RNF41 and MTNR1B

Number of citations of the paper that reports this interaction (PubMedID 26514267)
11

Data Source:
BioGRID (two hybrid)

		RNF41	MTNR1B
Description		ring finger protein 41	melatonin receptor 1B
Image
GO Annotations	Cellular Component	Cytosol Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Tubular Network	Plasma Membrane Integral Component Of Plasma Membrane Synapse
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein Domain Specific Binding Receptor Tyrosine Kinase Binding Small GTPase Binding Identical Protein Binding Ubiquitin Protein Ligase Activity	G Protein-coupled Receptor Activity Protein Binding Melatonin Receptor Activity
	Biological Process	Protein Polyubiquitination Autophagy Negative Regulation Of Cell Population Proliferation Proteasomal Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Cell Migration Regulation Of MAPK Cascade Positive Regulation Of Protein Catabolic Process Protein Autoubiquitination Regulation Of Protein Kinase B Signaling Extrinsic Apoptotic Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Chemical Synaptic Transmission Negative Regulation Of CGMP-mediated Signaling Glucose Homeostasis Camera-type Eye Development Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Vasoconstriction Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Insulin Secretion Regulation Of Insulin Secretion Negative Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Transmission Of Nerve Impulse Regulation Of Neuronal Action Potential Negative Regulation Of Delayed Rectifier Potassium Channel Activity
Pathways		Downregulation of ERBB2:ERBB3 signaling Antigen processing: Ubiquitination & Proteasome degradation	Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events
Drugs			Ramelteon Melatonin Resveratrol Agomelatine Tasimelteon
Diseases
GWAS		Asthma ( 31619474) Height ( 34054925)	Acute insulin response ( 28490609) Adverse response to radiation therapy ( 23719583) Birth weight ( 31043758 27680694) Chronotype ( 30696823) Corrected insulin response ( 24699409) Corrected insulin response adjusted for insulin sensitivity index ( 24699409) Daytime nap ( 33568662) Dental caries (decayed and filled deciduous teeth) ( 31533690) Dental caries (decayed and filled deciduous tooth surfaces) ( 31533690) Depressive symptoms x dependent stressful life events interaction (1df test) ( 30718454) Depressive symptoms x dependent stressful life events interaction (2df test) ( 30718454) Diabetes (gestational) ( 22233651) Fasting blood glucose ( 29844224 33842983 25631608 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting glucose ( 33402679 34059833) Fasting plasma glucose ( 25187374 19060907 19060909 19651812 22508271) Glucose homeostasis traits ( 25524916) Glycated hemoglobin levels ( 34059833 20858683 28898252) Glycemic traits ( 23575436) Glycemic traits (pleiotropy) ( 31021400) Glycemic traits (pregnancy) ( 23903356) Hemoglobin A1c levels ( 29403010) High fasting blood glucose ( 31910446) Homeostasis model assessment of beta-cell function ( 20081858) Incremental insulin ( 24699409) Insomnia (caffeine-induced) ( 22754043) Insulin disposition index ( 24699409 28490609) Insulin levels ( 24699409) Insulin levels adjusted for BMI ( 24699409) Insulin secretion rate ( 28490609) Insulin-related traits (multivariate analysis) ( 32002517) Metabolic syndrome ( 22399527) Metabolic traits ( 19060910) Metabolite levels ( 21909109 22286219) Metabolite levels (small molecules and protein measures) ( 27005778) Obesity-related traits ( 23251661) Offspring birth weight ( 31043758 29309628) Peak insulin response ( 28490609) Pulse pressure ( 30224653 30578418) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Type 2 diabetes ( 22885922 24509480 30054458 29358691 30297969 28254843 32499647 20581827 28869590) Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia ( 25710658)
Interacting Genes		49 interacting genes: ADRB2 AP2S1 APP ARL6IP4 ASB6 BIRC6 C1orf109 CLEC9A ENOPH1 ERBB3 ERBB4 GDF11 IRS4 ISCA2 KDM3B LEPR LZTS2 MAGEL2 MARK2 MEOX2 MNAT1 MTNR1A MTNR1B MTURN N4BP3 NEUROD4 ORMDL2 PPP1R1A RAD23A RFC4 RNF166 RRM2B SRR SUOX TBATA TCEANC TRIM32 TRIM8 TSG101 TTC1 UBASH3A UBASH3B UBE2D3 UBE2K UBE2U UBE2Z USP8 VPS52 ZAP70	133 interacting genes: ACKR1 ACTN1 ADCY3 ANXA6 AP1B1 AP4E1 APOL6 ARHGAP1 ARHGAP28 ATP6V0B BCL2L1 BCL2L13 BTBD1 CANX CD99 CDC16 CDH11 CDH13 CDH4 CLASP1 CLDND1 COG4 COG8 COPA COX11 CRELD1 CSE1L CTNNA1 CTNND1 CUL3 DISP3 DMXL2 DST DYNC1H1 DYNC2H1 EBF1 EBP EIF3A ERG28 ESPL1 EVA1A FANCI FLNA FSTL1 FTL GGT7 GNAI1 GNAI2 GNAI3 GNAS GNB1 GNB2 GNB4 GPM6B GPR50 HARS1 HECTD1 HNRNPA0 HSPA5 INTS1 IPO4 IPO9 IRF2BP2 IRS4 ITM2C ITPR3 KMT2C LTBR MACF1 MARCHF6 MARF1 MFF MIA3 MMP2 MON2 MTMR6 MTNR1A OTX1 PCDHB10 PCNX4 PDIA3 PDIA6 PEAK1 PI4KA PIDD1 POLI PPM1G PPP1R21 PPP6R1 PRKDC PSMD8 PSME3IP1 PTPRD RECK RIPOR2 RNF185 RNF40 RNF41 RPRD2 SDHD SF3A3 SLC12A4 SLC2A3 SLC30A1 SLC39A6 SLC3A2 SLC4A7 SMARCD1 SMC3 SREBF1 SREBF2 STMN4 SYNE2 TANGO6 TBCD THOC1 THRA TINF2 TLN1 TMEM14A TMEM230 TRIM24 TRIM46 TRIP12 UBAP2L UBQLN2 UBQLN4 UBR4 USP34 VPS35 XBP1 YWHAB YWHAQ
Entrez ID		10193	4544
HPRD ID		11520	02882
Ensembl ID		ENSG00000181852	ENSG00000134640
Uniprot IDs		A0A024RB33 Q9H4P4	P49286
PDB IDs		2FZP 2GWF	6ME6 6ME7 6ME8 6ME9
Enriched GO Terms of Interacting Partners?
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