MET and RANBP10

Number of citations of the paper that reports this interaction (PMID 14684163)
12

Data Source:
HPRD (in vitro, in vivo)

		MET	RANBP10
Gene Name		MET proto-oncogene, receptor tyrosine kinase	RAN binding protein 10
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Basal Plasma Membrane Cell Surface Integral Component Of Membrane	Nucleus Cytosol Cytoplasmic Microtubule
	Molecular Function	Protein Tyrosine Kinase Activity Hepatocyte Growth Factor-activated Receptor Activity Protein Binding ATP Binding Protein Phosphatase Binding	Ran Guanyl-nucleotide Exchange Factor Activity Ran GTPase Binding Beta-tubulin Binding
	Biological Process	Activation Of MAPK Activity Endothelial Cell Morphogenesis Liver Development Placenta Development Signal Transduction Cell Surface Receptor Signaling Pathway Axon Guidance Brain Development Skeletal Muscle Tissue Development Cell Proliferation Positive Regulation Of Glucose Transport Muscle Cell Migration Myotube Differentiation Peptidyl-tyrosine Phosphorylation Adult Behavior Glucose Homeostasis Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Autophosphorylation Hepatocyte Growth Factor Receptor Signaling Pathway Branching Morphogenesis Of An Epithelial Tube Positive Chemotaxis Myoblast Proliferation Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Semaphorin-plexin Signaling Pathway Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Endothelial Cell Chemotaxis	Microtubule Cytoskeleton Organization Positive Regulation Of Ran GTPase Activity
Pathways		Axon guidance Semaphorin interactions Sema4D mediated inhibition of cell attachment and migration Sema4D in semaphorin signaling
Drugs		K-252a 1-(4-fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide N-({4-[(2-aminopyridin-4-yl)oxy]-3-fluorophenyl}carbamoyl)-2-(4-fluorophenyl)acetamide 2-(4-fluorophenyl)-N-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]carbamoyl}acetamide N-(3-chlorophenyl)-N-methyl-2-oxo-3-[(3,4,5-trimethyl-1H-pyrrol-2-yl)methyl]-2H-indole-5-sulfonamide 3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol 6-{[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine 1-[(2-NITROPHENYL)SULFONYL]-1H-PYRROLO[3,2-B]PYRIDINE-6-CARBOXAMIDE Cabozantinib
Diseases
GWAS		Multiple sclerosis (severity) ( 19010793)
Protein-Protein Interactions		37 interactors: BAG1 CASP3 CBL CNR1 CTNNB1 CTTN DAPK3 DCN DNAJA3 EGFR FAS GAB1 GLMN GRB2 HGF HGS INPP5D INPPL1 ITGB4 MUC20 PCBD2 PIK3R1 PLCG1 PLXNB1 PTPN11 PTPRB PTPRJ RANBP10 RANBP9 SHC1 SMC1A SNAPIN SNX2 SPSB1 SRC STAT3 VAV1	11 interactors: CACHD1 CNTNAP4 IGSF1 MEGF10 MET NEDD4 NEDD4L PRKCG RAN THSD7B TSEN2
Entrez ID		4233	57610
HPRD ID		01280	15207
Ensembl ID		ENSG00000105976	ENSG00000141084
Uniprot IDs		B4DLF5 P08581	B4DQH9 Q6VN20 R4GMX8
PDB IDs		1FYR 1R0P 1R1W 1SHY 1SSL 1UX3 2G15 2RFN 2RFS 2UZX 2UZY 2WD1 2WGJ 2WKM 3A4P 3BUX 3C1X 3CCN 3CD8 3CE3 3CTH 3CTJ 3DKC 3DKF 3DKG 3EFJ 3EFK 3F66 3F82 3I5N 3L8V 3LQ8 3Q6U 3Q6W 3QTI 3R7O 3RHK 3U6H 3U6I 3VW8 3ZXZ 3ZZE 4AOI 4AP7 4DEG 4DEH 4DEI 4EEV 4GG5 4GG7 4K3J
