NMI and C9orf72

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		NMI	C9orf72
Gene Name		N-myc (and STAT) interactor	chromosome 9 open reading frame 72
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm	Extracellular Space Nucleus Nucleoplasm Cytoplasm Lysosome Endosome Autophagic Vacuole Actin Cytoskeleton Cytoplasmic Vesicle Intercellular Bridge
	Molecular Function	Transcription Cofactor Activity Protein Binding	Protein Binding Rab GTPase Binding
	Biological Process	Transcription From RNA Polymerase II Promoter Inflammatory Response JAK-STAT Cascade Regulation Of Nucleic Acid-templated Transcription	Endocytosis Autophagy
Pathways
Drugs
Diseases
GWAS			Amyotrophic lateral sclerosis ( 22959728 19734901 20801718) PCA3 expression level ( 23555189)
Protein-Protein Interactions		44 interactors: BRCA1 BRMS1 C1orf216 C9orf72 CDKN2A CNKSR3 COPS7B CYP2E1 EMILIN1 GCSH GOLGA8EP HDDC3 HGS HHLA3 HOXC9 HSPA8 IFI35 KDM1A LCA5L LSM4 MAD2L1BP MTMR6 MTMR9 MYC MYCN NECAP2 POMZP3 PSMA1 SCEL SFR1 SNAPC5 SOX10 STAT1 STAT3 STAT4 STAT5A STAT5B STAT6 TRAF5 TRIP12 TUBA3C TUBA3E TXLNA TXLNB	6 interactors: APP CRX EIF2B2 NMI REL SRPK1
Entrez ID		9111	203228
HPRD ID		04632	12975
Ensembl ID		ENSG00000123609	ENSG00000147894
Uniprot IDs		Q13287 Q8WTW2	Q96LT7 Q9NUW0
PDB IDs
Enriched GO Terms of Interacting Partners?		JAK-STAT Cascade JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Positive Regulation Of Stem Cell Proliferation Regulation Of Cell Proliferation Response To Growth Hormone Regulation Of Cell Death Positive Regulation Of Transcription, DNA-templated Regulation Of Stem Cell Proliferation Regulation Of Response To DNA Damage Stimulus Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Development Of Secondary Male Sexual Characteristics Cellular Response To Cytokine Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cytokine-mediated Signaling Pathway Negative Regulation Of Transcription, DNA-templated Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Histone H3-K4 Methylation Negative Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Response To Cytokine Regulation Of Apoptotic Process Creatinine Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Erythrocyte Differentiation Negative Regulation Of Gene Expression Positive Regulation Of Metabolic Process Allantoin Metabolic Process Isoleucine Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Cell Proliferation Gene Expression Heterocycle Metabolic Process Taurine Metabolic Process Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of Erythrocyte Differentiation Prolactin Signaling Pathway RNA Metabolic Process Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Gamma-delta T Cell Activation Development Of Secondary Female Sexual Characteristics	Gene Expression Defense Response RNA Metabolic Process Positive Regulation Of Photoreceptor Cell Differentiation Response To Stress Synaptic Growth At Neuromuscular Junction Innate Immune Response Collateral Sprouting In Absence Of Injury Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Transcription From RNA Polymerase II Promoter Reproduction Axon Choice Point Recognition Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Stimulus Regulation Of Gene Expression Regulation Of Translation Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Neuron Remodeling Sperm Chromatin Condensation Rhythmic Process Immune Response Positive Regulation Of Interleukin-12 Biosynthetic Process Reproductive Process Positive Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Regulation Of Interleukin-12 Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process MRNA Processing Inflammatory Response Cellular Copper Ion Homeostasis Positive Regulation Of Gene Expression Cell Differentiation Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Viral Genome Replication Copper Ion Homeostasis Suckling Behavior Neurogenesis Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Tagcloud ?		augment augments bait cbp coactivator coil coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks myc potentiate recruitment reveal screen stat stat1 stat2 stat5 stat5b stats yeast	990a als amyotrophic arg522arg brainstem causative degeneration expansion fatal frequencies fus genetically gly93cys hexanucleotide leu330leu massive motor pathogenic remaining representative silent slavic slovenia slovenian sod1 sporadic synonymous tardbp val14met
Tagcloud (Difference) ?		augment augments bait cbp coactivator coil coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks myc potentiate recruitment reveal screen stat stat1 stat2 stat5 stat5b stats yeast	990a als amyotrophic arg522arg brainstem causative degeneration expansion fatal frequencies fus genetically gly93cys hexanucleotide leu330leu massive motor pathogenic remaining representative silent slavic slovenia slovenian sod1 sporadic synonymous tardbp val14met
Tagcloud (Intersection) ?