GSTO1 and EEF1G

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		GSTO1	EEF1G
Gene Name		glutathione S-transferase omega 1	eukaryotic translation elongation factor 1 gamma
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Vesicular Exosome	Nucleus Cytosol Membrane Extracellular Vesicular Exosome
	Molecular Function	Glutathione Transferase Activity Protein Binding Oxidoreductase Activity Glutathione Dehydrogenase (ascorbate) Activity Methylarsonate Reductase Activity	Translation Elongation Factor Activity Protein Binding
	Biological Process	Xenobiotic Metabolic Process Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Positive Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion L-ascorbic Acid Metabolic Process Xenobiotic Catabolic Process Small Molecule Metabolic Process Oxidation-reduction Process Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cellular Response To Arsenic-containing Substance Glutathione Derivative Biosynthetic Process	Translation Translational Elongation Response To Virus Gene Expression Cellular Protein Metabolic Process
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective UGT1A4 causes hyperbilirubinemia Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Metabolic disorders of biological oxidation enzymes Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective AMN causes hereditary megaloblastic anemia 1 Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency) Defects in cobalamin (B12) metabolism Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective GIF causes intrinsic factor deficiency Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Glutathione conjugation Vitamin C (ascorbate) metabolism Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Phase II conjugation Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in vitamin and cofactor metabolism	Translation Eukaryotic Translation Elongation
Drugs		Glutathione
Diseases
GWAS
Protein-Protein Interactions		6 interactors: APP EEF1G KAT5 KIAA1377 RBM48 SETDB1	87 interactors: ABCC9 ADAP2 AKT1 ARF1 ARIH2 C11orf58 C1orf174 CARS CBX8 CCDC106 CCT7 CDC42 CDK2AP2 CDK5RAP2 CHFR CRELD1 CSTF2 CXCL13 DKC1 DLEU1 DRD3 ECH1 EEF1B2 EEF1D EEF1DP3 EFNA1 EGFR EID2B ENOX1 FAM195A FEN1 FOXG1 GADD45A GADD45G GET4 GSK3B GSTO1 HARS HDAC5 HLTF HMOX2 HNRNPH3 ILF2 KARS KLHL18 LARS LZTS1 MED31 MLH1 MTNR1A MVD NADK NCK2 NDRG1 NUDT21 NUDT3 NUP85 OGFOD2 PDCD5 PHACTR3 PLEKHA4 PLGRKT PSMD11 PTK2 PTPN4 PTPRS RBM6 RECQL5 RGL2 RPL4P5 RPS28 SAT1 SKIL SNAPIN SNRPD2 TNNT1 TP53I3 TRIB3 TRIM55 TRIM63 TUBB3 UCHL5 WDR33 YWHAG ZBED8 ZDHHC17 ZNF24
Entrez ID		9446	1937
HPRD ID		10401	11745
Ensembl ID		ENSG00000148834	ENSG00000254772
Uniprot IDs		P78417	P26641 Q53YD7
PDB IDs		1EEM 3LFL 3VLN 4IS0	1PBU
Enriched GO Terms of Interacting Partners?			Gene Expression Cellular Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Macromolecule Biosynthetic Process Cellular Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Macromolecule Biosynthetic Process Biosynthetic Process Positive Regulation Of Signal Transduction Cell Cycle Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Intracellular Transport Regulation Of Cell Development Chemotaxis Regulation Of Protein Kinase Activity Cell Cycle Regulation Of Endothelial Cell Migration Positive Regulation Of Mitochondrion Organization Regulation Of Kinase Activity Translation Negative Regulation Of Transferase Activity Regulation Of Neuron Differentiation Negative Regulation Of Protein Kinase Activity Negative Regulation Of Protein Phosphorylation Regulation Of Neurogenesis Positive Regulation Of Transferase Activity Regulation Of Intracellular Transport Cellular Response To Mechanical Stimulus Nervous System Development Cellular Response To Growth Factor Stimulus Negative Regulation Of Kinase Activity MRNA Polyadenylation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Protein Binding Regulation Of Epithelial Cell Migration Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein Metabolic Process MRNA 3'-end Processing Response To Growth Factor Regulation Of Signal Transduction Mitotic Cell Cycle Immune System Process Regulation Of Cell Projection Organization Response To UV-A Regulation Of Catalytic Activity
Tagcloud ?		1a 1beta attenuates blocks catalase catalytically catalyze deglutathionylation generates glutathione j774 kappabeta lipopolysaccharide lps maintain mediates nadph omega oxidase peroxidase proinflammatory protect redox ros shrna tlr4 tnfalpha toll transferase	4egi antiporter antitumoral apparatus atf4 attenuation bip client consequent cyclophilin cystine eef1a eif4a favoring filters gcn2 hsp migrate nascent pores proteostasis ribavirin ribosomes sensitizes sorcin tbp7 transwell trap1 xct
Tagcloud (Difference) ?		1a 1beta attenuates blocks catalase catalytically catalyze deglutathionylation generates glutathione j774 kappabeta lipopolysaccharide lps maintain mediates nadph omega oxidase peroxidase proinflammatory protect redox ros shrna tlr4 tnfalpha toll transferase	4egi antiporter antitumoral apparatus atf4 attenuation bip client consequent cyclophilin cystine eef1a eif4a favoring filters gcn2 hsp migrate nascent pores proteostasis ribavirin ribosomes sensitizes sorcin tbp7 transwell trap1 xct
Tagcloud (Intersection) ?