EEF1G and PTPN4

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		EEF1G	PTPN4
Gene Name		eukaryotic translation elongation factor 1 gamma	protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Membrane Extracellular Vesicular Exosome	Cytoplasm Cytoskeleton Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Translation Elongation Factor Activity Protein Binding	Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding Cytoskeletal Protein Binding
	Biological Process	Translation Translational Elongation Response To Virus Gene Expression Cellular Protein Metabolic Process	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation
Pathways		Translation Eukaryotic Translation Elongation
Drugs			Alendronate
Diseases
GWAS
Protein-Protein Interactions		87 interactors: ABCC9 ADAP2 AKT1 ARF1 ARIH2 C11orf58 C1orf174 CARS CBX8 CCDC106 CCT7 CDC42 CDK2AP2 CDK5RAP2 CHFR CRELD1 CSTF2 CXCL13 DKC1 DLEU1 DRD3 ECH1 EEF1B2 EEF1D EEF1DP3 EFNA1 EGFR EID2B ENOX1 FAM195A FEN1 FOXG1 GADD45A GADD45G GET4 GSK3B GSTO1 HARS HDAC5 HLTF HMOX2 HNRNPH3 ILF2 KARS KLHL18 LARS LZTS1 MED31 MLH1 MTNR1A MVD NADK NCK2 NDRG1 NUDT21 NUDT3 NUP85 OGFOD2 PDCD5 PHACTR3 PLEKHA4 PLGRKT PSMD11 PTK2 PTPN4 PTPRS RBM6 RECQL5 RGL2 RPL4P5 RPS28 SAT1 SKIL SNAPIN SNRPD2 TNNT1 TP53I3 TRIB3 TRIM55 TRIM63 TUBB3 UCHL5 WDR33 YWHAG ZBED8 ZDHHC17 ZNF24	11 interactors: ATRX CRK EEF1A1 EEF1G GRID2 GRIN2A KAT5 LPL PRSS1 TK1 ZZEF1
Entrez ID		1937	5775
HPRD ID		11745	01471
Ensembl ID		ENSG00000254772	ENSG00000088179
Uniprot IDs		P26641 Q53YD7	P29074
PDB IDs		1PBU	2CS5 2I75 2VPH 3NFK 3NFL
Enriched GO Terms of Interacting Partners?		Gene Expression Cellular Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Macromolecule Biosynthetic Process Cellular Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Macromolecule Biosynthetic Process Biosynthetic Process Positive Regulation Of Signal Transduction Cell Cycle Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Intracellular Transport Regulation Of Cell Development Chemotaxis Regulation Of Protein Kinase Activity Cell Cycle Regulation Of Endothelial Cell Migration Positive Regulation Of Mitochondrion Organization Regulation Of Kinase Activity Translation Negative Regulation Of Transferase Activity Regulation Of Neuron Differentiation Negative Regulation Of Protein Kinase Activity Negative Regulation Of Protein Phosphorylation Regulation Of Neurogenesis Positive Regulation Of Transferase Activity Regulation Of Intracellular Transport Cellular Response To Mechanical Stimulus Nervous System Development Cellular Response To Growth Factor Stimulus Negative Regulation Of Kinase Activity MRNA Polyadenylation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Protein Binding Regulation Of Epithelial Cell Migration Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein Metabolic Process MRNA 3'-end Processing Response To Growth Factor Regulation Of Signal Transduction Mitotic Cell Cycle Immune System Process Regulation Of Cell Projection Organization Response To UV-A Regulation Of Catalytic Activity	Startle Response Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Response To Organic Substance Glutamate Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Regulation Of Excitatory Postsynaptic Membrane Potential Fetal Process Involved In Parturition Negative Regulation Of Telomeric RNA Transcription From RNA Pol II Promoter Regulation Of Postsynaptic Membrane Potential Response To External Stimulus Response To Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Signal Transduction In Response To DNA Damage Response To Radiation Skeletal Muscle Cell Proliferation Signal Transduction By P53 Class Mediator Membrane Depolarization Chylomicron Remodeling Cellular Response To Hydroxyurea Neuromuscular Process Directional Locomotion Positive Regulation Of Nuclear Cell Cycle DNA Replication Translational Elongation Response To Cortisol Thymidine Metabolic Process Positive Regulation Of Sequestering Of Triglyceride Deoxyribonucleoside Monophosphate Biosynthetic Process Very-low-density Lipoprotein Particle Remodeling Pyrimidine Nucleoside Salvage Pyrimidine-containing Compound Salvage Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Telomere Maintenance Triglyceride-rich Lipoprotein Particle Remodeling Cerebellar Granule Cell Differentiation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Regulation Of Membrane Potential DNA Damage Response, Signal Transduction Resulting In Transcription Response To Hormone Heterocycle Metabolic Process Prepulse Inhibition Serotonin Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Stimulus Biosynthetic Process Replication Fork Processing Sleep Positive Regulation Of DNA-dependent DNA Replication Cerebellar Granular Layer Morphogenesis Parturition
Tagcloud ?		4egi antiporter antitumoral apparatus atf4 attenuation bip client consequent cyclophilin cystine eef1a eif4a favoring filters gcn2 hsp migrate nascent pores proteostasis ribavirin ribosomes sensitizes sorcin tbp7 transwell trap1 xct	abrogates adopts analytical angle catalytic communication compact competence conformation disrupting emerging encompassing interdomain mere nmr notion pdz phosphatase physiologically players predominant prevents ray regulators restores scattering strengthens triggers ultracentrifugation
Tagcloud (Difference) ?		4egi antiporter antitumoral apparatus atf4 attenuation bip client consequent cyclophilin cystine eef1a eif4a favoring filters gcn2 hsp migrate nascent pores proteostasis ribavirin ribosomes sensitizes sorcin tbp7 transwell trap1 xct	abrogates adopts analytical angle catalytic communication compact competence conformation disrupting emerging encompassing interdomain mere nmr notion pdz phosphatase physiologically players predominant prevents ray regulators restores scattering strengthens triggers ultracentrifugation
Tagcloud (Intersection) ?