IL1RN

Gene Name		interleukin 1 receptor antagonist
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Intracellular Cytoplasm Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Cytokine Activity Interleukin-1 Receptor Binding Interleukin-1, Type I Receptor Binding Interleukin-1, Type II Receptor Binding Interleukin-1 Receptor Antagonist Activity Interleukin-1 Type I Receptor Antagonist Activity Interleukin-1 Type II Receptor Antagonist Activity
	Biological Process	Fever Generation Negative Regulation Of Cytokine-mediated Signaling Pathway Chronic Inflammatory Response To Antigenic Stimulus Lipid Metabolic Process Acute-phase Response Immune Response Female Pregnancy Memory Negative Regulation Of Glutamate Secretion Response To Activity Sensory Perception Of Pain Carboxylic Acid Metabolic Process Insulin Secretion Negative Regulation Of Cell Migration Response To Lipopolysaccharide Negative Regulation Of Heterotypic Cell-cell Adhesion Response To Drug Response To Starvation Negative Regulation Of Apoptotic Process Positive Regulation Of JUN Kinase Activity Negative Regulation Of Membrane Potential Response To Glucocorticoid Response To Interleukin-1 Response To Interleukin-4 Cellular Response To Norepinephrine Stimulus Negative Regulation Of Interleukin-1-mediated Signaling Pathway
Pathways		Signaling by Interleukins Cytokine Signaling in Immune system Interleukin-1 signaling
Drugs
Diseases
GWAS		C-reactive protein ( 22939635) Obesity-related traits ( 23251661) Protein quantitative trait loci ( 18464913)
Protein-protein Interactions		4 interactors: IL1R1 IL1R2 POT1 TERF2IP
Entrez ID		3557
HPRD ID		00978
Ensembl ID		ENSG00000136689
Uniprot IDs		P18510
PDB IDs		1ILR 1ILT 1IRA 1IRP 1ITN 2IRT
Enriched GO Terms of Interacting Partners?		Telomere Capping Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance RNA-dependent DNA Replication Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Positive Regulation Of DNA Strand Elongation Negative Regulation Of DNA Recombination At Telomere Regulation Of Chromosome Organization Telomere Formation Via Telomerase Protection From Non-homologous End Joining At Telomere DNA Replication Positive Regulation Of Helicase Activity Negative Regulation Of Telomere Maintenance Via Telomerase Protein Localization To Chromosome, Telomeric Region Positive Regulation Of Telomerase Activity Telomere Assembly Positive Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomerase Activity Interleukin-1-mediated Signaling Pathway Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Cytokine-mediated Signaling Pathway Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Telomerase Activity Positive Regulation Of DNA Biosynthetic Process Cellular Response To Cytokine Stimulus Negative Regulation Of DNA Recombination Negative Regulation Of DNA Biosynthetic Process Regulation Of Double-strand Break Repair Protein Localization To Chromosome Response To Cytokine Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Cellular Response To Interleukin-1 Regulation Of Organelle Organization Chromosome Organization Regulation Of DNA Repair DNA Metabolic Process Positive Regulation Of DNA Replication Regulation Of DNA Recombination DNA Duplex Unwinding Response To Interleukin-1 DNA Geometric Change Immune Response Homeostatic Process
Tagcloud ?		asp299gly constant cosegregating differentially dysregulation endorsed explored fatigue genotyped investigating ischemic link nucleotide opposing polymorphisms poststroke psf remarkably rs4251961 rs4986790 rs4986791 snp snps stroke substitution substudy thr399ile tlr4 toll