DHX58 and AP2B1

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DHX58	AP2B1
Gene Name		DEXH (Asp-Glu-X-His) box polypeptide 58	adaptor-related protein complex 2, beta 1 subunit
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Gene Ontology Annotations	Cellular Component	Cytoplasm	Cytosol Plasma Membrane Membrane AP-2 Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	DNA Binding Double-stranded RNA Binding Single-stranded RNA Binding Helicase Activity Protein Binding ATP Binding Zinc Ion Binding	Signal Sequence Binding Protein Binding Protein Transporter Activity Clathrin Binding Clathrin Adaptor Activity
	Biological Process	Metabolic Process Response To Virus Viral Process Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Negative Regulation Of MDA-5 Signaling Pathway Negative Regulation Of RIG-I Signaling Pathway Innate Immune Response Regulation Of Innate Immune Response Negative Regulation Of Innate Immune Response Defense Response To Virus Positive Regulation Of MDA-5 Signaling Pathway Positive Regulation Of RIG-I Signaling Pathway	Intracellular Protein Transport Epidermal Growth Factor Receptor Signaling Pathway Synaptic Transmission Axon Guidance Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Clathrin-mediated Endocytosis
Pathways		RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Innate Immune System	Retrograde neurotrophin signalling Axon guidance HIV Infection Nef Mediated CD8 Down-regulation L1CAM interactions Signaling by Wnt Signaling by EGFRvIII in Cancer Recycling pathway of L1 EPH-ephrin mediated repulsion of cells MHC class II antigen presentation EPH-Ephrin signaling Nef Mediated CD4 Down-regulation EGFR downregulation Signalling by NGF Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer beta-catenin independent WNT signaling Signaling by EGFR WNT5A-dependent internalization of FZD4 Signaling by EGFR in Cancer PCP/CE pathway Adaptive Immune System
Drugs
Diseases
GWAS			Mean platelet volume ( 22139419) Platelet counts ( 22139419)
Protein-Protein Interactions		9 interactors: AGO2 AP2B1 APP DHX30 DICER1 EIF2AK2 EIF6 NKRF STAU2	44 interactors: ACVR1 AFF4 AP1M1 AP1M2 AP2A2 AP2M1 AP2S1 APC ARRB1 ATM ATP6V1G1 BUB1 BUB1B CLINT1 CLTC DHX58 FAM46C GTF2I HIP1 ITSN1 KIAA0408 KPNA2 LDLRAP1 MEA1 MLH1 NECAP2 NEU4 NUP54 PIP5K1C POM121 RAPGEF3 RIBC2 SLC25A6 SMAD4 SMURF1 SNAP91 TERF2IP TGFBR1 TGFBR2 THAP1 TUBGCP4 TXN2 U2AF1 XRCC6BP1
Entrez ID		79132	163
HPRD ID		13115	03015
Ensembl ID		ENSG00000108771	ENSG00000006125
Uniprot IDs		Q96C10	K7EJT8 P63010 Q96EL6
PDB IDs		2RQA 2W4R 3EQT	1E42 2G30 2IV8 2IV9 2JKR 2JKT 2VGL 2XA7
Enriched GO Terms of Interacting Partners?		RNA Interference Pre-miRNA Processing Posttranscriptional Regulation Of Gene Expression Production Of MiRNAs Involved In Gene Silencing By MiRNA Ribonucleoprotein Complex Assembly Regulation Of Defense Response To Virus By Virus RNA Processing Gene Expression Gene Silencing By MiRNA Cellular Response To DsRNA Posttranscriptional Gene Silencing Regulation Of Translation Ribonucleoprotein Complex Biogenesis Gene Silencing By RNA Regulation Of Viral Genome Replication RNA Phosphodiester Bond Hydrolysis, Endonucleolytic Regulation Of Translational Initiation Response To DsRNA Regulation Of Epidermal Growth Factor Receptor Signaling Pathway RNA Metabolic Process Evasion Or Tolerance By Virus Of Host Immune Response Conversion Of Ds SiRNA To Ss SiRNA Involved In RNA Interference Hair Follicle Cell Proliferation Conversion Of Ds SiRNA To Ss SiRNA Regulation Of ERBB Signaling Pathway Regulation Of Defense Response To Virus Negative Regulation Of Translation Negative Regulation Of Cellular Metabolic Process Immune System Process Gene Silencing RNA Phosphodiester Bond Hydrolysis MRNA Cleavage Involved In Gene Silencing By MiRNA Regulation Of Enamel Mineralization Peripheral Nervous System Myelin Formation Synaptic Growth At Neuromuscular Junction Zygote Asymmetric Cell Division Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of Gene Expression Defense Response Negative Regulation Of Biosynthetic Process SiRNA Loading Onto RISC Involved In RNA Interference Targeting Of MRNA For Destruction Involved In RNA Interference Collateral Sprouting In Absence Of Injury Evasion Or Tolerance Of Host Defenses By Virus Notch Signaling Pathway Post-embryonic Development Cellular Macromolecular Complex Assembly Regulation Of Viral Process Neuron Projection Morphogenesis Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation	Protein Localization Regulation Of Defense Response To Virus By Virus Endocytosis Viral Process Cellular Localization Protein Transport Regulation Of Defense Response To Virus Vesicle-mediated Transport Establishment Of Protein Localization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Establishment Of Localization In Cell Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Intracellular Transport Clathrin Coat Assembly Membrane Organization Receptor-mediated Endocytosis Cellular Protein Localization Organelle Organization Regulation Of Cellular Component Organization Mitotic Spindle Assembly Checkpoint Negative Regulation Of Chromosome Organization Post-Golgi Vesicle-mediated Transport Cellular Response To Growth Factor Stimulus Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Apoptotic Process Clathrin-mediated Endocytosis Response To Growth Factor Negative Regulation Of Chromosome Segregation Programmed Cell Death Cell Cycle Process Cell Differentiation Regulation Of Mitotic Sister Chromatid Separation Cell Development Cell Death Death Regulation Of Signaling Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Regulation Of Chromosome Organization Regulation Of Signal Transduction Cellular Protein Complex Assembly Pathway-restricted SMAD Protein Phosphorylation Regulation Of Mitotic Metaphase/anaphase Transition Cellular Response To Organic Substance Negative Regulation Of Protein Catabolic Process Cell Activation Cell Cycle Mitotic Cell Cycle Process
Tagcloud ?			17q 17q12 aa552509 acly amplicon amplifications aoc3 copy custom est ests gains gastriccancer grb7 itga3 jup krt14 lhx1 mkp mln51 mln64 mprl45 pip5k2b q21 rpl27 tags top2a transcribed uncharacterized
Tagcloud (Difference) ?			17q 17q12 aa552509 acly amplicon amplifications aoc3 copy custom est ests gains gastriccancer grb7 itga3 jup krt14 lhx1 mkp mln51 mln64 mprl45 pip5k2b q21 rpl27 tags top2a transcribed uncharacterized
Tagcloud (Intersection) ?