CSF1R and SOCS1

Number of citations of the paper that reports this interaction (PubMedID 10022833)
33

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		CSF1R	SOCS1
Description		colony stimulating factor 1 receptor	suppressor of cytokine signaling 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Intracellular Membrane-bounded Organelle Receptor Complex CSF1-CSF1R Complex	Nucleoplasm Cytoplasm Cytosol Phosphatidylinositol 3-kinase Complex Cytoplasmic Vesicle Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Macrophage Colony-stimulating Factor Receptor Activity Protein Binding ATP Binding Cytokine Binding Protein Homodimerization Activity	Protein Kinase Inhibitor Activity Insulin-like Growth Factor Receptor Binding Protein Binding Kinase Inhibitor Activity Protein Kinase Binding 1-phosphatidylinositol-3-kinase Regulator Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Hematopoietic Progenitor Cell Differentiation Response To Ischemia Inflammatory Response Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Positive Regulation Of Macrophage Chemotaxis Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Hemopoiesis Monocyte Differentiation Macrophage Differentiation Osteoclast Differentiation Positive Regulation Of Cell Migration Ruffle Organization Positive Regulation Of Chemokine Production Positive Regulation Of Kinase Activity Cellular Response To Macrophage Colony-stimulating Factor Stimulus Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Innate Immune Response Regulation Of Bone Resorption Cell-cell Junction Maintenance Phosphatidylinositol Metabolic Process Protein Autophosphorylation Phosphatidylinositol-mediated Signaling Mammary Gland Duct Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Cytokine Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Macrophage Proliferation Positive Regulation Of Cell Motility Regulation Of Actin Cytoskeleton Reorganization	Regulation Of Cytokine Production Regulation Of Protein Phosphorylation Receptor Signaling Pathway Via JAK-STAT Regulation Of Activation Of Janus Kinase Activity Protein Ubiquitination Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Regulation Of Growth Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Catalytic Activity Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Negative Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Regulation Of Phosphatidylinositol 3-kinase Activity Fat Cell Differentiation Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol Phosphate Biosynthetic Process Regulation Of Interferon-gamma-mediated Signaling Pathway Cellular Response To Amino Acid Stimulus
Pathways		Other interleukin signaling Transcriptional Regulation by VENTX	Interleukin-7 signaling Regulation of KIT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Regulation of IFNG signaling Interferon alpha/beta signaling Regulation of IFNA signaling Signaling by CSF3 (G-CSF) Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Growth hormone receptor signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Imatinib Sunitinib ABT-869 5-CYANO-FURAN-2-CARBOXYLIC ACID [5-HYDROXYMETHYL-2-(4-METHYL-PIPERIDIN-1-YL)-PHENYL]-AMIDE 6-CHLORO-3-(3-METHYLISOXAZOL-5-YL)-4-PHENYLQUINOLIN-2(1H)-ONE Fostamatinib Erdafitinib Pexidartinib
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576 28240269) Granulocyte percentage of myeloid white cells ( 27863252) Hemoglobin levels ( 33491795) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494)	Allergy ( 27182965) Alopecia areata ( 25608926) Aspartate aminotransferase levels ( 33547301) Asthma ( 31959851 29273806) Bulimia nervosa ( 23568457) Celiac disease ( 20190752) Crohn's disease ( 28067908) Crohn's disease and psoriasis ( 22482804) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Inflammatory bowel disease ( 28067908 23128233) Multiple sclerosis ( 31604244) Primary biliary cholangitis ( 26394269) Primary biliary cirrhosis ( 22961000) Psoriasis ( 23143594) Psoriasis vulgaris ( 26626624) Systemic lupus erythematosus ( 27399966 26502338)
Interacting Genes		23 interacting genes: CBL CSF1 CTDSP1 CTDSP2 FYN GRAP2 GRB2 INPP5D INPPL1 KIT LAMC2 LYN PIK3CA PIK3R1 PIK3R2 RASA1 SHC1 SOCS1 SOCS3 SOS1 STAP2 THOC5 YES1	54 interacting genes: AXL BLK COMMD1 CRK CSF1 CSF1R CUEDC2 CXCR4 CYTIP EGFR ELOB ELOC ERBB2 ERBB4 FLT3 FYN GHR GRB2 IFNAR1 IFNGR1 IGF1R IL2RB INSR IRF7 IRS1 IRS2 ITK JAK1 JAK2 JAK3 KIT LCK LYN MET MIR924HG MPL NCK1 PDGFRB PIK3R1 PIK3R2 PIM2 PTK2 RELA SH3GL1 SRC TEC TEK TIRAP TP53 TRIM8 TYK2 VAV1 VAV2 YES1
Entrez ID		1436	8651
HPRD ID		01269	04669
Ensembl ID		ENSG00000182578	ENSG00000185338
Uniprot IDs		P07333	O15524 Q4JHT5
PDB IDs		2I0V 2I0Y 2I1M 2OGV 3BEA 3DPK 3KRJ 3KRL 3LCD 3LCO 4DKD 4HW7 4LIQ 4R7H 4R7I 4WRL 4WRM 6IG8 6N33 6T2W 6WXJ
Enriched GO Terms of Interacting Partners?
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