RLIM and LHX1

Number of citations of the paper that reports this interaction (PMID 11882901)
41

Data Source:
HPRD (in vitro)

		RLIM	LHX1
Gene Name		ring finger protein, LIM domain interacting	LIM homeobox 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Transcriptional Repressor Complex	Nucleus Protein Complex
	Molecular Function	Transcription Corepressor Activity Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity	Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Zinc Ion Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Random Inactivation Of X Chromosome	Urogenital System Development Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Gastrulation With Mouth Forming Second Ectoderm Formation Endoderm Formation Kidney Development Transcription From RNA Polymerase II Promoter Cell-cell Signaling Pattern Specification Process Nervous System Development Motor Neuron Axon Guidance Anatomical Structure Morphogenesis Post-embryonic Development Embryonic Pattern Specification Organ Morphogenesis Anterior/posterior Axis Specification Anterior/posterior Pattern Specification Dorsal/ventral Pattern Formation Regulation Of Gene Expression Retina Layer Formation Ventral Spinal Cord Development Spinal Cord Association Neuron Differentiation Telencephalon Development Cerebellum Development Cerebellar Purkinje Cell Differentiation Forebrain Regionalization Cerebellar Purkinje Cell-granule Cell Precursor Cell Signaling Involved In Regulation Of Granule Cell Precursor Cell Proliferation Somite Rostral/caudal Axis Specification Metanephric Part Of Ureteric Bud Development Oviduct Epithelium Development Uterine Epithelium Development Nephric Duct Elongation Horizontal Cell Localization Positive Regulation Of Embryonic Development Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Anatomical Structure Formation Involved In Morphogenesis Embryonic Viscerocranium Morphogenesis Pronephros Development Embryonic Retina Morphogenesis In Camera-type Eye Uterus Development Oviduct Development Cervix Development Vagina Development Head Development Epithelium Development Paramesonephric Duct Development Comma-shaped Body Morphogenesis S-shaped Body Morphogenesis Renal Vesicle Morphogenesis Mesonephric Duct Development Nephric Duct Morphogenesis Metanephric Glomerulus Development Metanephric Comma-shaped Body Morphogenesis Metanephric Renal Vesicle Morphogenesis Metanephric S-shaped Body Morphogenesis Primitive Streak Formation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Lateral Motor Column Neuron Migration Positive Regulation Of Gastrulation Positive Regulation Of Anterior Head Development Positive Regulation Of Nephron Tubule Epithelial Cell Differentiation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		27 interactors: ESR1 ISL1 LDB1 LDB2 LHX1 LHX2 LHX3 LIMK1 LMO2 LNX2 PDLIM1 REXO1 RPS14 SIN3A SMURF2 SNX17 SS18L1 STAT6 STMN1 TERF1 TNFAIP3 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2	5 interactors: FOXA2 ISL1 LHX3 OTX2 RLIM
Entrez ID		51132	3975
HPRD ID		02304	09067
Ensembl ID		ENSG00000131263	ENSG00000132130
Uniprot IDs		Q9NVW2	P48742 Q58F18
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Protein Polyubiquitination Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Macromolecule Biosynthetic Process Transcription, DNA-templated Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Activation Of Innate Immune Response Negative Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Innate Immune Response RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Protein K11-linked Ubiquitination Negative Regulation Of RNA Biosynthetic Process Cellular Response To Organic Substance Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Chromosome Organization Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Response To Stimulus Positive Regulation Of Immune Response Gene Expression Regulation Of Cell Cycle Phase Transition Negative Regulation Of Protein Ubiquitination Regulation Of Immune System Process Regulation Of Innate Immune Response System Development Mitotic Spindle Assembly Checkpoint	Neuron Fate Commitment Cell Fate Specification Neuron Fate Specification Cell Fate Commitment Diencephalon Development Pattern Specification Process Positive Regulation Of Gastrulation Dorsal/ventral Pattern Formation Primitive Streak Formation Regulation Of Transcription From RNA Polymerase II Promoter Somite Rostral/caudal Axis Specification Spinal Cord Motor Neuron Cell Fate Specification Brain Development Head Development Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Central Nervous System Development Organ Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Embryonic Development Regulation Of Gastrulation Neuron Differentiation Spinal Cord Motor Neuron Differentiation Axon Guidance Cell Fate Determination Embryonic Axis Specification Positive Regulation Of Transcription, DNA-templated RNA Metabolic Process Pituitary Gland Development Gastrulation With Mouth Forming Second Ventral Spinal Cord Development Forebrain Development Gene Expression Cell Differentiation In Spinal Cord Positive Regulation Of Macromolecule Biosynthetic Process Anterior/posterior Axis Specification Cellular Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Generation Of Neurons Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Axonogenesis Neurogenesis Somitogenesis Embryonic Pattern Specification Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Regulation Of Smoothened Signaling Pathway
Tagcloud ?		activators acts clim coactivator deacetylase embryonic encoded enlarge exerts hdac homeodomain inactivation inducer interacts interfering p53 physically playing prevents recruiting repressed repression repressor s1 s4 sin3a sp1 tried	activin atp1b1 belongs bip caps elusive folding grp78 homeobox hspa5 hspa5mo knock lim malformation morphants morpholino mos multifunctional oligonucleotides participates pax2 pronephric pronephros rescued residing serves specification unfolded xenopus
Tagcloud (Difference) ?		activators acts clim coactivator deacetylase embryonic encoded enlarge exerts hdac homeodomain inactivation inducer interacts interfering p53 physically playing prevents recruiting repressed repression repressor s1 s4 sin3a sp1 tried	activin atp1b1 belongs bip caps elusive folding grp78 homeobox hspa5 hspa5mo knock malformation morphants morpholino mos multifunctional oligonucleotides participates pax2 pronephric pronephros rescued residing serves specification unfolded xenopus
Tagcloud (Intersection) ?		lim