ORMDL2 and CYB561

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ORMDL2	CYB561
Description		ORMDL sphingolipid biosynthesis regulator 2	cytochrome b561
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Integral Component Of Membrane SPOTS Complex	Lysosomal Membrane Integral Component Of Membrane Chromaffin Granule Membrane
	Molecular Function	Protein Binding	Protein Binding Oxidoreductase Activity Metal Ion Binding Transmembrane Monodehydroascorbate Reductase Activity
	Biological Process	Ceramide Metabolic Process Cellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process	Cellular Iron Ion Homeostasis Electron Transport Chain Ascorbate Homeostasis
Pathways		Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Refractive error ( 32231278)	Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Diastolic blood pressure ( 28739976)
Interacting Genes		22 interacting genes: AQP6 CD79A CREB3L1 CYB561 CYB5R3 DAPK1 EBP ELOVL4 FAM210B FCER1G GJA8 KCNJ6 MMGT1 RETREG3 RNF41 SCN3B SLC10A1 TMEM120A TMEM31 TMEM86B TMX2 ZDHHC15	60 interacting genes: ANKRD46 AQP6 BEST2 BET1 BIK BNIP1 CD79A CDIPT CLDN9 CMTM2 CREB3 DARS2 EBP EDA EFNA5 EHHADH ERG28 ERGIC3 FKBP8 GGT7 GIMAP5 GOSR2 GPR152 GPX8 HMOX1 LHFPL5 LMNA LPAR3 NCOA1 OPRM1 ORMDL2 PLP2 REEP6 RNF5 SCD SEC22A SERP2 SLC19A3 SLC35C2 SLC38A7 SLC39A1 SLC39A2 SMIM1 SSMEM1 STX3 SYNJ2BP TM4SF18 TMEM11 TMEM128 TMEM14B TMEM179B TMEM242 TMEM65 TMPPE TREX1 TSNARE1 UBE2J1 VAPA VAPB ZDHHC7
Entrez ID		29095	1534
HPRD ID		17802	02485
Ensembl ID		ENSG00000123353	ENSG00000008283
Uniprot IDs		Q53FV1	B3KTA1 J3QRH5 P49447
PDB IDs
Enriched GO Terms of Interacting Partners?
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