CRP and ESS2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		CRP	ESS2
Description		C-reactive protein	ess-2 splicing factor homolog
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Nucleus Catalytic Step 2 Spliceosome
	Molecular Function	Complement Component C1q Complex Binding Calcium Ion Binding Protein Binding Low-density Lipoprotein Particle Binding Choline Binding Identical Protein Binding Virion Binding Low-density Lipoprotein Particle Receptor Binding	Molecular_function Protein Binding
	Biological Process	Acute-phase Response Inflammatory Response Complement Activation, Classical Pathway Opsonization Positive Regulation Of Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Regulation Of Interleukin-8 Production Positive Regulation Of Superoxide Anion Generation Negative Regulation Of Mononuclear Cell Proliferation Vasoconstriction Negative Regulation By Host Of Viral Process Innate Immune Response Defense Response To Gram-positive Bacterium	MRNA Splicing, Via Spliceosome Nervous System Development
Pathways		Classical antibody-mediated complement activation
Drugs		N,N,N-Trimethyl-2-(phosphonooxy)ethanaminium CRx-139
Diseases
GWAS		Blood protein levels ( 30072576 29875488 23696881) C-reactive protein ( 22492993 19567438 21647738 18439548 18439552 21196492 23844046 22939635) C-reactive protein levels ( 33227023 24763700 29403010 33339817 30388399 21300955 28548082) C-reactive protein levels in ischemic stroke ( 26718567) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Erythropoietin levels ( 33227023) High-sensitivity C-reactive protein levels in HIV infection ( 33095540) Inflammatory biomarkers ( 22291609) Inflammatory biomarkers in Kawasaki disease ( 25266886) Lung cancer ( 18385676) Metabolic traits ( 19060910) Protein quantitative trait loci ( 18464913) Select biomarker traits ( 17903293) Serum C-reactive protein concentration ( 32928877) Serum C-reactive protein concentration in obesity ( 32928877) Serum C-reactive protein concentration in visceral obesity (waist circumference) ( 32928877)
Interacting Genes		22 interacting genes: APCS C1QA CFH ESS2 FCGR1A FCGR2A FCGR2B FN1 GLUD1 GMPPA GP6 H1-1 H2AC16 H2AC20 LAMC3 LEP MAPK1 MAPK3 MAPK8IP2 RPL13A SNRNP70 UBE3A	19 interacting genes: ARMC7 CCDC57 CDK5RAP3 CRP DGCR6 DHX16 EXOC8 FRA10AC1 LYST OGT OIP5 PFDN1 QARS1 RACK1 RBM4 SMARCD1 TTC14 VIM WNK2
Entrez ID		1401	8220
HPRD ID		00422	03452
Ensembl ID		ENSG00000132693	ENSG00000100056
Uniprot IDs		P02741	F8WEF8 Q96DF8
PDB IDs		1B09 1CRV 1GNH 1LJ7 3L2Y 3PVN 3PVO
Enriched GO Terms of Interacting Partners?
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