PER2 and CSNK1D

Number of citations of the paper that reports this interaction (PMID 15800623)
144

Data Source:
HPRD (in vitro)

		PER2	CSNK1D
Gene Name		period circadian clock 2	casein kinase 1, delta
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Perinuclear Region Of Cytoplasm	Nucleus Golgi Apparatus Centrosome Spindle Cytosol Spindle Microtubule Plasma Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Binding Transcription Factor Activity Core Promoter Binding Transcription Corepressor Binding Transcription Coactivator Activity Signal Transducer Activity Protein Binding Kinase Binding Nuclear Hormone Receptor Binding Pre-mRNA Binding Histone Deacetylase Binding Ubiquitin Binding RNA Polymerase Binding Histone Methyltransferase Binding	Glycoprotein Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Peptide Binding Tau-protein Kinase Activity Phosphoprotein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Ischemia Glycogen Biosynthetic Process Gluconeogenesis Transcription, DNA-templated Fatty Acid Metabolic Process Signal Transduction Circadian Rhythm Regulation Of Vasoconstriction Lactate Biosynthetic Process Negative Regulation Of Protein Ubiquitination Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Negative Regulation Of Transcription, DNA-templated Regulation Of Neurogenesis Regulation Of Insulin Secretion White Fat Cell Differentiation Regulation Of Cell Cycle Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Negative Regulation Of DNA-templated Transcription, Termination Negative Regulation Of Fat Cell Proliferation Histone H3 Deacetylation Circadian Regulation Of Translation Negative Regulation Of Transcription Regulatory Region DNA Binding	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Positive Regulation Of Protein Phosphorylation DNA Repair Protein Phosphorylation Endocytosis Organelle Organization Signal Transduction Regulation Of Cell Shape Wnt Signaling Pathway Peptidyl-serine Phosphorylation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Spindle Assembly Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		BMAL1:CLOCK,NPAS2 activates circadian gene expression	Organelle biogenesis and maintenance Assembly of the primary cilium G2/M Transition Anchoring of the basal body to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes Centrosome maturation Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: CRY1 CRY2 CSNK1D CSNK1E PER1 PER3 TIMELESS TP53 TPT1	27 interactors: AKAP9 APP ARFGAP1 ATM BACE1 BRCA1 CDK5 CTNNB1 DVL1 DVL3 GJA1 HN1L KDR LURAP1 MAPT PER1 PER2 PER3 PPP1R14A PSEN2 SMAD2 SMAD3 SNAPIN SNCA TP53 TRIM9 YWHAZ
Entrez ID		8864	1453
HPRD ID		04575	02920
Ensembl ID		ENSG00000132326	ENSG00000141551
Uniprot IDs		O15055	H7BYT1 P48730
PDB IDs			3UYS 3UYT 3UZP 4HGT 4HNF 4KB8 4KBA 4KBC 4KBK
Enriched GO Terms of Interacting Partners?		Regulation Of Circadian Rhythm Circadian Rhythm Rhythmic Process Circadian Regulation Of Gene Expression Entrainment Of Circadian Clock By Photoperiod Photoperiodism Entrainment Of Circadian Clock Negative Regulation Of Glucocorticoid Receptor Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Blue Light Signaling Pathway Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Response To Blue Light Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Response To Light Stimulus Cellular Response To Light Stimulus Cellular Response To DNA Damage Stimulus Regulation Of Signal Transduction Protein-chromophore Linkage Response To Radiation Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Cellular Response To Radiation Regulation Of Signaling Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Abiotic Stimulus Negative Regulation Of Circadian Rhythm Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process DNA Repair Transcription, DNA-templated Nitrogen Compound Metabolic Process RNA Biosynthetic Process Response To Stimulus Mitotic Cell Cycle Process Cell Cycle Phase Transition Mitotic Cell Cycle Cellular Response To Stress Cellular Response To Stimulus Response To External Stimulus Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process	Regulation Of Cellular Component Organization Regulation Of Protein Metabolic Process Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Signaling Positive Regulation Of Protein Metabolic Process Apoptotic Process Cell Communication Programmed Cell Death Regulation Of Binding Cell Death Death Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Embryo Development Establishment Of Organelle Localization Positive Regulation Of Signal Transduction Regulation Of Cellular Localization Regulation Of Protein Phosphorylation Negative Regulation Of Cellular Protein Metabolic Process Organelle Localization Regulation Of Cell Development Cell Development Negative Regulation Of Protein Metabolic Process Developmental Growth Cell-cell Signaling Regulation Of Organelle Organization Synapse Organization Regulation Of Cell Differentiation Embryonic Organ Development Growth Positive Regulation Of Metabolic Process Secretion By Cell Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Establishment Of Vesicle Localization Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Positive Regulation Of Cellular Metabolic Process Vesicle Localization Epithelium Development Response To Abiotic Stimulus Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Synaptic Vesicle Transport Organelle Organization Negative Regulation Of Nucleic Acid-templated Transcription
Tagcloud ?		aperiodic arnt brighton brosens chan circadian clock conceptus congruently cryptochrome decidual decidualizing disorganized grossly hescs kaput lacey lucas midluteal miscarriages moore muter oscillations predicated preponderance quenby silences synchronizes uncoupling
Tagcloud (Difference) ?		aperiodic arnt brighton brosens chan circadian clock conceptus congruently cryptochrome decidual decidualizing disorganized grossly hescs kaput lacey lucas midluteal miscarriages moore muter oscillations predicated preponderance quenby silences synchronizes uncoupling
Tagcloud (Intersection) ?