcription By RNA Polymerase II
Pathways		Regulation of RAS by GAPs FGFRL1 modulation of FGFR1 signaling RAS signaling downstream of NF1 loss-of-function variants	Generic Transcription Pathway
Drugs
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Body size at age 10 ( 32376654) Celiac disease or Rheumatoid arthritis ( 21383967) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cognitive decline rate in late mild cognitive impairment ( 26252872) Coronary artery disease ( 33020668) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Gamma glutamyl transferase levels ( 29403010 33339817) Glaucoma (primary open-angle) ( 33627673) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 27569725 23128233) Intraocular pressure ( 29617998) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Multiple sclerosis ( 31604244) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Psoriasis or type 2 diabetes (trans-disease meta-analysis) ( 33385400) Red blood cell count ( 32888494) Rheumatoid arthritis ( 30423114 24782177 23143596 24390342 20453842) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Severe influenza A (H1N1) infection ( 26379185) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 26502338) Systolic blood pressure ( 31647587) Tonsillectomy ( 27182965 28928442) Total cholesterol levels ( 30275531) White blood cell count ( 32888494 27863252)	Depression in smokers ( 30219690)
Interacting Genes		30 interacting genes: AQP1 CTSD KCNIP1 KIT KPRP KRTAP12-2 KRTAP2-3 KRTAP2-4 LCE1C LCE2B LCE5A MDFI MTDH MYO15B NCS1 NDUFB7 QARS1 RBM48 RHOA RPS6KA6 SPG21 TOP3B TSNAX VSNL1 ZDHHC17 ZNF250 ZNF414 ZNF417 ZNF575 ZNF837	169 interacting genes: - ADAMTSL4 AXIN2 BEGAIN BEND5 BEX3 BHLHB9 BICD2 C4orf17 CARD9 CBY2 CCDC125 CCDC136 CCDC57 CCDC85B CCNDBP1 CDR2 CDR2L CEP44 CEP70 CEP72 CEP85L CHRDL2 COG6 CSRNP1 CYSRT1 DEF8 DVL3 EFS EZHIP FAM221A FHL2 FHL3 FHL5 FRS3 FSD2 FXR1 GOLGA2 GOLGA6L9 HMBOX1 HOMEZ HOOK2 HOXA1 HSF2BP IGFBP6 IHO1 IKZF1 INKA1 JADE2 JRK KAT5 KATNBL1 KCTD7 KIF9 KIFC3 KLC3 KRT15 KRT31 KRT35 KRT38 KRT39 KRT40 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP5-9 KXD1 LHX3 LIMS1 LMO1 LURAP1 LZTS1 LZTS2 MAGEA8 MAST2 MCC MCCD1 MDFI MEIS3 MEOX2 MID2 MIIP MRFAP1L1 MTUS2 MYF5 MYLIP NAB2 NBPF19 NDEL1 NDUFB7 NINL NKAPL NKX3-1 NOTCH2NLA OIP5 PHC2 PICK1 PIH1D2 PLSCR1 PNMA2 PRICKLE4 PRPF31 RCN3 REL RHOQ RNF187 RORB RPGRIP1 RUNDC3A SH2B2 SMARCD1 SMYD5 SPRED1 SPRED2 SPRY1 SPRY2 SSX2IP STX11 SUV39H1 TADA2A TCF4 TEKT4 TFIP11 TLE5 TMCC2 TNS2 TRAF1 TRAF2 TRIB3 TRIM23 TRIM27 TRIM36 TRIM37 TRIM41 TRIM54 TSC1 TSGA10 TXNDC11 U2AF1 USHBP1 VPS16 VPS52 VWC2 ZBTB1 ZBTB10 ZBTB43 ZBTB8A ZBTB9 ZNF165 ZNF19 ZNF20 ZNF547 ZNF572 ZNF587 ZNF69 ZNF71 ZNF768 ZNF774 ZNF837 ZNF85 ZRANB1
Entrez ID		200734	147687
HPRD ID		18100	18341
Ensembl ID		ENSG00000198369	ENSG00000173480
Uniprot IDs		B3KPL5 Q7Z698	M0R230 Q8TAU3
PDB IDs		2JP2
Enriched GO Terms of Interacting Partners?
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