EIF3G and EIF3H

Number of citations of the paper that reports this interaction (PMID 19615732)
279

Data Source:
BioGRID (affinity chromatography technology, biochemical)
HPRD (in vivo, in vitro)

		EIF3G	EIF3H
Gene Name		eukaryotic translation initiation factor 3, subunit G	eukaryotic translation initiation factor 3, subunit H
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Perinuclear Region Of Cytoplasm	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Extracellular Vesicular Exosome Eukaryotic Translation Initiation Factor 3 Complex, EIF3m
	Molecular Function	Nucleotide Binding Translation Initiation Factor Activity Protein Binding Poly(A) RNA Binding	Translation Initiation Factor Activity Protein Binding Poly(A) RNA Binding
	Biological Process	Formation Of Translation Preinitiation Complex Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process	Formation Of Translation Preinitiation Complex Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process
Pathways		Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression	Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression
Drugs
Diseases
GWAS			Colorectal cancer ( 18372905 21761138) Corneal curvature ( 22969067)
Protein-Protein Interactions		22 interactors: ACD AIFM1 APP EIF3A EIF3B EIF3C EIF3D EIF3H EIF3K EIF5 EPB41 FAM9B GADD45G GOLGA2 MPHOSPH6 MPP6 PIN1 PKN2 POT1 SMN1 SNCA TK1	8 interactors: ABI2 ABI3 CCDC85B DISC1 EIF3G EIF3K NCK2 SORBS3
Entrez ID		8666	8667
HPRD ID		04886	04885
Ensembl ID		ENSG00000130811
Uniprot IDs		O75821	B3KS98 O15372 Q6IB98
PDB IDs		2CQ0
Enriched GO Terms of Interacting Partners?		Formation Of Translation Preinitiation Complex Regulation Of Translational Initiation Ribonucleoprotein Complex Biogenesis Cellular Component Assembly Regulation Of Translation Posttranscriptional Regulation Of Gene Expression Ribonucleoprotein Complex Assembly Translational Initiation Regulation Of Cellular Protein Metabolic Process Cellular Macromolecular Complex Assembly Regulation Of Protein Metabolic Process Formation Of Cytoplasmic Translation Initiation Complex Translation Telomere Assembly Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Capping Positive Regulation Of Telomerase Activity Cytoplasmic Translational Initiation Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Cellular Metabolic Process Cytoplasmic Translation Negative Regulation Of Chromosome Organization Regulation Of Binding Regulation Of Telomerase Activity Positive Regulation Of Transferase Activity Maturation Of 5.8S RRNA Regulation Of Telomere Maintenance Positive Regulation Of DNA Biosynthetic Process Regulation Of Metabolic Process Response To Copper Ion Positive Regulation Of Catalytic Activity Gene Expression Regulation Of Protein Binding Positive Regulation Of Peptidase Activity Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Ribosome Biogenesis Protein Metabolic Process Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Biosynthetic Process Negative Regulation Of Thrombin Receptor Signaling Pathway Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Glutathione Peroxidase Activity Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Norepinephrine Uptake Positive Regulation Of Single-stranded Telomeric DNA Binding Positive Regulation Of DNA Strand Elongation	Formation Of Translation Preinitiation Complex Positive Regulation Of Cytoskeleton Organization Regulation Of Translation Actin Filament Organization Regulation Of Cellular Component Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Translational Initiation Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Cytoskeleton Organization Posttranscriptional Regulation Of Gene Expression Regulation Of Cytoskeleton Organization Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Actin Cytoskeleton Organization Movement Of Cell Or Subcellular Component Actin Filament-based Process Cellular Macromolecular Complex Assembly Ribonucleoprotein Complex Assembly Cell Migration Translational Initiation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cell Motility Regulation Of Organelle Organization Positive Regulation Of Actin Nucleation Regulation Of Protein Metabolic Process Regulation Of Cellular Process Positive Regulation Of Cellular Component Biogenesis Signal Complex Assembly Ribonucleoprotein Complex Biogenesis Mitochondrial Calcium Ion Homeostasis Locomotion Positive Regulation Of Signal Transduction Rac Protein Signal Transduction Regulation Of Synapse Maturation Regulation Of Arp2/3 Complex-mediated Actin Nucleation TOR Signaling Regulation Of Actin Nucleation
Tagcloud ?		bimolecular c2hc complementation defense eifs enhancing eukaryotic finger fragment hybrid impair interfere machinery motif nia papaya preinitiation pro protoplasts prsv residues ringspot sos translation translational validated yeast zinc	1alpha angiogenesis approved cutaneous deacetylase dramatically eif3g fda hdac hdac9 hdaci hdacis hepatocellular hif highlighted hsp70 hsp90 hydroxamic hydroxylases master modulating prolyl representing romidepsin saha silencing suberoylanilide translation vorinostat
Tagcloud (Difference) ?		bimolecular c2hc complementation defense eifs enhancing eukaryotic finger fragment hybrid impair interfere machinery motif nia papaya preinitiation pro protoplasts prsv residues ringspot sos translational validated yeast zinc	1alpha angiogenesis approved cutaneous deacetylase dramatically fda hdac hdac9 hdaci hdacis hepatocellular hif highlighted hsp70 hsp90 hydroxamic hydroxylases master modulating prolyl representing romidepsin saha silencing suberoylanilide vorinostat
Tagcloud (Intersection) ?		eif3g translation