PER2 and CRY2

Number of citations of the paper that reports this interaction (PMID 10428031)
262

Data Source:
BioGRID (two hybrid)
HPRD (in vivo)

		PER2	CRY2
Gene Name		period circadian clock 2	cryptochrome circadian clock 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Perinuclear Region Of Cytoplasm	Extracellular Region Nucleus Cytoplasm
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Binding Transcription Factor Activity Core Promoter Binding Transcription Corepressor Binding Transcription Coactivator Activity Signal Transducer Activity Protein Binding Kinase Binding Nuclear Hormone Receptor Binding Pre-mRNA Binding Histone Deacetylase Binding Ubiquitin Binding RNA Polymerase Binding Histone Methyltransferase Binding	Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Binding Transcription Factor Activity DNA Binding Damaged DNA Binding Single-stranded DNA Binding Deoxyribodipyrimidine Photo-lyase Activity DNA (6-4) Photolyase Activity Protein Binding Blue Light Photoreceptor Activity Phosphatase Binding Ubiquitin Binding FAD Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Ischemia Glycogen Biosynthetic Process Gluconeogenesis Transcription, DNA-templated Fatty Acid Metabolic Process Signal Transduction Circadian Rhythm Regulation Of Vasoconstriction Lactate Biosynthetic Process Negative Regulation Of Protein Ubiquitination Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Negative Regulation Of Transcription, DNA-templated Regulation Of Neurogenesis Regulation Of Insulin Secretion White Fat Cell Differentiation Regulation Of Cell Cycle Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Negative Regulation Of DNA-templated Transcription, Termination Negative Regulation Of Fat Cell Proliferation Histone H3 Deacetylation Circadian Regulation Of Translation Negative Regulation Of Transcription Regulatory Region DNA Binding	Negative Regulation Of Transcription From RNA Polymerase II Promoter Photoreactive Repair Transcription, DNA-templated Circadian Rhythm Blue Light Signaling Pathway Protein-chromophore Linkage Negative Regulation Of Phosphoprotein Phosphatase Activity Circadian Regulation Of Gene Expression Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Transcription, DNA-templated Regulation Of Sodium-dependent Phosphate Transport Negative Regulation Of Glucocorticoid Receptor Signaling Pathway
Pathways		BMAL1:CLOCK,NPAS2 activates circadian gene expression	BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs
Diseases
GWAS			Fasting glucose-related traits ( 20081858) Fasting glucose-related traits (interaction with BMI) ( 22581228) Visceral fat ( 22589738)
Protein-Protein Interactions		9 interactors: CRY1 CRY2 CSNK1D CSNK1E PER1 PER3 TIMELESS TP53 TPT1	11 interactors: ATXN1 BRCA1 CTBP1 MTUS2 PDE9A PER1 PER2 PER3 PPP5C TIMELESS TTC1
Entrez ID		8864	1408
HPRD ID		04575	07226
Ensembl ID		ENSG00000132326	ENSG00000121671
Uniprot IDs		O15055	B4DZD6 Q49AN0
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Circadian Rhythm Circadian Rhythm Rhythmic Process Circadian Regulation Of Gene Expression Entrainment Of Circadian Clock By Photoperiod Photoperiodism Entrainment Of Circadian Clock Negative Regulation Of Glucocorticoid Receptor Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Blue Light Signaling Pathway Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Response To Blue Light Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Response To Light Stimulus Cellular Response To Light Stimulus Cellular Response To DNA Damage Stimulus Regulation Of Signal Transduction Protein-chromophore Linkage Response To Radiation Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Cellular Response To Radiation Regulation Of Signaling Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Abiotic Stimulus Negative Regulation Of Circadian Rhythm Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process DNA Repair Transcription, DNA-templated Nitrogen Compound Metabolic Process RNA Biosynthetic Process Response To Stimulus Mitotic Cell Cycle Process Cell Cycle Phase Transition Mitotic Cell Cycle Cellular Response To Stress Cellular Response To Stimulus Response To External Stimulus Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process	Negative Regulation Of Transcription, DNA-templated Regulation Of Circadian Rhythm Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Circadian Rhythm Circadian Regulation Of Translation Regulation Of Transcription From RNA Polymerase II Promoter Circadian Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Rhythmic Process Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process RNA Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Histone H4 Acetylation Negative Regulation Of Histone Acetylation White Fat Cell Differentiation Negative Regulation Of Peptidyl-lysine Acetylation Negative Regulation Of Protein Acetylation Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Histone H3 Deacetylation Biosynthetic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Regulation Of Histone Acetylation Nitrogen Compound Metabolic Process Histone Deacetylation Protein Deacetylation Positive Regulation Of Histone Modification Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Negative Regulation Of DNA-templated Transcription, Termination Negative Regulation Of Transcription From RNA Polymerase II Promoter By Histone Modification Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Histone Modification Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Chromosome Organization Organelle Organization Response To Radiation Response To Abiotic Stimulus Negative Regulation Of Fat Cell Proliferation
Tagcloud ?		aperiodic arnt brighton brosens chan circadian clock conceptus congruently cryptochrome decidual decidualizing disorganized grossly hescs kaput lacey lucas midluteal miscarriages moore muter oscillations predicated preponderance quenby silences synchronizes uncoupling	aiming arntl2 circadian clinicopathological clock clockwork coefficients compromised coordinated disturbances fdr functionality indicative metastasizing mfs neoadjuvant nfil3 npas2 pairwise per1 per2 per3 progressed rhythm rorc stratification stronger systematically weaker
Tagcloud (Difference) ?		aperiodic arnt brighton brosens chan conceptus congruently cryptochrome decidual decidualizing disorganized grossly hescs kaput lacey lucas midluteal miscarriages moore muter oscillations predicated preponderance quenby silences synchronizes uncoupling	aiming arntl2 clinicopathological clockwork coefficients compromised coordinated disturbances fdr functionality indicative metastasizing mfs neoadjuvant nfil3 npas2 pairwise per1 per3 progressed rhythm rorc stratification stronger systematically weaker
Tagcloud (Intersection) ?		circadian clock per2