CD3D and CD8A

Number of citations of the paper that reports this interaction (PMID 12215456)
24

Data Source:
HPRD (in vitro, in vivo)

		CD3D	CD8A
Gene Name		CD3d molecule, delta (CD3-TCR complex)	CD8a molecule
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane T Cell Receptor Complex
	Molecular Function	Transcription Coactivator Activity Transmembrane Signaling Receptor Activity Protein Heterodimerization Activity	Protein Binding Coreceptor Activity Protein Kinase Binding MHC Class I Protein Binding Protein Homodimerization Activity
	Biological Process	Cell Surface Receptor Signaling Pathway T Cell Differentiation T Cell Costimulation Positive Thymic T Cell Selection Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Immune Response T Cell Receptor Signaling Pathway	T Cell Mediated Immunity Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Antigen Processing And Presentation T Cell Activation Cytotoxic T Cell Differentiation Regulation Of Immune Response Positive Regulation Of Calcium-mediated Signaling Defense Response To Virus
Pathways		TCR signaling Downstream TCR signaling Generation of second messenger molecules Translocation of ZAP-70 to Immunological synapse Costimulation by the CD28 family PD-1 signaling Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: AP2M1 CANX CD247 CD3E CD3G CD8A CD8B HERPUD1 KCNA3 TRA TRB	17 interactors: B2M CACYBP CD3D CD59 CD8B CDK1 HLA-A HLA-B HLA-C HLA-E HLA-G LAT LCK LGALS1 PTPRC SREK1 SRSF1
Entrez ID		915	925
HPRD ID		01730	01737
Ensembl ID		ENSG00000167286	ENSG00000153563
Uniprot IDs		B0YIY4 P04234	P01732 Q6ZVS2 Q8TAW8
PDB IDs		1XIW	1AKJ 1CD8 1Q69 2HP4 3QZW
Enriched GO Terms of Interacting Partners?		Regulation Of Defense Response To Virus By Virus Immune System Process Regulation Of Immune System Process T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Signaling T Cell Costimulation Cell Communication Regulation Of Defense Response To Virus Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Regulation Of Immune Response T Cell Receptor Signaling Pathway Lymphocyte Activation Antigen Receptor-mediated Signaling Pathway Leukocyte Activation Single Organismal Cell-cell Adhesion Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Endocytosis Clathrin-mediated Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Positive Regulation Of Cell-cell Adhesion Regulation Of Calcium-mediated Signaling Immune Response-activating Cell Surface Receptor Signaling Pathway Antigen Processing And Presentation Regulation Of T Cell Activation Positive Regulation Of Cell Activation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Regulation Of Lymphocyte Activation Cytotoxic T Cell Differentiation Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Signal Transduction Cell Adhesion Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Immune Response Viral Process Synaptic Transmission	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T Cell Mediated Cytotoxicity Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Leukocyte Mediated Cytotoxicity Regulation Of Immune System Process Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Immune Response Positive Regulation Of Adaptive Immune Response Immune System Process Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Regulation Of Adaptive Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Interferon-gamma-mediated Signaling Pathway Regulation Of T Cell Activation Innate Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Cellular Response To Interferon-gamma Positive Regulation Of T Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Lymphocyte Activation Defense Response Response To Interferon-gamma Antigen Processing And Presentation Of Endogenous Antigen Positive Regulation Of Cell-cell Adhesion Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Protection From Natural Killer Cell Mediated Cytotoxicity Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Regulation Of Cell Activation Response To Type I Interferon Positive Regulation Of Cell Activation Antigen Processing And Presentation Of Peptide Antigen Regulation Of Defense Response To Virus By Virus Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Lymphocyte Activation Antigen Processing And Presentation Cell Activation Negative Regulation Of Immune Response Leukocyte Activation T Cell Aggregation T Cell Activation
Tagcloud ?		aurkb bub1b ccnb1 cd247 cd3g cd8a cdc20 cdca8 cenpa cytoscape dihydroxyfluorane epstain generank hindering itgb5 itk kif2c lcp2 limma lymphoblasts mad2l1 nup37 pik3r3 plcg2 prkcq rpa3 softwares vav3 zap70	anthracycline assignment bcs carboplatin cb ccl5 cd21 cd80 ctla4 cxcl13 cxcl9 foxp3 geparsixto hierarchic histopathologic ido1 igkc immunogenicity immunologic immunologically infiltrating lpbc ors pmcb standardization taxane tils tn univariable
Tagcloud (Difference) ?		aurkb bub1b ccnb1 cd247 cd3g cdc20 cdca8 cenpa cytoscape dihydroxyfluorane epstain generank hindering itgb5 itk kif2c lcp2 limma lymphoblasts mad2l1 nup37 pik3r3 plcg2 prkcq rpa3 softwares vav3 zap70	anthracycline assignment bcs carboplatin cb ccl5 cd21 cd80 ctla4 cxcl13 cxcl9 foxp3 geparsixto hierarchic histopathologic ido1 igkc immunogenicity immunologic immunologically infiltrating lpbc ors pmcb standardization taxane tils tn univariable
Tagcloud (Intersection) ?		cd8a