CSF1R and CSF1

Number of citations of the paper that reports this interaction (PubMedID 2408759)
327

Data Source:
HPRD (in vivo)

		CSF1R	CSF1
Description		colony stimulating factor 1 receptor	colony stimulating factor 1
Image
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Intracellular Membrane-bounded Organelle Receptor Complex CSF1-CSF1R Complex	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Membrane Integral Component Of Membrane Nuclear Body Perinuclear Region Of Cytoplasm CSF1-CSF1R Complex
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Macrophage Colony-stimulating Factor Receptor Activity Protein Binding ATP Binding Cytokine Binding Protein Homodimerization Activity	Cytokine Activity Macrophage Colony-stimulating Factor Receptor Binding Protein Binding Growth Factor Activity Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Hematopoietic Progenitor Cell Differentiation Response To Ischemia Inflammatory Response Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Positive Regulation Of Macrophage Chemotaxis Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Hemopoiesis Monocyte Differentiation Macrophage Differentiation Osteoclast Differentiation Positive Regulation Of Cell Migration Ruffle Organization Positive Regulation Of Chemokine Production Positive Regulation Of Kinase Activity Cellular Response To Macrophage Colony-stimulating Factor Stimulus Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Innate Immune Response Regulation Of Bone Resorption Cell-cell Junction Maintenance Phosphatidylinositol Metabolic Process Protein Autophosphorylation Phosphatidylinositol-mediated Signaling Mammary Gland Duct Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Cytokine Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Macrophage Proliferation Positive Regulation Of Cell Motility Regulation Of Actin Cytoskeleton Reorganization	Positive Regulation Of Cell-matrix Adhesion Osteoclast Proliferation Response To Ischemia Developmental Process Involved In Reproduction Inflammatory Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Macrophage Chemotaxis Macrophage Differentiation Regulation Of Ossification Osteoclast Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Mononuclear Cell Proliferation Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Multicellular Organism Growth Monocyte Activation Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Innate Immune Response Positive Regulation Of Macrophage Differentiation Positive Regulation Of Monocyte Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Ras Protein Signal Transduction Homeostasis Of Number Of Cells Within A Tissue Branching Involved In Mammary Gland Duct Morphogenesis Mammary Gland Fat Development Mammary Duct Terminal End Bud Growth Microglial Cell Proliferation Negative Regulation Of Neuron Death Positive Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Microglial Cell Migration Positive Regulation Of Macrophage Migration
Pathways		Other interleukin signaling Transcriptional Regulation by VENTX	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Other interleukin signaling Interleukin-10 signaling Post-translational protein phosphorylation
Drugs		Imatinib Sunitinib ABT-869 5-CYANO-FURAN-2-CARBOXYLIC ACID [5-HYDROXYMETHYL-2-(4-METHYL-PIPERIDIN-1-YL)-PHENYL]-AMIDE 6-CHLORO-3-(3-METHYLISOXAZOL-5-YL)-4-PHENYLQUINOLIN-2(1H)-ONE Fostamatinib Erdafitinib Pexidartinib
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576 28240269) Granulocyte percentage of myeloid white cells ( 27863252) Hemoglobin levels ( 33491795) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494)	Adult onset Still's disease ( 32149159) Aspartate aminotransferase levels ( 33547301 29403010 33339817) Blood protein levels in cardiovascular risk ( 28369058) Creatine kinase levels ( 29403010) Cryptococcosis in HIV infection ( 33269293) Height ( 31562340) High density lipoprotein cholesterol levels ( 33339817) Lactate dehydrogenase levels ( 29403010) Lymphocyte counts ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Paget's disease ( 21623375 20436471) Periventricular white matter hyperintensities ( 32517579) Platelet count ( 32888494) Plateletcrit ( 32888494) Sensory disturbances after bilateral sagittal split ramus osteotomy ( 23834954) Serum total protein level ( 29403010) Total body bone mineral density ( 29304378) White blood cell count ( 32888494 27863252)
Interacting Genes		23 interacting genes: CBL CSF1 CTDSP1 CTDSP2 FYN GRAP2 GRB2 INPP5D INPPL1 KIT LAMC2 LYN PIK3CA PIK3R1 PIK3R2 RASA1 SHC1 SOCS1 SOCS3 SOS1 STAP2 THOC5 YES1	13 interacting genes: CSF1R CYSRT1 FHL3 GAB3 HLA-B KRTAP1-1 KRTAP10-8 MTUS2 NOTCH2NLA SGTA SLA2 SOCS1 TNF
Entrez ID		1436	1435
HPRD ID		01269	00388
Ensembl ID		ENSG00000182578	ENSG00000184371
Uniprot IDs		P07333	A0A024R0A1 P09603
PDB IDs		2I0V 2I0Y 2I1M 2OGV 3BEA 3DPK 3KRJ 3KRL 3LCD 3LCO 4DKD 4HW7 4LIQ 4R7H 4R7I 4WRL 4WRM 6IG8 6N33 6T2W 6WXJ	1HMC 3UEZ 3UF2 4ADF 4FA8 4WRL 4WRM 5LXF
Enriched GO Terms of Interacting Partners?
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