GLUD1 and NR4A1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		GLUD1	NR4A1
Description		glutamate dehydrogenase 1	nuclear receptor subfamily 4 group A member 1
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Endoplasmic Reticulum	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Mitochondrion Cytosol Nuclear Membrane Presynapse
	Molecular Function	Glutamate Dehydrogenase (NAD+) Activity Glutamate Dehydrogenase [NAD(P)+] Activity Glutamate Dehydrogenase (NADP+) Activity Protein Binding ATP Binding GTP Binding Identical Protein Binding ADP Binding NAD+ Binding Leucine Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Nuclear Receptor Activity Protein Binding Zinc Ion Binding Glucocorticoid Receptor Binding Identical Protein Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Glutamate Biosynthetic Process Glutamate Catabolic Process Glutamine Metabolic Process Substantia Nigra Development Positive Regulation Of Insulin Secretion Tricarboxylic Acid Metabolic Process	Positive Regulation Of Endothelial Cell Proliferation Response To Amphetamine Cell Migration Involved In Sprouting Angiogenesis Regulation Of Transcription By RNA Polymerase II Apoptotic Process Signal Transduction Neurotransmitter Secretion Involved In Regulation Of Skeletal Muscle Contraction Intracellular Receptor Signaling Pathway Response To Lipopolysaccharide Endothelial Cell Chemotaxis Skeletal Muscle Cell Differentiation Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To Fibroblast Growth Factor Stimulus Fat Cell Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Response To Electrical Stimulus Regulation Of Type B Pancreatic Cell Proliferation Cellular Response To Corticotropin-releasing Hormone Stimulus
Pathways		Transcriptional activation of mitochondrial biogenesis Glutamate and glutamine metabolism	AKT phosphorylates targets in the nucleus Nuclear Receptor transcription pathway Constitutive Signaling by AKT1 E17K in Cancer
Drugs		Glutamic acid NADH Hexachlorophene Guanosine-5'-Triphosphate Aluminum chloride
Diseases
GWAS		Renal underexcretion gout ( 32238385)
Interacting Genes		13 interacting genes: ASGR2 CRP CTNNB1 DYNLL1 GOT2 HPX HSD17B10 LSM1 NR4A1 OGT ORM1 STAT5A VTN	88 interacting genes: ABCA5 ABCB11 ABCC13 ABCC6 ABCG8 AKT1 ANKIB1 ARHGEF10L ARHGEF5 ATM ATXN1 BBS10 BCL2 BCL2A1 BCL2L10 CD2AP CDKN2D CHD1L CHD3 CHEK2 CPT1A CUTA DIABLO EP300 ERBB3 FAF1 FXYD3 GADD45GIP1 GK GLOD4 GLUD1 HADHA HES1 HIF1A HNRNPA2B1 HSP90AB1 KAT2B KRTAP10-1 KRTAP10-5 LONRF1 LSS MAP3K1 MAPK1 MAPK8 MED1 MED31 NACAD NCOA1 NCOA2 NCOA3 NCOR2 NDRG1 NFKB1 NR3C1 PGBD1 PML POLA2 PPARG PPBP PPM1A PRDX4 PRDX6 RBL1 ROBO2 RPL7 RPS6KA1 RPS6KA3 RPS6KA5 RPS6KA6 RTN4 RXRA RXRG SERPINA4 SERPING1 SMAD3 SOCS4 STAT3 SUGT1 TCF4 TP53 TRAF2 TRIM28 TUBB4A VASP VHL YWHAZ ZNF331 ZNF579
Entrez ID		2746	3164
HPRD ID		11748	00744
Ensembl ID		ENSG00000148672	ENSG00000123358
Uniprot IDs		E9KL48 P00367	A0A024R126 F5GXF0 P22736 Q6ZMM6
PDB IDs		1L1F 1NR1 6DQG	2QW4 3V3E 3V3Q 4JGV 4KZI 4KZJ 4KZM 4RE8 4REE 4REF 4RZE 4RZF 4RZG 4WHF 4WHG 6KZ5 6LC1
Enriched GO Terms of Interacting Partners?
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