GSTO1

Gene Name		glutathione S-transferase omega 1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	Glutathione Transferase Activity Protein Binding Oxidoreductase Activity Glutathione Dehydrogenase (ascorbate) Activity Methylarsonate Reductase Activity
	Biological Process	Xenobiotic Metabolic Process Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Positive Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion L-ascorbic Acid Metabolic Process Xenobiotic Catabolic Process Small Molecule Metabolic Process Oxidation-reduction Process Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cellular Response To Arsenic-containing Substance Glutathione Derivative Biosynthetic Process
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective UGT1A4 causes hyperbilirubinemia Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Metabolic disorders of biological oxidation enzymes Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective AMN causes hereditary megaloblastic anemia 1 Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency) Defects in cobalamin (B12) metabolism Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective GIF causes intrinsic factor deficiency Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Glutathione conjugation Vitamin C (ascorbate) metabolism Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Phase II conjugation Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in vitamin and cofactor metabolism
Drugs		Glutathione
Diseases
GWAS
Protein-protein Interactions		6 interactors: APP EEF1G KAT5 KIAA1377 RBM48 SETDB1
Entrez ID		9446
HPRD ID		10401
Ensembl ID		ENSG00000148834
Uniprot IDs		P78417
PDB IDs		1EEM 3LFL 3VLN 4IS0
Enriched GO Terms of Interacting Partners?
Tagcloud ?		1a 1beta attenuates blocks catalase catalytically catalyze deglutathionylation generates glutathione j774 kappabeta lipopolysaccharide lps maintain mediates nadph omega oxidase peroxidase proinflammatory protect redox ros shrna tlr4 tnfalpha toll transferase