FRS3 and SH2B1

Number of citations of the paper that reports this interaction (PubMedID 25814554)
26

Data Source:
BioGRID (two hybrid)

		FRS3	SH2B1
Description		fibroblast growth factor receptor substrate 3	SH2B adaptor protein 1
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane	Nucleus Cytosol Plasma Membrane
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Fibroblast Growth Factor Receptor Binding Protein Binding Identical Protein Binding	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding
	Biological Process	Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Intracellular Signal Transduction Positive Regulation Of SMAD Protein Signal Transduction
Pathways		FRS-mediated FGFR1 signaling FRS-mediated FGFR2 signaling FRS-mediated FGFR3 signaling FRS-mediated FGFR4 signaling RAF/MAP kinase cascade Activated NTRK2 signals through FRS2 and FRS3 RND2 GTPase cycle RND1 GTPase cycle Signaling by ALK fusions and activated point mutants	Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Menarche (age at onset) ( 25231870)	Adult body size ( 32376654) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body fat percentage ( 26833246) Body mass index ( 29381148 19079260 19079261 20935630 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Cognitive ability ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Crohn's disease ( 28067908 21102463) Dental caries (decayed, missing and filled teeth) ( 31533690) Educational attainment ( 25201988) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431) Inflammatory bowel disease ( 28067908) Intelligence ( 28530673) Lamb consumption ( 32066663) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Obesity ( 23563607) QT interval ( 29213071) Red blood cell count ( 32888494 27863252) Waist circumference ( 25673412) Weight ( 19079260)
Interacting Genes		112 interacting genes: ADAMTSL4 ANAPC11 ANKRD55 ATP23 BLZF1 BMPR2 C11orf1 C11orf45 C19orf54 C22orf39 CATSPER1 CBY2 CCDC33 CCN3 CDPF1 COL8A1 COPS3 CREB5 CYSRT1 DCDC2B DDX5 DMRT3 DPEP2NB ECM1 ESM1 FGFR1 GATA1 GPRIN2 GRB14 GRB2 HOXA1 HOXD12 ID2 ID3 IKZF3 INCA1 ISY1-RAB43 KARS1 KATNBL1 KIAA0408 KPRP KRT31 KRT33B KRT34 KRT35 KRT76 KRTAP1-1 KRTAP10-8 KRTAP11-1 KRTAP3-1 KRTAP3-2 KRTAP6-2 LINGO1 LRRC18 MAPK1 MATK MBD3L1 MIIP NADSYN1 NBPF19 NOTCH2NLA NTRK1 NTRK2 NUMB PCSK5 PDLIM7 PIH1D2 PLB1 PLLP PLSCR1 POF1B PPP1R32 PRDM6 PRKCI PTPN11 RFX6 RIMBP3C RND1 SCNM1 SH2B1 SHANK3 SLAIN1 SLC22A18AS SOCS6 SPATA12 SPRY2 STH STK16 TCF4 TCP10L TGM7 TLE5 TNS1 TRAF4 TRIP6 TSC1 TSGA10IP TSPAN4 UNKL VASP VGLL3 WDR83 WWOX YPEL3 ZMIZ2 ZNF124 ZNF417 ZNF438 ZNF446 ZNF552 ZNF69 ZSCAN30	17 interacting genes: CSAD EGFR ERBB2 ERBB3 ERBB4 FGFR3 FRS3 GRB2 IGF1R INSR JAK2 KIAA0319 MET NTRK1 NTRK2 RHBG SH2B2
Entrez ID		10817	25970
HPRD ID		06373	12336
Ensembl ID		ENSG00000137218	ENSG00000178188
Uniprot IDs		A0A140VJJ7 O43559	A0A024QZ92 A0A024QZC2 A0A024QZD2 B3KNV5 B4DLN5 Q9NRF2
PDB IDs		2KUP 2KUQ 2YS5 2YT2	5W3R
Enriched GO Terms of Interacting Partners?
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