MAML1 and NOTCH4

Number of citations of the paper that reports this interaction (PMID 11101851)
117

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		MAML1	NOTCH4
Gene Name		mastermind-like 1 (Drosophila)	notch 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	MAML1-RBP-Jkappa- ICN1 Complex Nucleus Nucleoplasm Nuclear Speck Intracellular Membrane-bounded Organelle	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Surface
	Molecular Function	Transcription Coactivator Activity Protein Binding Protein Kinase Binding Peptide Antigen Binding	Receptor Activity Calcium Ion Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Atrioventricular Node Development Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Gene Expression Positive Regulation Of Myotube Differentiation Myoblast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Atrioventricular Node Cell Development	Patterning Of Blood Vessels Cell Fate Determination Morphogenesis Of A Branching Structure Endothelial Cell Morphogenesis Transcription Initiation From RNA Polymerase II Promoter Notch Signaling Pathway Notch Receptor Processing Positive Regulation Of Transcription Of Notch Receptor Target Embryo Development Gene Expression Hemopoiesis Cell Differentiation Mammary Gland Development Negative Regulation Of Cell Differentiation Negative Regulation Of Endothelial Cell Differentiation Positive Regulation Of Transcription, DNA-templated
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH NOTCH2 intracellular domain regulates transcription Notch-HLH transcription pathway Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH2 Generic Transcription Pathway Pre-NOTCH Transcription and Translation Signaling by NOTCH1 Pre-NOTCH Expression and Processing Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer	Notch-HLH transcription pathway Signaling by NOTCH4 Generic Transcription Pathway Pre-NOTCH Processing in Golgi Pre-NOTCH Transcription and Translation Signaling by NOTCH Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Expression and Processing
Drugs
Diseases
GWAS			Age-related macular degeneration ( 22694956) Asthma ( 21804548) Circulating myeloperoxidase levels (serum) ( 23620142) Crohn's disease ( 23266558) Epstein-Barr virus immune response (EBNA-1) ( 23326239) HIV-1 control ( 20041166) Obesity-related traits ( 23251661) Prostate cancer ( 23535732) Schizophrenia ( 19571808 23894747) Systemic lupus erythematosus ( 21408207) Systemic sclerosis ( 21779181)
Protein-Protein Interactions		10 interactors: CDK8 CREBBP EP300 HDAC9 NOTCH1 NOTCH2 NOTCH3 NOTCH4 PIAS1 RBPJ	13 interactors: DLL4 EGFL7 FBXW7 MAML1 MAML2 MAML3 PSEN1 PSEN2 RBPJ SMAD2 SMAD3 SMAD4 TCEB1
Entrez ID		9794	4855
HPRD ID		05665	01290
Ensembl ID		ENSG00000161021	ENSG00000204301
Uniprot IDs		Q92585	Q99466
PDB IDs		2F8X 3NBN 3V79
Enriched GO Terms of Interacting Partners?		Notch Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription, DNA-templated Notch Receptor Processing RNA Biosynthetic Process Interleukin-4 Secretion Positive Regulation Of Transcription Of Notch Receptor Target Regulation Of Transcription From RNA Polymerase II Promoter Cell Surface Receptor Signaling Pathway RNA Metabolic Process Interleukin-4 Production Notch Signaling Involved In Heart Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cardiovascular System Development Transcription From RNA Polymerase II Promoter Regulation Of Cell Differentiation Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Cell Fate Commitment Nucleobase-containing Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Cell Differentiation Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Immune System Process Defense Response Negative Regulation Of Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Inflammatory Response To Antigenic Stimulus Cytokine Secretion Stem Cell Maintenance Regulation Of Muscle Cell Differentiation Signal Transduction Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process N-terminal Peptidyl-lysine Acetylation	Notch Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Cardiovascular System Development Tube Development Positive Regulation Of Metabolic Process Pattern Specification Process Regulation Of Transcription From RNA Polymerase II Promoter Heart Development Transcription From RNA Polymerase II Promoter Cell Fate Commitment SMAD Protein Complex Assembly Positive Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Surface Receptor Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Tube Morphogenesis Positive Regulation Of Cellular Metabolic Process Somitogenesis Regulation Of ERBB Signaling Pathway Heart Morphogenesis Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Somite Development Anterior/posterior Pattern Specification Notch Receptor Processing Regulation Of Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Epidermal Growth Factor-activated Receptor Activity Pericardium Development Segmentation Blood Vessel Lumenization Organ Morphogenesis Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Dorsal/ventral Pattern Formation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Epithelium Development Embryonic Morphogenesis Regulation Of RNA Metabolic Process Tissue Morphogenesis Anatomical Structure Morphogenesis Negative Regulation Of Cell Proliferation Tissue Development Cell Differentiation Embryo Development Positive Regulation Of BMP Signaling Pathway Epithelial Tube Morphogenesis
Tagcloud ?		adam33 allergen allergens allergic black boston cnot6 cockroach dataset dust fcer1a genotypic haplotype haplotypes house il5ra jak3 marginally mite nod1 rs11739089 rs12136904t rs6665683 rs6665683t rs7851969 sensitization sensitizations snps strongest	antileukemic antiproliferative apigenin baicalein cdc2 cdk4 cdk6 chrysin division dysregulated dysregulation flavonoids galangin genistein hl illustrated jurkat k562 luteolin naringenin nb4 potencies ppa proteomic scutellarin suppresses u937 ubiquitously xiap
Tagcloud (Difference) ?		adam33 allergen allergens allergic black boston cnot6 cockroach dataset dust fcer1a genotypic haplotype haplotypes house il5ra jak3 marginally mite nod1 rs11739089 rs12136904t rs6665683 rs6665683t rs7851969 sensitization sensitizations snps strongest	antileukemic antiproliferative apigenin baicalein cdc2 cdk4 cdk6 chrysin division dysregulated dysregulation flavonoids galangin genistein hl illustrated jurkat k562 luteolin naringenin nb4 potencies ppa proteomic scutellarin suppresses u937 ubiquitously xiap
Tagcloud (Intersection) ?