MAML1 and NOTCH3

Number of citations of the paper that reports this interaction (PMID 11101851)
117

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		MAML1	NOTCH3
Gene Name		mastermind-like 1 (Drosophila)	notch 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	MAML1-RBP-Jkappa- ICN1 Complex Nucleus Nucleoplasm Nuclear Speck Intracellular Membrane-bounded Organelle	Golgi Membrane Extracellular Region Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Actin Cytoskeleton Integral Component Of Membrane Receptor Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding Protein Kinase Binding Peptide Antigen Binding	Calcium Ion Binding Protein Binding Enzyme Binding
	Biological Process	Atrioventricular Node Development Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Gene Expression Positive Regulation Of Myotube Differentiation Myoblast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Atrioventricular Node Cell Development	Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Notch Signaling Pathway Notch Receptor Processing Gene Expression Forebrain Development Negative Regulation Of Neuron Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Neuron Fate Commitment Glomerular Capillary Formation
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH NOTCH2 intracellular domain regulates transcription Notch-HLH transcription pathway Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH2 Generic Transcription Pathway Pre-NOTCH Transcription and Translation Signaling by NOTCH1 Pre-NOTCH Expression and Processing Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer	Notch-HLH transcription pathway Generic Transcription Pathway Pre-NOTCH Processing in Golgi Pre-NOTCH Transcription and Translation Signaling by NOTCH Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Expression and Processing Signaling by NOTCH3
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: CDK8 CREBBP EP300 HDAC9 NOTCH1 NOTCH2 NOTCH3 NOTCH4 PIAS1 RBPJ	40 interactors: BAG2 BTF3L4 C1QL1 C8orf76 CBFA2T2 CHUK CNTD1 CPNE6 CRIP2 CSNK2B DLL1 EGFL7 FBLN1 GGT6 JAG1 JAG2 KAT2B MAML1 MAML2 MAML3 MPPED2 MYC NEDD9 PPIA PSEN1 PSEN2 RBPJ RET RMI2 SCGB3A1 SLC39A1 SNW1 SNX19 SORBS3 SPTLC2 TMEM108 TNNT2 TPT1 WDR25 XKR8
Entrez ID		9794	4854
HPRD ID		05665	02607
Ensembl ID		ENSG00000161021	ENSG00000074181
Uniprot IDs		Q92585	Q9UM47
PDB IDs		2F8X 3NBN 3V79
Enriched GO Terms of Interacting Partners?		Notch Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription, DNA-templated Notch Receptor Processing RNA Biosynthetic Process Interleukin-4 Secretion Positive Regulation Of Transcription Of Notch Receptor Target Regulation Of Transcription From RNA Polymerase II Promoter Cell Surface Receptor Signaling Pathway RNA Metabolic Process Interleukin-4 Production Notch Signaling Involved In Heart Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cardiovascular System Development Transcription From RNA Polymerase II Promoter Regulation Of Cell Differentiation Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Cell Fate Commitment Nucleobase-containing Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Cell Differentiation Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Immune System Process Defense Response Negative Regulation Of Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Inflammatory Response To Antigenic Stimulus Cytokine Secretion Stem Cell Maintenance Regulation Of Muscle Cell Differentiation Signal Transduction Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process N-terminal Peptidyl-lysine Acetylation	Notch Signaling Pathway Notch Receptor Processing Transcription Initiation From RNA Polymerase II Promoter Tissue Morphogenesis DNA-templated Transcription, Initiation Morphogenesis Of An Epithelium Tissue Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Epithelium Development Positive Regulation Of Metabolic Process Immune System Development Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression System Development Positive Regulation Of Cellular Biosynthetic Process Multicellular Organismal Development Hemopoiesis Cell Surface Receptor Signaling Pathway Anatomical Structure Development Cell Fate Commitment Developmental Process Tube Development Positive Regulation Of Signal Transduction Cell Differentiation Regulation Of Cell Differentiation Organ Morphogenesis Auditory Receptor Cell Differentiation Heart Morphogenesis Epithelial Tube Morphogenesis Membrane Protein Proteolysis Myeloid Leukocyte Differentiation Positive Regulation Of Transcription Of Notch Receptor Target Hair Cell Differentiation Auditory Receptor Cell Fate Commitment Stem Cell Development Tube Morphogenesis Myoblast Differentiation Cell Development Endothelial Tube Morphogenesis Generation Of Neurons Notch Signaling Involved In Heart Development Amyloid Precursor Protein Catabolic Process Nervous System Development Stem Cell Maintenance Negative Regulation Of Cell Differentiation Stem Cell Differentiation Inner Ear Receptor Cell Differentiation
Tagcloud ?		adam33 allergen allergens allergic black boston cnot6 cockroach dataset dust fcer1a genotypic haplotype haplotypes house il5ra jak3 marginally mite nod1 rs11739089 rs12136904t rs6665683 rs6665683t rs7851969 sensitization sensitizations snps strongest	barrett cdx1 columnar dnmaml esophagus formerly goblet hes1 jag1 k13 k14 k18 k19 k20 k5 k8 keratins klf4 mastermind metaplasia muc17 muc2 muc3b muc5b mucins organotypic transdifferentiation
Tagcloud (Difference) ?		adam33 allergen allergens allergic black boston cnot6 cockroach dataset dust fcer1a genotypic haplotype haplotypes house il5ra jak3 marginally mite nod1 rs11739089 rs12136904t rs6665683 rs6665683t rs7851969 sensitization sensitizations snps strongest	barrett cdx1 columnar dnmaml esophagus formerly goblet hes1 jag1 k13 k14 k18 k19 k20 k5 k8 keratins klf4 mastermind metaplasia muc17 muc2 muc3b muc5b mucins organotypic transdifferentiation
Tagcloud (Intersection) ?