CCL26 and CCR3

Number of citations of the paper that reports this interaction (PubMedID 10488147)
37

Data Source:
HPRD (in vivo)

		CCL26	CCR3
Description		C-C motif chemokine ligand 26	C-C motif chemokine receptor 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Protein Binding Chemokine Activity CCR3 Chemokine Receptor Binding CX3C Chemokine Receptor Binding Receptor Ligand Activity CCR Chemokine Receptor Binding	Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Monocyte Chemotaxis Chemotaxis Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling T Cell Chemotaxis Positive Regulation Of Cell Migration Neutrophil Chemotaxis Positive Regulation Of Actin Filament Polymerization Positive Regulation Of GTPase Activity Eosinophil Chemotaxis Lymphocyte Chemotaxis Positive Regulation Of Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor	Positive Regulation Of Endothelial Cell Proliferation Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Cell Adhesion Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Positive Regulation Of Angiogenesis Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways			Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases
GWAS		Carotid plaque burden ( 28282560) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309)	Arthritis (juvenile idiopathic) ( 33106285) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Behcet's disease ( 33393726 23291587) Blood protein levels ( 28240269) Bone mineral density (Ward's triangle area) ( 27397699) Celiac disease ( 22057235 20190752 25920553 24999842 18311140) Celiac disease and Rheumatoid arthritis ( 26546613) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 26192919) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Monocyte chemoattractant protein-1 levels ( 23017229) Monocyte count ( 29403010 27863252) Narcolepsy with cataplexy ( 25986216) Obesity-related traits ( 23251661) Pancreatic beta-cell glucose sensitivity ( 32944759) Ulcerative colitis ( 26192919 28067908) White blood cell count (basophil) ( 27863252)
Interacting Genes		24 interacting genes: APP C3orf52 CCL11 CCL13 CCL17 CCL2 CCL21 CCL28 CCL5 CCL8 CCR1 CCR3 CXCL10 CXCL11 CXCL12 CXCL14 CXCL17 CXCL9 PAX6 PF4 PF4V1 PPBP XCL1 XCL2	19 interacting genes: CCL11 CCL13 CCL14 CCL15 CCL2 CCL24 CCL26 CCL28 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCL8 CXCL10 CXCL11 CXCL9 FGR HCK
Entrez ID		10344	1232
HPRD ID		05262	03167
Ensembl ID		ENSG00000006606	ENSG00000183625
Uniprot IDs		Q9Y258	A1LPE5 P51677 Q8TDP4 Q8TDP5
PDB IDs		1G2S 1G2T
Enriched GO Terms of Interacting Partners?
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