SOCS4 and SPRY1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		SOCS4	SPRY1
Description		suppressor of cytokine signaling 4	sprouty RTK signaling antagonist 1
Image			No pdb structure
GO Annotations	Cellular Component	Phosphatidylinositol 3-kinase Complex	Nucleoplasm Golgi Apparatus Cytosol Plasma Membrane
	Molecular Function	Protein Binding 1-phosphatidylinositol-3-kinase Regulator Activity	Protein Binding
	Biological Process	Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Regulation Of Growth Regulation Of Phosphatidylinositol 3-kinase Activity Phosphatidylinositol Phosphate Biosynthetic Process	Establishment Of Mitotic Spindle Orientation Metanephros Development Ureteric Bud Development Organ Induction Negative Regulation Of Cell Population Proliferation Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of GTPase Activity Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of MAP Kinase Activity Negative Regulation Of Ras Protein Signal Transduction Animal Organ Development Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Bud Elongation Involved In Lung Branching Epithelial To Mesenchymal Transition Involved In Cardiac Fibroblast Development Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Lens Fiber Cell Differentiation
Pathways		RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	EGFR downregulation
Drugs
Diseases
GWAS		Low density lipoprotein cholesterol levels ( 33339817) Total cholesterol levels ( 33339817)	Apolipoprotein B levels ( 32203549) Body shape index ( 34021172) Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Irritable bowel syndrome ( 24797007) Itch intensity from mosquito bite adjusted by bite size ( 28199695) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Metabolite levels ( 23823483) Pelvic organ prolapse ( 26545240) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Triglyceride levels ( 32203549)
Interacting Genes		11 interacting genes: CNMD EGFR LDHAL6B MDFIC NR4A1 PALS1 PLPP6 SPRY1 TEKT4 TNK2 VWF	85 interacting genes: ADAM12 ADAMTSL4 ANKRD11 ATXN7 CACNA1A CCDC57 CDR2L CHRD CREB5 CYSRT1 FARS2 FBLN1 FHL5 FXR1 FXR2 GEMIN4 GNE GRB2 GUCD1 HEXIM2 HOXA1 HRG HSF2BP INCA1 KPNA2 KPRP KRT31 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-2 KRTAP12-3 KRTAP3-2 KRTAP4-12 KRTAP4-2 KRTAP5-9 KRTAP9-2 KRTAP9-3 LCE1A LCE1B LCE1C LCE1D LCE1F LCE2A LCE2C LCE2D LCE3A LCE3C LCE3D LCE4A LCE5A MB21D2 MDFI MEOX2 NBPF19 NOTCH2NLA NTM OTX1 PCSK5 POLR1C PRKAA2 PRKAB2 R3HDM2 REL SMCP SOCS4 SPRY2 STAT3 TFAP2D TGM7 UBASH3A VWC2 YY1 ZNF23 ZNF330 ZNF417 ZNF441 ZNF837
Entrez ID		122809	10252
HPRD ID		18084	06782
Ensembl ID		ENSG00000180008	ENSG00000164056
Uniprot IDs		Q5H9R6 Q8WXH5	O43609
PDB IDs		2IZV
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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