MYO6 and CLTB

Number of citations of the paper that reports this interaction (PubMedID 26496610)
430

Data Source:
BioGRID (affinity chromatography technology, pull down)

		MYO6	CLTB
Description		myosin VI	clathrin light chain B
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleus Nucleoplasm Cytoplasm Lysosomal Membrane Golgi Apparatus Cytosol Actin Filament Plasma Membrane Microvillus Clathrin-coated Pit Cell Cortex Actin Cytoskeleton Membrane Unconventional Myosin Complex RNA Polymerase II, Holoenzyme Endocytic Vesicle Filopodium Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Filamentous Actin Nuclear Membrane Vesicle Ruffle Membrane Apical Part Of Cell Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome	Trans-Golgi Network Cytosol Plasma Membrane Clathrin Coat Clathrin Vesicle Coat Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Coat Of Coated Pit Synaptic Vesicle Membrane Intracellular Membrane-bounded Organelle Clathrin-coated Endocytic Vesicle Ciliary Membrane Presynaptic Endocytic Zone Membrane Postsynaptic Endocytic Zone Cytoplasmic Component
	Molecular Function	Microfilament Motor Activity Cytoskeletal Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding ADP Binding Actin Filament Binding Minus-end Directed Microfilament Motor Activity	Structural Molecule Activity Protein Binding Clathrin Heavy Chain Binding Peptide Binding
	Biological Process	Intracellular Protein Transport Endocytosis Actin Filament Organization Sensory Perception Of Sound Response To Xenobiotic Stimulus Actin Filament-based Movement Vesicle Transport Along Actin Filament DNA Damage Response, Signal Transduction By P53 Class Mediator Inner Ear Morphogenesis Inner Ear Auditory Receptor Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Secretion	Intracellular Protein Transport Clathrin Coat Assembly Clathrin-dependent Endocytosis
Pathways		Gap junction degradation Trafficking of AMPA receptors RHOBTB2 GTPase cycle RHOU GTPase cycle RHOBTB1 GTPase cycle	Gap junction degradation Formation of annular gap junctions EPH-ephrin mediated repulsion of cells Lysosome Vesicle Biogenesis WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172) Prostate cancer ( 25217961) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Waist circumference adjusted for body mass index ( 34021172)	Obesity-related traits ( 23251661)
Interacting Genes		20 interacting genes: ACTA1 APC CALCOCO2 CALM2 CDC42 CDH1 CLTB DAB1 DAB2 DLG1 GIPC1 LRCH3 OPTN PAK1 PAK3 RNF11 TOM1 TOM1L2 UBC WBP2	9 interacting genes: CALM1 CLTC CSNK2A1 CSNK2A2 HIP1 HIP1R HTR4 MYO6 PQBP1
Entrez ID		4646	1212
HPRD ID		02985	00352
Ensembl ID		ENSG00000196586	ENSG00000175416
Uniprot IDs		Q9UM54	A0A024R7S3 P09497
PDB IDs		2N0Z 2N10 2N11 2N12 2N13 6E5N 6J56
Enriched GO Terms of Interacting Partners?
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