FRS3 and HOXD12

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		FRS3	HOXD12
Description		fibroblast growth factor receptor substrate 3	homeobox D12
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Fibroblast Growth Factor Receptor Binding Protein Binding Identical Protein Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway	Skeletal System Development Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Embryonic Digit Morphogenesis
Pathways		FRS-mediated FGFR1 signaling FRS-mediated FGFR2 signaling FRS-mediated FGFR3 signaling FRS-mediated FGFR4 signaling RAF/MAP kinase cascade Activated NTRK2 signals through FRS2 and FRS3 RND2 GTPase cycle RND1 GTPase cycle Signaling by ALK fusions and activated point mutants
Drugs
Diseases
GWAS		Menarche (age at onset) ( 25231870)	Digit length ratio ( 29659830) Digit length ratio (left hand) ( 29659830) Digit length ratio (right hand) ( 29659830) Male-pattern baldness ( 28196072)
Interacting Genes		112 interacting genes: ADAMTSL4 ANAPC11 ANKRD55 ATP23 BLZF1 BMPR2 C11orf1 C11orf45 C19orf54 C22orf39 CATSPER1 CBY2 CCDC33 CCN3 CDPF1 COL8A1 COPS3 CREB5 CYSRT1 DCDC2B DDX5 DMRT3 DPEP2NB ECM1 ESM1 FGFR1 GATA1 GPRIN2 GRB14 GRB2 HOXA1 HOXD12 ID2 ID3 IKZF3 INCA1 ISY1-RAB43 KARS1 KATNBL1 KIAA0408 KPRP KRT31 KRT33B KRT34 KRT35 KRT76 KRTAP1-1 KRTAP10-8 KRTAP11-1 KRTAP3-1 KRTAP3-2 KRTAP6-2 LINGO1 LRRC18 MAPK1 MATK MBD3L1 MIIP NADSYN1 NBPF19 NOTCH2NLA NTRK1 NTRK2 NUMB PCSK5 PDLIM7 PIH1D2 PLB1 PLLP PLSCR1 POF1B PPP1R32 PRDM6 PRKCI PTPN11 RFX6 RIMBP3C RND1 SCNM1 SH2B1 SHANK3 SLAIN1 SLC22A18AS SOCS6 SPATA12 SPRY2 STH STK16 TCF4 TCP10L TGM7 TLE5 TNS1 TRAF4 TRIP6 TSC1 TSGA10IP TSPAN4 UNKL VASP VGLL3 WDR83 WWOX YPEL3 ZMIZ2 ZNF124 ZNF417 ZNF438 ZNF446 ZNF552 ZNF69 ZSCAN30	17 interacting genes: ACTN3 CABP2 CREBBP DTX2 FGF14 FRS3 MAF MAFB MAFF MAFG MAFK MEIS1 MKRN3 POLR1C TFAP2D TRAF1 TTC19
Entrez ID		10817	3238
HPRD ID		06373	00871
Ensembl ID		ENSG00000137218	ENSG00000170178
Uniprot IDs		A0A140VJJ7 O43559	P35452
PDB IDs		2KUP 2KUQ 2YS5 2YT2
Enriched GO Terms of Interacting Partners?
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