EIF3H and EIF3K

Number of citations of the paper that reports this interaction (PMID 14519125)
13

Data Source:
HPRD (in vitro)

		EIF3H	EIF3K
Gene Name		eukaryotic translation initiation factor 3, subunit H	eukaryotic translation initiation factor 3, subunit K
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Extracellular Vesicular Exosome Eukaryotic Translation Initiation Factor 3 Complex, EIF3m	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Extracellular Vesicular Exosome
	Molecular Function	Translation Initiation Factor Activity Protein Binding Poly(A) RNA Binding	Translation Initiation Factor Activity Protein Binding Ribosome Binding
	Biological Process	Formation Of Translation Preinitiation Complex Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process	Formation Of Translation Preinitiation Complex Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process
Pathways		Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression	Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression
Drugs
Diseases
GWAS		Colorectal cancer ( 18372905 21761138) Corneal curvature ( 22969067)
Protein-Protein Interactions		8 interactors: ABI2 ABI3 CCDC85B DISC1 EIF3G EIF3K NCK2 SORBS3	7 interactors: CCND3 EIF3C EIF3G EIF3H EIF3J EIF3L SPP1
Entrez ID		8667	27335
HPRD ID		04885	11740
Ensembl ID			ENSG00000178982
Uniprot IDs		B3KS98 O15372 Q6IB98	K7EK53 Q9UBQ5
PDB IDs			1RZ4
Enriched GO Terms of Interacting Partners?		Formation Of Translation Preinitiation Complex Positive Regulation Of Cytoskeleton Organization Regulation Of Translation Actin Filament Organization Regulation Of Cellular Component Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Translational Initiation Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Cytoskeleton Organization Posttranscriptional Regulation Of Gene Expression Regulation Of Cytoskeleton Organization Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Actin Cytoskeleton Organization Movement Of Cell Or Subcellular Component Actin Filament-based Process Cellular Macromolecular Complex Assembly Ribonucleoprotein Complex Assembly Cell Migration Translational Initiation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cell Motility Regulation Of Organelle Organization Positive Regulation Of Actin Nucleation Regulation Of Protein Metabolic Process Regulation Of Cellular Process Positive Regulation Of Cellular Component Biogenesis Signal Complex Assembly Ribonucleoprotein Complex Biogenesis Mitochondrial Calcium Ion Homeostasis Locomotion Positive Regulation Of Signal Transduction Rac Protein Signal Transduction Regulation Of Synapse Maturation Regulation Of Arp2/3 Complex-mediated Actin Nucleation TOR Signaling Regulation Of Actin Nucleation	Formation Of Translation Preinitiation Complex Regulation Of Translational Initiation Ribonucleoprotein Complex Assembly Translational Initiation Regulation Of Translation Ribonucleoprotein Complex Biogenesis Posttranscriptional Regulation Of Gene Expression Cellular Macromolecular Complex Assembly Translation Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Component Assembly Cellular Protein Metabolic Process Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Protein Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Collateral Sprouting Negative Regulation Of Axon Regeneration Cytoplasmic Translation Positive Regulation Of Bone Resorption Biosynthetic Process Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Axon Regeneration Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Cellular Process Positive Regulation Of Tissue Remodeling Decidualization Response To Vitamin D Regulation Of Bone Resorption Maternal Placenta Development Regulation Of Bone Remodeling
Tagcloud ?		1alpha angiogenesis approved cutaneous deacetylase dramatically eif3g fda hdac hdac9 hdaci hdacis hepatocellular hif highlighted hsp70 hsp90 hydroxamic hydroxylases master modulating prolyl representing romidepsin saha silencing suberoylanilide translation vorinostat	abundances bovine caprine carcasses carefully cd36 cln3 concentrate degradable erased genorm misinterpretation mrpl39 normalisation normalising partitioning ppia productions profitability rankings reference rplp0 ruminant ruminants sets sunflower tbp top2b uxt
Tagcloud (Difference) ?		1alpha angiogenesis approved cutaneous deacetylase dramatically eif3g fda hdac hdac9 hdaci hdacis hepatocellular hif highlighted hsp70 hsp90 hydroxamic hydroxylases master modulating prolyl representing romidepsin saha silencing suberoylanilide translation vorinostat	abundances bovine caprine carcasses carefully cd36 cln3 concentrate degradable erased genorm misinterpretation mrpl39 normalisation normalising partitioning ppia productions profitability rankings reference rplp0 ruminant ruminants sets sunflower tbp top2b uxt
Tagcloud (Intersection) ?