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Anatomical Structure Development Regulation Of Cell Activation Response To Growth Factor Developmental Process System Development Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Signaling Response To Fibroblast Growth Factor Regulation Of Signal Transduction Multicellular Organismal Development Positive Regulation Of Signal Transduction Regulation Of Immune System Process Signaling Cell Surface Receptor Signaling Pathway Signal Transduction Cell Communication Regulation Of Lymphocyte Activation Locomotion Movement Of Cell Or Subcellular Component Response To Wounding Regulation Of Phosphorylation Cell Differentiation Cell Motility Anatomical Structure Morphogenesis Neuron Differentiation Intracellular Signal Transduction Response To Organic Substance Neurogenesis Regulation Of Cell Adhesion Regulation Of Phosphorus Metabolic Process Cell Migration Regulation Of Intracellular Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Metabolic Process Fc Receptor Signaling Pathway Regulation Of Cell Death Generation Of Neurons Regulation Of T Cell Activation Regulation Of Protein Metabolic Process Blood Coagulation Hemostasis Response To Stimulus	Negative Regulation Of Sodium Ion Transport Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Potassium Ion Transmembrane Transport Protein Monoubiquitination Regulation Of Potassium Ion Transport Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Sodium Ion Transport Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Positive Regulation Of Mismatch Repair Skeletal Muscle Satellite Cell Proliferation Transmission Of Virus Development Involved In Symbiotic Interaction Regulation Of Protein Catabolic Process Negative Regulation Of Ion Transport Regulation Of Mismatch Repair Skeletal Muscle Cell Proliferation Skeletal Muscle Satellite Cell Activation Positive Regulation Of Caveolin-mediated Endocytosis Negative Regulation Of Cellular Response To Growth Factor Stimulus Ribosomal Small Subunit Export From Nucleus Viral Process Skeletal Muscle Tissue Development Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Skeletal Muscle Organ Development TRNA-type Intron Splice Site Recognition And Cleavage Protein Polyubiquitination Cell Activation Progesterone Receptor Signaling Pathway Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Myoblast Proliferation Regulation Of Caveolin-mediated Endocytosis Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Behavior Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Skeletal Muscle Satellite Cell Differentiation Negative Regulation Of Sodium Ion Transmembrane Transport Viral Life Cycle Positive Regulation Of Transport Intracellular Receptor Signaling Pathway Ribosomal Large Subunit Export From Nucleus Hepatocyte Growth Factor Receptor Signaling Pathway Recognition Of Apoptotic Cell Regulation Of Grooming Behavior Protein Autophosphorylation Negative Regulation Of Protein Localization To Cell Surface Negative Regulation Of Potassium Ion Transmembrane Transporter Activity
Tagcloud ?		basophil basophils c5a ccr2 ccr3 chains chemoattractant chemotactic continuous continuously cxcr1 cxcr2 eotaxin express fmlp formyl granulocyte hardly leu leukotrienes lt ltc4 macrophage mcp mcp1 mediate migratory phe unrelated weakly	actr1a backgrounds bbs2 bovines c2orf29 cnot7 cq cycling dnajc17 endometrium establishes friesian gapdh genorm holstein normalise normalised normfinder oestrus oxtr oxytocin ppia rps15a rps9 slc30a6 suitability suz12 uxt znf131
Tagcloud (Difference) ?		basophil basophils c5a ccr2 ccr3 chains chemoattractant chemotactic continuous continuously cxcr1 cxcr2 eotaxin express fmlp formyl granulocyte hardly leu leukotrienes lt ltc4 macrophage mcp mcp1 mediate migratory phe unrelated weakly	actr1a backgrounds bbs2 bovines c2orf29 cnot7 cq cycling dnajc17 endometrium establishes friesian gapdh genorm holstein normalise normalised normfinder oestrus oxtr oxytocin ppia rps15a rps9 slc30a6 suitability suz12 uxt znf131
Tagcloud (Intersection) ?