SGSM2 and RPS25

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SGSM2	RPS25
Gene Name		small G protein signaling modulator 2	ribosomal protein S25
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Nucleus Nucleolus Cytoplasm Cytosol Ribosome Small Ribosomal Subunit Cytosolic Small Ribosomal Subunit Extracellular Vesicular Exosome
	Molecular Function	Rab GTPase Activator Activity Rab GTPase Binding	RNA Binding Protein Binding Poly(A) RNA Binding
	Biological Process	Positive Regulation Of Rab GTPase Activity Late Endosome To Golgi Transport	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process
Pathways			Nonsense-Mediated Decay (NMD) Translation initiation complex formation Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosomal scanning and start codon recognition Formation of the ternary complex, and subsequently, the 43S complex Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Aortic root size ( 19584346) Proinsulin levels ( 21873549)
Protein-Protein Interactions		14 interactors: AFP CA12 CELSR3 CHD3 EGFR FNBP1L GDPD2 ILF2 KHDRBS3 MPP1 PNO1 PTN RGMA RPS25	5 interactors: APP HAP1 SGSM2 THAP1 UPF2
Entrez ID		9905	6230
HPRD ID		15284	01593
Ensembl ID		ENSG00000141258
Uniprot IDs		B9A6J3 O43147	P62851
PDB IDs			3J3A
Enriched GO Terms of Interacting Partners?			Axon Cargo Transport Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Intracellular Transport Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly Positive Regulation Of Mitotic Cell Cycle Regulation Of Receptor Activity Establishment Of Localization In Cell Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Synaptic Growth At Neuromuscular Junction Cellular Localization Regulation Of Cell Cycle Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Collateral Sprouting In Absence Of Injury Positive Regulation Of Cilium Assembly Late Endosome To Golgi Transport Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Positive Regulation Of Cell Cycle RNA Metabolic Process Microtubule-based Movement Hypothalamus Cell Differentiation Neuron Remodeling Exocytosis Gene Expression Vesicle-mediated Transport Negative Regulation Of Beta-amyloid Formation Retrograde Axon Cargo Transport Negative Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Microtubule-based Movement Response To Oxidative Stress Positive Regulation Of Synaptic Transmission, GABAergic Forebrain Development Aromatic Compound Catabolic Process Nucleotide-excision Repair, DNA Gap Filling Negative Regulation Of Smooth Muscle Cell Migration Posttranscriptional Regulation Of Gene Expression DNA Demethylation
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