CRY2 and TTC1

Number of citations of the paper that reports this interaction (PMID 9383998)
24

Data Source:
BioGRID (two hybrid)

		CRY2	TTC1
Gene Name		cryptochrome circadian clock 2	tetratricopeptide repeat domain 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm	Cytoplasm Peroxisomal Membrane
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Binding Transcription Factor Activity DNA Binding Damaged DNA Binding Single-stranded DNA Binding Deoxyribodipyrimidine Photo-lyase Activity DNA (6-4) Photolyase Activity Protein Binding Blue Light Photoreceptor Activity Phosphatase Binding Ubiquitin Binding FAD Binding	Protein Binding Unfolded Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Photoreactive Repair Transcription, DNA-templated Circadian Rhythm Blue Light Signaling Pathway Protein-chromophore Linkage Negative Regulation Of Phosphoprotein Phosphatase Activity Circadian Regulation Of Gene Expression Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Transcription, DNA-templated Regulation Of Sodium-dependent Phosphate Transport Negative Regulation Of Glucocorticoid Receptor Signaling Pathway	Protein Folding
Pathways		BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs
Diseases
GWAS		Fasting glucose-related traits ( 20081858) Fasting glucose-related traits (interaction with BMI) ( 22581228) Visceral fat ( 22589738)
Protein-Protein Interactions		11 interactors: ATXN1 BRCA1 CTBP1 MTUS2 PDE9A PER1 PER2 PER3 PPP5C TIMELESS TTC1	17 interactors: ACY1 CRY2 GNA15 GNAI2 GNAQ GNAS HRAS HSPA1A HSPA4 HSPA8 NDE1 RNF41 SH3BP4 SOX5 SPP1 SREBF2 TGFBR1
Entrez ID		1408	7265
HPRD ID		07226	11881
Ensembl ID		ENSG00000121671	ENSG00000113312
Uniprot IDs		B4DZD6 Q49AN0	Q99614
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Regulation Of Circadian Rhythm Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Circadian Rhythm Circadian Regulation Of Translation Regulation Of Transcription From RNA Polymerase II Promoter Circadian Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Rhythmic Process Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process RNA Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Histone H4 Acetylation Negative Regulation Of Histone Acetylation White Fat Cell Differentiation Negative Regulation Of Peptidyl-lysine Acetylation Negative Regulation Of Protein Acetylation Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Histone H3 Deacetylation Biosynthetic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Regulation Of Histone Acetylation Nitrogen Compound Metabolic Process Histone Deacetylation Protein Deacetylation Positive Regulation Of Histone Modification Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Negative Regulation Of DNA-templated Transcription, Termination Negative Regulation Of Transcription From RNA Polymerase II Promoter By Histone Modification Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Histone Modification Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Chromosome Organization Organelle Organization Response To Radiation Response To Abiotic Stimulus Negative Regulation Of Fat Cell Proliferation	Cellular Response To Stimulus Response To Stimulus Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Response To Organic Substance Wound Healing Positive Regulation Of Metabolic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Response To Stress Regulation Of Cell Differentiation Response To Wounding Blood Coagulation Platelet Activation Hemostasis Activation Of MAPKK Activity Phospholipase C-activating Dopamine Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Growth Regulation Of Phosphorus Metabolic Process Regulation Of Body Fluid Levels G-protein Coupled Acetylcholine Receptor Signaling Pathway Regulation Of Growth Generation Of Neurons Neurogenesis Negative Regulation Of Cell Proliferation Cell Activation Regulation Of Cell Growth Protein Refolding Regulation Of Catalytic Activity Response To Unfolded Protein Post-embryonic Development Locomotion Negative Regulation Of Catalytic Activity Regulation Of Metabolic Process Negative Regulation Of Cell Growth Regulation Of Cellular Response To Heat Regulation Of Myeloid Cell Differentiation Negative Regulation Of GTPase Activity Regulation Of Signal Transduction Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Proliferation Positive Regulation Of Catalytic Activity Skeletal System Development Regulation Of Gene Expression Nervous System Development Activation Of Phospholipase C Activity Regulation Of Signaling Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Positive Regulation Of Phospholipase C Activity
Tagcloud ?		aiming arntl2 circadian clinicopathological clock clockwork coefficients compromised coordinated disturbances fdr functionality indicative metastasizing mfs neoadjuvant nfil3 npas2 pairwise per1 per2 per3 progressed rhythm rorc stratification stronger systematically weaker
Tagcloud (Difference) ?		aiming arntl2 circadian clinicopathological clock clockwork coefficients compromised coordinated disturbances fdr functionality indicative metastasizing mfs neoadjuvant nfil3 npas2 pairwise per1 per2 per3 progressed rhythm rorc stratification stronger systematically weaker
Tagcloud (Intersection) ?