FRS3 and KRTAP10-8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		FRS3	KRTAP10-8
Description		fibroblast growth factor receptor substrate 3	keratin associated protein 10-8
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane	Cytosol Keratin Filament
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Fibroblast Growth Factor Receptor Binding Protein Binding Identical Protein Binding	Protein Binding Identical Protein Binding
	Biological Process	Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway
Pathways		FRS-mediated FGFR1 signaling FRS-mediated FGFR2 signaling FRS-mediated FGFR3 signaling FRS-mediated FGFR4 signaling RAF/MAP kinase cascade Activated NTRK2 signals through FRS2 and FRS3 RND2 GTPase cycle RND1 GTPase cycle Signaling by ALK fusions and activated point mutants	Keratinization
Drugs
Diseases
GWAS		Menarche (age at onset) ( 25231870)
Interacting Genes		112 interacting genes: ADAMTSL4 ANAPC11 ANKRD55 ATP23 BLZF1 BMPR2 C11orf1 C11orf45 C19orf54 C22orf39 CATSPER1 CBY2 CCDC33 CCN3 CDPF1 COL8A1 COPS3 CREB5 CYSRT1 DCDC2B DDX5 DMRT3 DPEP2NB ECM1 ESM1 FGFR1 GATA1 GPRIN2 GRB14 GRB2 HOXA1 HOXD12 ID2 ID3 IKZF3 INCA1 ISY1-RAB43 KARS1 KATNBL1 KIAA0408 KPRP KRT31 KRT33B KRT34 KRT35 KRT76 KRTAP1-1 KRTAP10-8 KRTAP11-1 KRTAP3-1 KRTAP3-2 KRTAP6-2 LINGO1 LRRC18 MAPK1 MATK MBD3L1 MIIP NADSYN1 NBPF19 NOTCH2NLA NTRK1 NTRK2 NUMB PCSK5 PDLIM7 PIH1D2 PLB1 PLLP PLSCR1 POF1B PPP1R32 PRDM6 PRKCI PTPN11 RFX6 RIMBP3C RND1 SCNM1 SH2B1 SHANK3 SLAIN1 SLC22A18AS SOCS6 SPATA12 SPRY2 STH STK16 TCF4 TCP10L TGM7 TLE5 TNS1 TRAF4 TRIP6 TSC1 TSGA10IP TSPAN4 UNKL VASP VGLL3 WDR83 WWOX YPEL3 ZMIZ2 ZNF124 ZNF417 ZNF438 ZNF446 ZNF552 ZNF69 ZSCAN30	388 interacting genes: - ACY3 ADAM12 ADAMTS1 ADAMTSL3 ADAMTSL4 AEBP2 AEN AK3 ALDH3B1 ALPI ALPP AMMECR1 ANKS1A AP1M1 APOL6 AQP1 AREG ARID5A ASPSCR1 ATG9A ATP5F1D AVPI1 AXIN2 BAHD1 BCL6B BEX2 BMP7 BRME1 C10orf62 C11orf87 C17orf50 C19orf25 C22orf39 C2orf68 C3 CAMK1G CARD10 CARHSP1 CATSPER1 CCDC26 CCNJL CHIC2 CHRD CHRNG CLK4 CNNM3 COL8A1 COX17 CRCT1 CREB5 CRH CRY2 CSF1 CTRC CYP2S1 CYSRT1 DAAM2 DCX DDX43 DDX55 DDX6 DERL2 DHRS1 DHX57 DMRT3 DOCK2 ECE1 EFEMP2 EIF4E2 ENKD1 EPDR1 FADS6 FAH FAM110A FAM161A FAM221B FAM27E3 