TOM1 and MYO6

Number of citations of the paper that reports this interaction (PubMedID 23023224)
119

Data Source:
BioGRID (proximity labelling technology, affinity chromatography technology, two hybrid)

		TOM1	MYO6
Description		target of myb1 membrane trafficking protein	myosin VI
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GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Membrane Azurophil Granule Membrane Specific Granule Membrane Extracellular Exosome	Ruffle Nucleus Nucleoplasm Cytoplasm Lysosomal Membrane Golgi Apparatus Cytosol Actin Filament Plasma Membrane Microvillus Clathrin-coated Pit Cell Cortex Actin Cytoskeleton Membrane Unconventional Myosin Complex RNA Polymerase II, Holoenzyme Endocytic Vesicle Filopodium Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Filamentous Actin Nuclear Membrane Vesicle Ruffle Membrane Apical Part Of Cell Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding Clathrin Binding Phosphatidylinositol Binding Ubiquitin Binding	Microfilament Motor Activity Cytoskeletal Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding ADP Binding Actin Filament Binding Minus-end Directed Microfilament Motor Activity
	Biological Process	Endocytosis Signal Transduction Protein Transport Endosomal Transport	Intracellular Protein Transport Endocytosis Actin Filament Organization Sensory Perception Of Sound Response To Xenobiotic Stimulus Actin Filament-based Movement Vesicle Transport Along Actin Filament DNA Damage Response, Signal Transduction By P53 Class Mediator Inner Ear Morphogenesis Inner Ear Auditory Receptor Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Secretion
Pathways		Neutrophil degranulation	Gap junction degradation Trafficking of AMPA receptors RHOBTB2 GTPase cycle RHOU GTPase cycle RHOBTB1 GTPase cycle
Drugs
Diseases
GWAS		Cholesterol, total ( 24097068) HDL cholesterol ( 29404214) High density lipoprotein cholesterol levels ( 31217584) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Hippocampal volume in mild cognitive impairment ( 29274321) Inflammatory bowel disease ( 28067908) Low density lipoprotein cholesterol levels ( 32154731) Multiple myeloma ( 26007630) Multiple myeloma and monoclonal gammopathy ( 26007630) Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease ( 29748315) Total cholesterol levels ( 28334899) Triglyceride levels ( 34074324) Ulcerative colitis ( 28067908) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Hip circumference adjusted for BMI ( 34021172) Prostate cancer ( 25217961) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		24 interacting genes: APP CLTC DAZAP2 DNAL4 EEA1 ILVBL LITAF LRRC20 MAP3K1 MYO6 NAA11 NEDD4 OGT PILRA PTBP2 RPS27 SMURF1 SSBP2 TAB1 TOLLIP UBC UBE2D1 ZFYVE16 ZNF512B	20 interacting genes: ACTA1 APC CALCOCO2 CALM2 CDC42 CDH1 CLTB DAB1 DAB2 DLG1 GIPC1 LRCH3 OPTN PAK1 PAK3 RNF11 TOM1 TOM1L2 UBC WBP2
Entrez ID		10043	4646
HPRD ID		05265	02985
Ensembl ID		ENSG00000100284	ENSG00000196586
Uniprot IDs		B3KUF5 O60784	Q9UM54
PDB IDs		1ELK 1WRD 2N2N 2N9D 6J56	2N0Z 2N10 2N11 2N12 2N13 6E5N 6J56
Enriched GO Terms of Interacting Partners?
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