DHX58 and EIF6

Number of citations of the paper that reports this interaction (PMID 21903422)
33

Data Source:
BioGRID (pull down)

		DHX58	EIF6
Gene Name		DEXH (Asp-Glu-X-His) box polypeptide 58	eukaryotic translation initiation factor 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Nucleus Lamin Filament Nucleoplasm Nucleolus Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Double-stranded RNA Binding Single-stranded RNA Binding Helicase Activity Protein Binding ATP Binding Zinc Ion Binding	Translation Initiation Factor Activity Protein Binding Ribosome Binding Ribosomal Large Subunit Binding
	Biological Process	Metabolic Process Response To Virus Viral Process Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Negative Regulation Of MDA-5 Signaling Pathway Negative Regulation Of RIG-I Signaling Pathway Innate Immune Response Regulation Of Innate Immune Response Negative Regulation Of Innate Immune Response Defense Response To Virus Positive Regulation Of MDA-5 Signaling Pathway Positive Regulation Of RIG-I Signaling Pathway	Ribosomal Subunit Export From Nucleus Translational Initiation Mature Ribosome Assembly Ribosomal Large Subunit Biogenesis
Pathways		RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Innate Immune System
Drugs
Diseases
GWAS			Height ( 18391951)
Protein-Protein Interactions		9 interactors: AGO2 AP2B1 APP DHX30 DICER1 EIF2AK2 EIF6 NKRF STAU2	38 interactors: ABCF1 ACAP3 ACTG1 AKT1S1 ALDH2 APP C4orf27 CLEC4G CRELD1 CSNK2B DHX58 EIF2AK2 ENOX1 FHL2 FUNDC2 GIT1 GNB2L1 HIP1 ITGB4 KIAA1377 LRIF1 MRPS31 OAS3 OFD1 OS9 PDHA1 PLK1 POLA2 PRKCB PSME1 RPL6 SEPT3 TK1 UPF3B USP33 WFS1 XRN2 ZBTB26
Entrez ID		79132	3692
HPRD ID		13115	04221
Ensembl ID		ENSG00000108771	ENSG00000242372
Uniprot IDs		Q96C10	P56537
PDB IDs		2RQA 2W4R 3EQT
Enriched GO Terms of Interacting Partners?		RNA Interference Pre-miRNA Processing Posttranscriptional Regulation Of Gene Expression Production Of MiRNAs Involved In Gene Silencing By MiRNA Ribonucleoprotein Complex Assembly Regulation Of Defense Response To Virus By Virus RNA Processing Gene Expression Gene Silencing By MiRNA Cellular Response To DsRNA Posttranscriptional Gene Silencing Regulation Of Translation Ribonucleoprotein Complex Biogenesis Gene Silencing By RNA Regulation Of Viral Genome Replication RNA Phosphodiester Bond Hydrolysis, Endonucleolytic Regulation Of Translational Initiation Response To DsRNA Regulation Of Epidermal Growth Factor Receptor Signaling Pathway RNA Metabolic Process Evasion Or Tolerance By Virus Of Host Immune Response Conversion Of Ds SiRNA To Ss SiRNA Involved In RNA Interference Hair Follicle Cell Proliferation Conversion Of Ds SiRNA To Ss SiRNA Regulation Of ERBB Signaling Pathway Regulation Of Defense Response To Virus Negative Regulation Of Translation Negative Regulation Of Cellular Metabolic Process Immune System Process Gene Silencing RNA Phosphodiester Bond Hydrolysis MRNA Cleavage Involved In Gene Silencing By MiRNA Regulation Of Enamel Mineralization Peripheral Nervous System Myelin Formation Synaptic Growth At Neuromuscular Junction Zygote Asymmetric Cell Division Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of Gene Expression Defense Response Negative Regulation Of Biosynthetic Process SiRNA Loading Onto RISC Involved In RNA Interference Targeting Of MRNA For Destruction Involved In RNA Interference Collateral Sprouting In Absence Of Injury Evasion Or Tolerance Of Host Defenses By Virus Notch Signaling Pathway Post-embryonic Development Cellular Macromolecular Complex Assembly Regulation Of Viral Process Neuron Projection Morphogenesis Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation	Positive Regulation Of Cellular Protein Metabolic Process Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Proteolysis Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Cell Cycle Cellular Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Protein Metabolic Process Regulation Of Proteolysis Regulation Of Translation Positive Regulation Of Peptidase Activity Regulation Of Protein Kinase Activity Mitotic Cell Cycle Regulation Of Signal Transduction Regulation Of Catalytic Activity Regulation Of Kinase Activity Regulation Of Metabolic Process Cell Projection Morphogenesis Cell Projection Organization Response To Stress Cell Part Morphogenesis Gene Expression Axon Guidance Regulation Of Signaling Positive Regulation Of Catalytic Activity Mitotic Cell Cycle Process Regulation Of Binding Negative Regulation Of Defense Response To Virus Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Hydrolase Activity Cell Cycle Process Regulation Of Cellular Ketone Metabolic Process Cell Morphogenesis Positive Regulation Of Metabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Phosphorylation Modification-dependent Protein Catabolic Process Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of Transferase Activity Axonogenesis Response To External Stimulus Positive Regulation Of Endopeptidase Activity Regulation Of Apoptotic Process Innate Immune Response
Tagcloud ?			40s 60s 80s associates biogenesis cerevisiae cessation depleted designated encodes imbalance lysates maps mer monosomes mr polyribosomes polysomal prevents ribosomal ribosomes saccharomyces stoichiometric subunits tif6 true ultimately xvi yeast
Tagcloud (Difference) ?			40s 60s 80s associates biogenesis cerevisiae cessation depleted designated encodes imbalance lysates maps mer monosomes mr polyribosomes polysomal prevents ribosomal ribosomes saccharomyces stoichiometric subunits tif6 true ultimately xvi yeast
Tagcloud (Intersection) ?