NMI and STAT5A

Number of citations of the paper that reports this interaction (PMID 9989503)
39

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		NMI	STAT5A
Gene Name		N-myc (and STAT) interactor	signal transducer and activator of transcription 5A
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm	Nucleoplasm Cytosol
	Molecular Function	Transcription Cofactor Activity Protein Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Binding
	Biological Process	Transcription From RNA Polymerase II Promoter Inflammatory Response JAK-STAT Cascade Regulation Of Nucleic Acid-templated Transcription	Allantoin Metabolic Process Luteinization Natural Killer Cell Differentiation Citrate Metabolic Process 2-oxoglutarate Metabolic Process Succinate Metabolic Process Oxaloacetate Metabolic Process Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Isoleucine Metabolic Process Valine Metabolic Process Creatine Metabolic Process Fatty Acid Metabolic Process JAK-STAT Cascade Female Pregnancy Lactation Peptidyl-tyrosine Phosphorylation Regulation Of Steroid Metabolic Process Taurine Metabolic Process Lipid Storage Regulation Of Epithelial Cell Differentiation Positive Regulation Of Natural Killer Cell Differentiation Negative Regulation Of Mast Cell Apoptotic Process T Cell Differentiation In Thymus Prolactin Signaling Pathway Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Activated T Cell Proliferation T Cell Homeostasis Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of B Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Creatinine Metabolic Process Development Of Secondary Female Sexual Characteristics Development Of Secondary Male Sexual Characteristics Peyer's Patch Development Positive Regulation Of Inflammatory Response Positive Regulation Of Mast Cell Differentiation JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Prostate Gland Epithelium Morphogenesis Epithelial Cell Differentiation Involved In Prostate Gland Development Mammary Gland Epithelium Development Positive Regulation Of Mast Cell Proliferation Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus
Pathways			Signaling by PDGF Signaling by FGFR in disease Cytokine Signaling in Immune system Signaling by ERBB4 Signaling by SCF-KIT Signaling by Interleukins Nuclear signaling by ERBB4 Downstream signal transduction Signaling by FGFR1 mutants Interleukin-7 signaling Signaling by FGFR mutants Interleukin-2 signaling Prolactin receptor signaling Signaling by FGFR1 fusion mutants Interleukin-3, 5 and GM-CSF signaling Signaling by Leptin Growth hormone receptor signaling
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		44 interactors: BRCA1 BRMS1 C1orf216 C9orf72 CDKN2A CNKSR3 COPS7B CYP2E1 EMILIN1 GCSH GOLGA8EP HDDC3 HGS HHLA3 HOXC9 HSPA8 IFI35 KDM1A LCA5L LSM4 MAD2L1BP MTMR6 MTMR9 MYC MYCN NECAP2 POMZP3 PSMA1 SCEL SFR1 SNAPC5 SOX10 STAT1 STAT3 STAT4 STAT5A STAT5B STAT6 TRAF5 TRIP12 TUBA3C TUBA3E TXLNA TXLNB	72 interactors: AQP11 BMX BRCA1 BRCA2 BTK CBL CCR5 CD247 CEBPB CENPJ CRK CRKL CSNK2B CTLA4 CYP2C9 EGFR EP300 EPAS1 EPOR ERBB4 ESR1 ESR2 FN1 GHR GLUD1 GNB2 HELZ IL2RB IL2RG IL7R INSR JAK1 JAK2 JAK3 KIT LCK LEF1 MAGEA12 MAPK1 MAPK3 MRPS6 NARF NCOR2 NLK NMI NR3C1 PDGFRA PDGFRB POM121C POU2F1 PPIB PPP2CA PRMT1 PRTFDC1 PTPN1 PTPN11 PTPN2 RBMX SHC1 SRC STAP2 STAT1 STAT3 STAT5B SYK TCF12 TEK TSLP TXNDC11 UGT2B4 WASH2P ZNF596
Entrez ID		9111	6776
HPRD ID		04632	03301
Ensembl ID		ENSG00000123609	ENSG00000126561
Uniprot IDs		Q13287 Q8WTW2	A8K6I5 K7EK35 P42229 Q59GY7
PDB IDs
Enriched GO Terms of Interacting Partners?		JAK-STAT Cascade JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Positive Regulation Of Stem Cell Proliferation Regulation Of Cell Proliferation Response To Growth Hormone Regulation Of Cell Death Positive Regulation Of Transcription, DNA-templated Regulation Of Stem Cell Proliferation Regulation Of Response To DNA Damage Stimulus Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Development Of Secondary Male Sexual Characteristics Cellular Response To Cytokine Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cytokine-mediated Signaling Pathway Negative Regulation Of Transcription, DNA-templated Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Histone H3-K4 Methylation Negative Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Response To Cytokine Regulation Of Apoptotic Process Creatinine Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Erythrocyte Differentiation Negative Regulation Of Gene Expression Positive Regulation Of Metabolic Process Allantoin Metabolic Process Isoleucine Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Cell Proliferation Gene Expression Heterocycle Metabolic Process Taurine Metabolic Process Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of Erythrocyte Differentiation Prolactin Signaling Pathway RNA Metabolic Process Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Gamma-delta T Cell Activation Development Of Secondary Female Sexual Characteristics	Cellular Response To Organic Substance Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Hormone Cell Surface Receptor Signaling Pathway Cellular Response To Hormone Stimulus Protein Autophosphorylation Cellular Response To Stimulus Immune Response Signal Transduction Immune System Process Cellular Response To Organonitrogen Compound Peptidyl-tyrosine Phosphorylation Signaling Cell Communication Cellular Response To Cytokine Stimulus Regulation Of Immune Response Defense Response Response To Cytokine Positive Regulation Of Cellular Metabolic Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Peptidyl-amino Acid Modification Intracellular Signal Transduction Growth Hormone Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Cellular Response To Peptide Hormone Stimulus Response To Stimulus Cellular Response To Growth Hormone Stimulus Innate Immune Response Cellular Response To Peptide Response To Organonitrogen Compound Regulation Of Immune System Process Cellular Response To Growth Factor Stimulus Regulation Of Cell Proliferation Organ Development Response To Growth Factor Cytokine-mediated Signaling Pathway JAK-STAT Cascade Regulation Of MAPK Cascade Response To Peptide Hormone Neurotrophin TRK Receptor Signaling Pathway Response To Peptide Fc Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Kinase Activity Response To Growth Hormone Positive Regulation Of Metabolic Process Neurotrophin Signaling Pathway Anatomical Structure Development
Tagcloud ?		augment augments bait cbp coactivator coil coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks myc potentiate recruitment reveal screen stat stat1 stat2 stat5 stat5b stats yeast	advantaged apor arose b8 ba character coincides committed derive die dn epo epor erythropoietin f3epor homeotic hox hypothesize naturally normally preexisting shortened subclones switch truncated unexplored uniquely
Tagcloud (Difference) ?		augment augments bait cbp coactivator coil coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks myc potentiate recruitment reveal screen stat stat1 stat2 stats yeast	advantaged apor arose b8 ba character coincides committed derive die dn epo epor erythropoietin f3epor homeotic hox hypothesize naturally normally preexisting shortened subclones switch truncated unexplored uniquely
Tagcloud (Intersection) ?		stat5 stat5b