FAM71C FAM74A4 FAM76B FAM90A1 FARS2 FBXO34 FBXW5 FEZF1 FOXB1 FRS3 FTHL17 FZD10 GEM GFOD1 GLIDR GLP1R GLRX3 GLYAT GNAI2 GNE GOLGA8EP GPANK1 GPHB5 GPRIN2 GRN GUCD1 HAPLN2 HCK HHEX HOXA1 HOXB5 HOXB9 HOXC8 HPCAL1 HS6ST1 HSD3B7 HSPA12B HSPD1 ICAM1 IGFBP6 IGSF8 IL10 IL16 IL2RG INO80B INTS5 IP6K3 ITGB2 ITGB4 ITGB5 JOSD1 JPH3 KLHL38 KLK8 KPRP KRT20 KRT83 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP15-1 KRTAP17-1 KRTAP19-7 KRTAP3-1 KRTAP3-2 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP4-7 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LAGE3 LASP1 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LELP1 LENG1 LINC00656 LMF2 LNX1 LRCH4 LRFN4 LUZP4 LYVE1 MACROH2A1 MAPKBP1 MATN3 MEIS2 MELTF MEOX2 MLLT6 MOBP MTA1 MUL1 MXI1 MYPOP NAB2 NAXD NBPF19 NECTIN2 NECTIN3 NEK6 NKD1 NOTCH2NLA NPDC1 NR1D2 NR4A3 NTN4 NUFIP2 OLIG3 OPCML OTX1 P2RX7 P2RY6 PAX5 PCED1A PCSK5 PDE9A PDIA4 PGAP6 PGLS PHLDA1 PIGS PIN1 PKD2 PLSCR4 POM121L8P POU1F1 POU4F2 PRKAB2 PRPF31 PRR13 PRR19 PTGER3 PTK7 PTPMT1 PTPRH PVR QPRT R3HDM2 RAB19 RAB3A RALGDS RANBP3 RASD1 RECK RGL2 RHBDL1 RHNO1 RNF38 RNF8 RPS19BP1 RPS28 RTN4RL1 SCARF1 SCNM1 SEMA3B SH3GLB2 SHFL SLC13A5 SLC22A23 SLC23A1 SLC25A10 SLC25A31 SLC25A42 SLC6A20 SLIT1 SMARCE1 SMCP SMG9 SMOC1 SPACA9 SPAG8 SPATA24 SPATA3 SPRY1 SPRY2 SSC4D STK16 SUSD2 SUSD6 SUV39H1 TACSTD2 TAPBPL TBC1D16 TBC1D23 TCAF1 TCEA2 TCEANC TFAP2D TGFB1 THAP10 THAP7 TIE1 TLE5 TMEM140 TMEM150A TMIE TNIP3 TNP2 TNPO3 TNS2 TRIM41 TRIM42 TRPV6 TSPAN4 TTC23 TXNDC5 TYMSOS TYRO3 UBL5 UTP23 UXT VASN VENTX VEZF1 VGLL3 VPS11 VWC2 VWC2L WIF1 WNT11 WT1 WT1-AS YIPF3 YY1 ZBTB24 ZBTB25 ZDHHC1 ZFYVE21 ZIC1 ZNF101 ZNF107 ZNF121 ZNF124 ZNF138 ZNF165 ZNF20 ZNF23 ZNF250 ZNF264 ZNF266 ZNF319 ZNF32 ZNF330 ZNF408 ZNF414 ZNF417 ZNF439 ZNF440 ZNF444 ZNF473 ZNF490 ZNF491 ZNF497 ZNF524 ZNF559 ZNF572 ZNF575 ZNF578 ZNF580 ZNF581 ZNF587 ZNF625 ZNF648 ZNF669 ZNF696 ZNF697 ZNF775 ZNF786 ZNF79 ZNF792 ZNF837 ZSCAN12 ZSCAN21
Entrez ID		10817	386681
HPRD ID		06373	11194
Ensembl ID		ENSG00000137218	ENSG00000187766
Uniprot IDs		A0A140VJJ7 O43559	P60410
PDB IDs		2KUP 2KUQ 2YS5 2YT2
Enriched GO Terms of Interacting Partners?
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