MET and PCBD2

Number of citations of the paper that reports this interaction (PMID 15546961)
3

Data Source:
HPRD (two hybrid)

		MET	PCBD2
Gene Name		MET proto-oncogene, receptor tyrosine kinase	pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2
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Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Basal Plasma Membrane Cell Surface Integral Component Of Membrane	Cellular_component Nucleus Mitochondrion
	Molecular Function	Protein Tyrosine Kinase Activity Hepatocyte Growth Factor-activated Receptor Activity Protein Binding ATP Binding Protein Phosphatase Binding	Phenylalanine 4-monooxygenase Activity Protein Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity
	Biological Process	Activation Of MAPK Activity Endothelial Cell Morphogenesis Liver Development Placenta Development Signal Transduction Cell Surface Receptor Signaling Pathway Axon Guidance Brain Development Skeletal Muscle Tissue Development Cell Proliferation Positive Regulation Of Glucose Transport Muscle Cell Migration Myotube Differentiation Peptidyl-tyrosine Phosphorylation Adult Behavior Glucose Homeostasis Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Autophosphorylation Hepatocyte Growth Factor Receptor Signaling Pathway Branching Morphogenesis Of An Epithelial Tube Positive Chemotaxis Myoblast Proliferation Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Semaphorin-plexin Signaling Pathway Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Endothelial Cell Chemotaxis	Tetrahydrobiopterin Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Protein Homotetramerization Protein Heterooligomerization Oxidation-reduction Process
Pathways		Axon guidance Semaphorin interactions Sema4D mediated inhibition of cell attachment and migration Sema4D in semaphorin signaling
Drugs		K-252a 1-(4-fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide N-({4-[(2-aminopyridin-4-yl)oxy]-3-fluorophenyl}carbamoyl)-2-(4-fluorophenyl)acetamide 2-(4-fluorophenyl)-N-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]carbamoyl}acetamide N-(3-chlorophenyl)-N-methyl-2-oxo-3-[(3,4,5-trimethyl-1H-pyrrol-2-yl)methyl]-2H-indole-5-sulfonamide 3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol 6-{[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine 1-[(2-NITROPHENYL)SULFONYL]-1H-PYRROLO[3,2-B]PYRIDINE-6-CARBOXAMIDE Cabozantinib
Diseases
GWAS		Multiple sclerosis (severity) ( 19010793)	Bulimia nervosa ( 23568457) Colorectal cancer ( 23263487) Height ( 18391951)
Protein-Protein Interactions		37 interactors: BAG1 CASP3 CBL CNR1 CTNNB1 CTTN DAPK3 DCN DNAJA3 EGFR FAS GAB1 GLMN GRB2 HGF HGS INPP5D INPPL1 ITGB4 MUC20 PCBD2 PIK3R1 PLCG1 PLXNB1 PTPN11 PTPRB PTPRJ RANBP10 RANBP9 SHC1 SMC1A SNAPIN SNX2 SPSB1 SRC STAT3 VAV1	31 interactors: AATF APP ASCC2 BRF1 C1D CDC5L CENPK CHAF1A GTF2E1 HES4 IRF2BP1 KCNIP3 MAGEA11 MED21 MED30 MED4 MED7 MET PBXIP1 PCBD1 PHF14 PML RUNX1T1 SNW1 SSX3 SSX5 STAT3 TAL2 TGIF2LY XBP1 ZZZ3
Entrez ID		4233	84105
HPRD ID		01280	17824
Ensembl ID		ENSG00000105976
Uniprot IDs		B4DLF5 P08581	Q9H0N5
PDB IDs		1FYR 1R0P 1R1W 1SHY 1SSL 1UX3 2G15 2RFN 2RFS 2UZX 2UZY 2WD1 2WGJ 2WKM 3A4P 3BUX 3C1X 3CCN 3CD8 3CE3 3CTH 3CTJ 3DKC 3DKF 3DKG 3EFJ 3EFK 3F66 3F82 3I5N 3L8V 3LQ8 3Q6U 3Q6W 3QTI 3R7O 3RHK 3U6H 3U6I 3VW8 3ZXZ 3ZZE 4AOI 4AP7 4DEG 4DEH 4DEI 4EEV 4GG5 4GG7 4K3J	4C45
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Anatomical Structure Development Regulation Of Cell Activation Response To Growth Factor Developmental Process System Development Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Signaling Response To Fibroblast Growth Factor Regulation Of Signal Transduction Multicellular Organismal Development Positive Regulation Of Signal Transduction Regulation Of Immune System Process Signaling Cell Surface Receptor Signaling Pathway Signal Transduction Cell Communication Regulation Of Lymphocyte Activation Locomotion Movement Of Cell Or Subcellular Component Response To Wounding Regulation Of Phosphorylation Cell Differentiation Cell Motility Anatomical Structure Morphogenesis Neuron Differentiation Intracellular Signal Transduction Response To Organic Substance Neurogenesis Regulation Of Cell Adhesion Regulation Of Phosphorus Metabolic Process Cell Migration Regulation Of Intracellular Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Metabolic Process Fc Receptor Signaling Pathway Regulation Of Cell Death Generation Of Neurons Regulation Of T Cell Activation Regulation Of Protein Metabolic Process Blood Coagulation Hemostasis Response To Stimulus	Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process RNA Biosynthetic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Cellular Process Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Positive Regulation Of Transcription, DNA-templated Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Apoptotic Process Negative Regulation Of Gene Expression Programmed Cell Death Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Cell Death Death Stem Cell Maintenance Transcription From RNA Polymerase II Promoter Cell Differentiation Positive Regulation Of Histone Modification Negative Regulation Of Cell Differentiation Stem Cell Development Developmental Process Positive Regulation Of Metabolic Process Regulation Of Cell Differentiation
Tagcloud ?		basophil basophils c5a ccr2 ccr3 chains chemoattractant chemotactic continuous continuously cxcr1 cxcr2 eotaxin express fmlp formyl granulocyte hardly leu leukotrienes lt ltc4 macrophage mcp mcp1 mediate migratory phe unrelated weakly
Tagcloud (Difference) ?		basophil basophils c5a ccr2 ccr3 chains chemoattractant chemotactic continuous continuously cxcr1 cxcr2 eotaxin express fmlp formyl granulocyte hardly leu leukotrienes lt ltc4 macrophage mcp mcp1 mediate migratory phe unrelated weakly
Tagcloud (Intersection) ?