RNF41 and ORMDL2

		RNF41	ORMDL2
Description		ring finger protein 41	ORMDL sphingolipid biosynthesis regulator 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Tubular Network	Endoplasmic Reticulum Integral Component Of Membrane SPOTS Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein Domain Specific Binding Receptor Tyrosine Kinase Binding Small GTPase Binding Identical Protein Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Protein Polyubiquitination Autophagy Negative Regulation Of Cell Population Proliferation Proteasomal Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Cell Migration Regulation Of MAPK Cascade Positive Regulation Of Protein Catabolic Process Protein Autoubiquitination Regulation Of Protein Kinase B Signaling Extrinsic Apoptotic Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process	Ceramide Metabolic Process Cellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process
Pathways		Downregulation of ERBB2:ERBB3 signaling Antigen processing: Ubiquitination & Proteasome degradation	Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Asthma ( 31619474) Height ( 34054925)	Refractive error ( 32231278)
Interacting Genes		49 interacting genes: ADRB2 AP2S1 APP ARL6IP4 ASB6 BIRC6 C1orf109 CLEC9A ENOPH1 ERBB3 ERBB4 GDF11 IRS4 ISCA2 KDM3B LEPR LZTS2 MAGEL2 MARK2 MEOX2 MNAT1 MTNR1A MTNR1B MTURN N4BP3 NEUROD4 ORMDL2 PPP1R1A RAD23A RFC4 RNF166 RRM2B SRR SUOX TBATA TCEANC TRIM32 TRIM8 TSG101 TTC1 UBASH3A UBASH3B UBE2D3 UBE2K UBE2U UBE2Z USP8 VPS52 ZAP70	22 interacting genes: AQP6 CD79A CREB3L1 CYB561 CYB5R3 DAPK1 EBP ELOVL4 FAM210B FCER1G GJA8 KCNJ6 MMGT1 RETREG3 RNF41 SCN3B SLC10A1 TMEM120A TMEM31 TMEM86B TMX2 ZDHHC15
Entrez ID		10193	29095
HPRD ID		11520	17802
Ensembl ID		ENSG00000181852	ENSG00000123353
Uniprot IDs		A0A024RB33 Q9H4P4	Q53FV1
PDB IDs		2FZP 2GWF
Enriched GO Terms of Interacting Partners?
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