CRP and GLUD1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		CRP	GLUD1
Description		C-reactive protein	glutamate dehydrogenase 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytoplasm Mitochondrion Mitochondrial Matrix Endoplasmic Reticulum
	Molecular Function	Complement Component C1q Complex Binding Calcium Ion Binding Protein Binding Low-density Lipoprotein Particle Binding Choline Binding Identical Protein Binding Virion Binding Low-density Lipoprotein Particle Receptor Binding	Glutamate Dehydrogenase (NAD+) Activity Glutamate Dehydrogenase [NAD(P)+] Activity Glutamate Dehydrogenase (NADP+) Activity Protein Binding ATP Binding GTP Binding Identical Protein Binding ADP Binding NAD+ Binding Leucine Binding
	Biological Process	Acute-phase Response Inflammatory Response Complement Activation, Classical Pathway Opsonization Positive Regulation Of Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Regulation Of Interleukin-8 Production Positive Regulation Of Superoxide Anion Generation Negative Regulation Of Mononuclear Cell Proliferation Vasoconstriction Negative Regulation By Host Of Viral Process Innate Immune Response Defense Response To Gram-positive Bacterium	Glutamate Biosynthetic Process Glutamate Catabolic Process Glutamine Metabolic Process Substantia Nigra Development Positive Regulation Of Insulin Secretion Tricarboxylic Acid Metabolic Process
Pathways		Classical antibody-mediated complement activation	Transcriptional activation of mitochondrial biogenesis Glutamate and glutamine metabolism
Drugs		N,N,N-Trimethyl-2-(phosphonooxy)ethanaminium CRx-139	Glutamic acid NADH Hexachlorophene Guanosine-5'-Triphosphate Aluminum chloride
Diseases
GWAS		Blood protein levels ( 30072576 29875488 23696881) C-reactive protein ( 22492993 19567438 21647738 18439548 18439552 21196492 23844046 22939635) C-reactive protein levels ( 33227023 24763700 29403010 33339817 30388399 21300955 28548082) C-reactive protein levels in ischemic stroke ( 26718567) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Erythropoietin levels ( 33227023) High-sensitivity C-reactive protein levels in HIV infection ( 33095540) Inflammatory biomarkers ( 22291609) Inflammatory biomarkers in Kawasaki disease ( 25266886) Lung cancer ( 18385676) Metabolic traits ( 19060910) Protein quantitative trait loci ( 18464913) Select biomarker traits ( 17903293) Serum C-reactive protein concentration ( 32928877) Serum C-reactive protein concentration in obesity ( 32928877) Serum C-reactive protein concentration in visceral obesity (waist circumference) ( 32928877)	Renal underexcretion gout ( 32238385)
Interacting Genes		22 interacting genes: APCS C1QA CFH ESS2 FCGR1A FCGR2A FCGR2B FN1 GLUD1 GMPPA GP6 H1-1 H2AC16 H2AC20 LAMC3 LEP MAPK1 MAPK3 MAPK8IP2 RPL13A SNRNP70 UBE3A	13 interacting genes: ASGR2 CRP CTNNB1 DYNLL1 GOT2 HPX HSD17B10 LSM1 NR4A1 OGT ORM1 STAT5A VTN
Entrez ID		1401	2746
HPRD ID		00422	11748
Ensembl ID		ENSG00000132693	ENSG00000148672
Uniprot IDs		P02741	E9KL48 P00367
PDB IDs		1B09 1CRV 1GNH 1LJ7 3L2Y 3PVN 3PVO	1L1F 1NR1 6DQG
Enriched GO Terms of Interacting Partners?
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