CD3D and CD3G

Number of citations of the paper that reports this interaction (PMID 9485181)
16

Data Source:
HPRD (in vivo, in vitro)

		CD3D	CD3G
Gene Name		CD3d molecule, delta (CD3-TCR complex)	CD3g molecule, gamma (CD3-TCR complex)
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Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex	Plasma Membrane Integral Component Of Plasma Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex
	Molecular Function	Transcription Coactivator Activity Transmembrane Signaling Receptor Activity Protein Heterodimerization Activity	Transmembrane Signaling Receptor Activity Receptor Signaling Complex Scaffold Activity T Cell Receptor Binding Protein Heterodimerization Activity
	Biological Process	Cell Surface Receptor Signaling Pathway T Cell Differentiation T Cell Costimulation Positive Thymic T Cell Selection Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Immune Response T Cell Receptor Signaling Pathway	Protein Complex Assembly Establishment Or Maintenance Of Cell Polarity Cell Surface Receptor Signaling Pathway Protein Transport T Cell Costimulation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis T Cell Activation Innate Immune Response Regulation Of Immune Response T Cell Receptor Signaling Pathway Regulation Of Lymphocyte Apoptotic Process
Pathways		TCR signaling Downstream TCR signaling Generation of second messenger molecules Translocation of ZAP-70 to Immunological synapse Costimulation by the CD28 family PD-1 signaling Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System	Generation of second messenger molecules Downstream TCR signaling Costimulation by the CD28 family Translocation of ZAP-70 to Immunological synapse TCR signaling PD-1 signaling Role of phospholipids in phagocytosis Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Fcgamma receptor (FCGR) dependent phagocytosis Phosphorylation of CD3 and TCR zeta chains FCGR activation Regulation of actin dynamics for phagocytic cup formation Adaptive Immune System Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: AP2M1 CANX CD247 CD3E CD3G CD8A CD8B HERPUD1 KCNA3 TRA TRB	5 interactors: CD3D CD3E TRA TRB TRD
Entrez ID		915	917
HPRD ID		01730	07037
Ensembl ID		ENSG00000167286
Uniprot IDs		B0YIY4 P04234	B0YIY5 P09693
PDB IDs		1XIW	1SY6
Enriched GO Terms of Interacting Partners?		Regulation Of Defense Response To Virus By Virus Immune System Process Regulation Of Immune System Process T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Signaling T Cell Costimulation Cell Communication Regulation Of Defense Response To Virus Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Regulation Of Immune Response T Cell Receptor Signaling Pathway Lymphocyte Activation Antigen Receptor-mediated Signaling Pathway Leukocyte Activation Single Organismal Cell-cell Adhesion Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Endocytosis Clathrin-mediated Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Positive Regulation Of Cell-cell Adhesion Regulation Of Calcium-mediated Signaling Immune Response-activating Cell Surface Receptor Signaling Pathway Antigen Processing And Presentation Regulation Of T Cell Activation Positive Regulation Of Cell Activation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Regulation Of Lymphocyte Activation Cytotoxic T Cell Differentiation Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Signal Transduction Cell Adhesion Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Immune Response Viral Process Synaptic Transmission	Thymic T Cell Selection T Cell Selection T Cell Differentiation In Thymus T Cell Costimulation T Cell Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway T Cell Differentiation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Lymphocyte Differentiation Positive Regulation Of Cell-cell Adhesion T Cell Aggregation T Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Lymphocyte Aggregation Leukocyte Aggregation Regulation Of T Cell Activation Positive Regulation Of Cell Activation Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Leukocyte Differentiation Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Lymphocyte Activation Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Leukocyte Activation Positive Regulation Of T Cell Anergy Single Organismal Cell-cell Adhesion Regulation Of Cell Adhesion Hemopoiesis Regulation Of T Cell Anergy Positive Regulation Of Immune Response Positive Thymic T Cell Selection Cell Activation Immune System Development Positive Regulation Of T Cell Tolerance Induction Negative Thymic T Cell Selection Signal Complex Assembly Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Interleukin-2 Biosynthetic Process Negative T Cell Selection Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Interleukin-4 Production Regulation Of Interleukin-2 Biosynthetic Process Positive T Cell Selection Positive Regulation Of Calcium-mediated Signaling
Tagcloud ?		aurkb bub1b ccnb1 cd247 cd3g cd8a cdc20 cdca8 cenpa cytoscape dihydroxyfluorane epstain generank hindering itgb5 itk kif2c lcp2 limma lymphoblasts mad2l1 nup37 pik3r3 plcg2 prkcq rpa3 softwares vav3 zap70	aurkb bub1b ccnb1 cd247 cd3d cd8a cdc20 cdca8 cenpa cytoscape dihydroxyfluorane epstain generank hindering itgb5 itk kif2c lcp2 limma lymphoblasts mad2l1 nup37 pik3r3 plcg2 prkcq rpa3 softwares vav3 zap70
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		aurkb bub1b ccnb1 cd247 cd3d cd3g cd8a cdc20 cdca8 cenpa cytoscape dihydroxyfluorane epstain generank hindering itgb5 itk kif2c lcp2 limma lymphoblasts mad2l1 nup37 pik3r3 plcg2 prkcq rpa3 softwares vav3 zap70