FRS3 and NUMB

Number of citations of the paper that reports this interaction (PubMedID 25814554)
26

Data Source:
BioGRID (two hybrid)

		FRS3	NUMB
Description		fibroblast growth factor receptor substrate 3	NUMB endocytic adaptor protein
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane	Nucleus Cytoplasm Early Endosome Plasma Membrane Clathrin-coated Pit Focal Adhesion Endosome Membrane Basolateral Plasma Membrane Extrinsic Component Of Plasma Membrane Clathrin-coated Vesicle Apical Part Of Cell Glutamatergic Synapse
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Fibroblast Growth Factor Receptor Binding Protein Binding Identical Protein Binding	Protein Binding Beta-catenin Binding Alpha-catenin Binding Cadherin Binding
	Biological Process	Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway	Axonogenesis Lateral Ventricle Development Neuroblast Division In Subventricular Zone Positive Regulation Of Cell Migration Adherens Junction Organization Positive Regulation Of Neurogenesis Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		FRS-mediated FGFR1 signaling FRS-mediated FGFR2 signaling FRS-mediated FGFR3 signaling FRS-mediated FGFR4 signaling RAF/MAP kinase cascade Activated NTRK2 signals through FRS2 and FRS3 RND2 GTPase cycle RND1 GTPase cycle Signaling by ALK fusions and activated point mutants	Activated NOTCH1 Transmits Signal to the Nucleus Recycling pathway of L1 Degradation of GLI1 by the proteasome Hedgehog 'on' state
Drugs
Diseases
GWAS		Menarche (age at onset) ( 25231870)	Bipolar disorder with mood-incongruent psychosis ( 23092984) Coronary artery calcification ( 17903303) Hemoglobin ( 32888494) Macular thickness ( 30535121) Multisite chronic pain ( 33830993 31194737) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
Interacting Genes		112 interacting genes: ADAMTSL4 ANAPC11 ANKRD55 ATP23 BLZF1 BMPR2 C11orf1 C11orf45 C19orf54 C22orf39 CATSPER1 CBY2 CCDC33 CCN3 CDPF1 COL8A1 COPS3 CREB5 CYSRT1 DCDC2B DDX5 DMRT3 DPEP2NB ECM1 ESM1 FGFR1 GATA1 GPRIN2 GRB14 GRB2 HOXA1 HOXD12 ID2 ID3 IKZF3 INCA1 ISY1-RAB43 KARS1 KATNBL1 KIAA0408 KPRP KRT31 KRT33B KRT34 KRT35 KRT76 KRTAP1-1 KRTAP10-8 KRTAP11-1 KRTAP3-1 KRTAP3-2 KRTAP6-2 LINGO1 LRRC18 MAPK1 MATK MBD3L1 MIIP NADSYN1 NBPF19 NOTCH2NLA NTRK1 NTRK2 NUMB PCSK5 PDLIM7 PIH1D2 PLB1 PLLP PLSCR1 POF1B PPP1R32 PRDM6 PRKCI PTPN11 RFX6 RIMBP3C RND1 SCNM1 SH2B1 SHANK3 SLAIN1 SLC22A18AS SOCS6 SPATA12 SPRY2 STH STK16 TCF4 TCP10L TGM7 TLE5 TNS1 TRAF4 TRIP6 TSC1 TSGA10IP TSPAN4 UNKL VASP VGLL3 WDR83 WWOX YPEL3 ZMIZ2 ZNF124 ZNF417 ZNF438 ZNF446 ZNF552 ZNF69 ZSCAN30	36 interacting genes: AP2A1 AP2A2 APP DPYSL2 EAF1 EGFR EPS15 FBXO7 FRS3 IRS1 ITCH ITGB2 ITGB3 ITGB5 L1CAM LNX1 LNX2 MAPK8IP2 MDM2 NEDD4 NOTCH1 OLIG1 PALS1 PDZK1IP1 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCZ PTEN RPL3 SIAH1 SPANXN2 TERF2
Entrez ID		10817	8650
HPRD ID		06373	04767
Ensembl ID		ENSG00000137218	ENSG00000133961
Uniprot IDs		A0A140VJJ7 O43559	A0A024R681 A0A024R684 A0A024R6C4 A0A024R6F4 P49757
PDB IDs		2KUP 2KUQ 2YS5 2YT2	5NJJ 5NJK
Enriched GO Terms of Interacting Partners?
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