CRP and GMPPA

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		CRP	GMPPA
Description		C-reactive protein	GDP-mannose pyrophosphorylase A
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytoplasm Extracellular Exosome
	Molecular Function	Complement Component C1q Complex Binding Calcium Ion Binding Protein Binding Low-density Lipoprotein Particle Binding Choline Binding Identical Protein Binding Virion Binding Low-density Lipoprotein Particle Receptor Binding	Protein Binding Nucleotidyltransferase Activity
	Biological Process	Acute-phase Response Inflammatory Response Complement Activation, Classical Pathway Opsonization Positive Regulation Of Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Regulation Of Interleukin-8 Production Positive Regulation Of Superoxide Anion Generation Negative Regulation Of Mononuclear Cell Proliferation Vasoconstriction Negative Regulation By Host Of Viral Process Innate Immune Response Defense Response To Gram-positive Bacterium	Biosynthetic Process
Pathways		Classical antibody-mediated complement activation	Synthesis of GDP-mannose
Drugs		N,N,N-Trimethyl-2-(phosphonooxy)ethanaminium CRx-139
Diseases
GWAS		Blood protein levels ( 30072576 29875488 23696881) C-reactive protein ( 22492993 19567438 21647738 18439548 18439552 21196492 23844046 22939635) C-reactive protein levels ( 33227023 24763700 29403010 33339817 30388399 21300955 28548082) C-reactive protein levels in ischemic stroke ( 26718567) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Erythropoietin levels ( 33227023) High-sensitivity C-reactive protein levels in HIV infection ( 33095540) Inflammatory biomarkers ( 22291609) Inflammatory biomarkers in Kawasaki disease ( 25266886) Lung cancer ( 18385676) Metabolic traits ( 19060910) Protein quantitative trait loci ( 18464913) Select biomarker traits ( 17903293) Serum C-reactive protein concentration ( 32928877) Serum C-reactive protein concentration in obesity ( 32928877) Serum C-reactive protein concentration in visceral obesity (waist circumference) ( 32928877)
Interacting Genes		22 interacting genes: APCS C1QA CFH ESS2 FCGR1A FCGR2A FCGR2B FN1 GLUD1 GMPPA GP6 H1-1 H2AC16 H2AC20 LAMC3 LEP MAPK1 MAPK3 MAPK8IP2 RPL13A SNRNP70 UBE3A	10 interacting genes: BTC CDR2 CRP DCUN1D1 GMPPB GPKOW LSM8 NCK1 PNKD ZNF688
Entrez ID		1401	29926
HPRD ID		00422	13588
Ensembl ID		ENSG00000132693	ENSG00000144591
Uniprot IDs		P02741	A0A384MDS7 Q96IJ6
PDB IDs		1B09 1CRV 1GNH 1LJ7 3L2Y 3PVN 3PVO
Enriched GO Terms of Interacting Partners?
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