CSF1R and CTDSP1

Number of citations of the paper that reports this interaction (PubMedID 28065597)
37

Data Source:
BioGRID (two hybrid)

		CSF1R	CTDSP1
Description		colony stimulating factor 1 receptor	CTD small phosphatase 1
Image
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Intracellular Membrane-bounded Organelle Receptor Complex CSF1-CSF1R Complex	Nucleus Nucleoplasm Extracellular Exosome
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Macrophage Colony-stimulating Factor Receptor Activity Protein Binding ATP Binding Cytokine Binding Protein Homodimerization Activity	Phosphoprotein Phosphatase Activity Protein Binding RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Metal Ion Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Hematopoietic Progenitor Cell Differentiation Response To Ischemia Inflammatory Response Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Positive Regulation Of Macrophage Chemotaxis Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Hemopoiesis Monocyte Differentiation Macrophage Differentiation Osteoclast Differentiation Positive Regulation Of Cell Migration Ruffle Organization Positive Regulation Of Chemokine Production Positive Regulation Of Kinase Activity Cellular Response To Macrophage Colony-stimulating Factor Stimulus Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Innate Immune Response Regulation Of Bone Resorption Cell-cell Junction Maintenance Phosphatidylinositol Metabolic Process Protein Autophosphorylation Phosphatidylinositol-mediated Signaling Mammary Gland Duct Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Cytokine Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Macrophage Proliferation Positive Regulation Of Cell Motility Regulation Of Actin Cytoskeleton Reorganization	Negative Regulation Of Protein Phosphorylation Regulation Of Transcription By RNA Polymerase II Protein Dephosphorylation Negative Regulation Of Neuron Differentiation Negative Regulation Of Neurogenesis Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Other interleukin signaling Transcriptional Regulation by VENTX
Drugs		Imatinib Sunitinib ABT-869 5-CYANO-FURAN-2-CARBOXYLIC ACID [5-HYDROXYMETHYL-2-(4-METHYL-PIPERIDIN-1-YL)-PHENYL]-AMIDE 6-CHLORO-3-(3-METHYLISOXAZOL-5-YL)-4-PHENYLQUINOLIN-2(1H)-ONE Fostamatinib Erdafitinib Pexidartinib	Aspartate beryllium trifluoride Citric acid
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576 28240269) Granulocyte percentage of myeloid white cells ( 27863252) Hemoglobin levels ( 33491795) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494)	Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 23128233) Mean corpuscular hemoglobin concentration ( 32888494 27863252)
Interacting Genes		23 interacting genes: CBL CSF1 CTDSP1 CTDSP2 FYN GRAP2 GRB2 INPP5D INPPL1 KIT LAMC2 LYN PIK3CA PIK3R1 PIK3R2 RASA1 SHC1 SOCS1 SOCS3 SOS1 STAP2 THOC5 YES1	42 interacting genes: ACTN3 BAG3 CDCA3 CDKN2C CRYBA2 CSF1R CSTF2T FAAP20 FAM110A FANCL FGFR2 GPSM1 GTF2F1 ITPKB LCK LDB1 LRRC73 LTBP4 MAPKBP1 MBP MORN3 NOXA1 OSTF1 PDZD4 PLEKHM1 POLR2A PPP1R32 PTPN11 RAB3IL1 RPRD2 SCNM1 SDCBP SNAI1 STRA8 TEKT4 TRAPPC6A TYRO3 USP29 WWOX YPEL5 ZBTB16 ZSWIM8
Entrez ID		1436	58190
HPRD ID		01269	05615
Ensembl ID		ENSG00000182578	ENSG00000144579
Uniprot IDs		P07333	Q9GZU7
PDB IDs		2I0V 2I0Y 2I1M 2OGV 3BEA 3DPK 3KRJ 3KRL 3LCD 3LCO 4DKD 4HW7 4LIQ 4R7H 4R7I 4WRL 4WRM 6IG8 6N33 6T2W 6WXJ	1T9Z 1TA0 2GHQ 2GHT 3L0B 3L0C 3L0Y 3PGL 4YGY 4YH1 6DU3
Enriched GO Terms of Interacting Partners?
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