EIF3G

Gene Name		eukaryotic translation initiation factor 3, subunit G
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Translation Initiation Factor Activity Protein Binding Poly(A) RNA Binding
	Biological Process	Formation Of Translation Preinitiation Complex Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process
Pathways		Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression
Drugs
Diseases
GWAS
Protein-protein Interactions		22 interactors: ACD AIFM1 APP EIF3A EIF3B EIF3C EIF3D EIF3H EIF3K EIF5 EPB41 FAM9B GADD45G GOLGA2 MPHOSPH6 MPP6 PIN1 PKN2 POT1 SMN1 SNCA TK1
Entrez ID		8666
HPRD ID		04886
Ensembl ID		ENSG00000130811
Uniprot IDs		O75821
PDB IDs		2CQ0
Enriched GO Terms of Interacting Partners?		Formation Of Translation Preinitiation Complex Regulation Of Translational Initiation Ribonucleoprotein Complex Biogenesis Cellular Component Assembly Regulation Of Translation Posttranscriptional Regulation Of Gene Expression Ribonucleoprotein Complex Assembly Translational Initiation Regulation Of Cellular Protein Metabolic Process Cellular Macromolecular Complex Assembly Regulation Of Protein Metabolic Process Formation Of Cytoplasmic Translation Initiation Complex Translation Telomere Assembly Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Capping Positive Regulation Of Telomerase Activity Cytoplasmic Translational Initiation Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Cellular Metabolic Process Cytoplasmic Translation Negative Regulation Of Chromosome Organization Regulation Of Binding Regulation Of Telomerase Activity Positive Regulation Of Transferase Activity Maturation Of 5.8S RRNA Regulation Of Telomere Maintenance Positive Regulation Of DNA Biosynthetic Process Regulation Of Metabolic Process Response To Copper Ion Positive Regulation Of Catalytic Activity Gene Expression Regulation Of Protein Binding Positive Regulation Of Peptidase Activity Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Ribosome Biogenesis Protein Metabolic Process Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Biosynthetic Process Negative Regulation Of Thrombin Receptor Signaling Pathway Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Glutathione Peroxidase Activity Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Norepinephrine Uptake Positive Regulation Of Single-stranded Telomeric DNA Binding Positive Regulation Of DNA Strand Elongation
Tagcloud ?		bimolecular c2hc complementation defense eifs enhancing eukaryotic finger fragment hybrid impair interfere machinery motif nia papaya preinitiation pro protoplasts prsv residues ringspot sos translation translational validated yeast zinc