IL1RN and POT1

Number of citations of the paper that reports this interaction (PMID 21044950)
9

Data Source:
BioGRID (two hybrid)

		IL1RN	POT1
Gene Name		interleukin 1 receptor antagonist	protection of telomeres 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Intracellular Cytoplasm Plasma Membrane Extracellular Vesicular Exosome	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Cytokine Activity Interleukin-1 Receptor Binding Interleukin-1, Type I Receptor Binding Interleukin-1, Type II Receptor Binding Interleukin-1 Receptor Antagonist Activity Interleukin-1 Type I Receptor Antagonist Activity Interleukin-1 Type II Receptor Antagonist Activity	Protein Binding Telomerase Inhibitor Activity DEAD/H-box RNA Helicase Binding Single-stranded Telomeric DNA Binding
	Biological Process	Fever Generation Negative Regulation Of Cytokine-mediated Signaling Pathway Chronic Inflammatory Response To Antigenic Stimulus Lipid Metabolic Process Acute-phase Response Immune Response Female Pregnancy Memory Negative Regulation Of Glutamate Secretion Response To Activity Sensory Perception Of Pain Carboxylic Acid Metabolic Process Insulin Secretion Negative Regulation Of Cell Migration Response To Lipopolysaccharide Negative Regulation Of Heterotypic Cell-cell Adhesion Response To Drug Response To Starvation Negative Regulation Of Apoptotic Process Positive Regulation Of JUN Kinase Activity Negative Regulation Of Membrane Potential Response To Glucocorticoid Response To Interleukin-1 Response To Interleukin-4 Cellular Response To Norepinephrine Stimulus Negative Regulation Of Interleukin-1-mediated Signaling Pathway	Telomere Maintenance Telomere Maintenance Via Telomerase Telomere Capping Telomere Formation Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase DNA Duplex Unwinding Positive Regulation Of Helicase Activity Positive Regulation Of Telomerase Activity Negative Regulation Of Telomerase Activity Positive Regulation Of DNA Strand Elongation
Pathways		Signaling by Interleukins Cytokine Signaling in Immune system Interleukin-1 signaling	Telomere Maintenance Packaging Of Telomere Ends DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Cellular Senescence Meiotic synapsis
Drugs
Diseases
GWAS		C-reactive protein ( 22939635) Obesity-related traits ( 23251661) Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		4 interactors: IL1R1 IL1R2 POT1 TERF2IP	166 interactors: ACD ACOT7 ACTB ACTN4 ACY1 AFAP1L2 AHCY AHNAK AIPL1 ALDH1A1 ALDH3A1 AMPD2 ANKMY2 ANXA2 ANXA4 APPL2 ARHGDIA ARID3B ARRB1 BAG3 BCAS2 BIN2 C15orf57 C2orf74 CALD1 CAMK1D CCDC9 CCM2 CFL1 CFL2 CKB CLIC3 CNST CORO1A COX6A2 CPNE3 CPPED1 CRK CRYGS CSNK2B CYP4F11 DBN1 DBNL DCX DDX19B DNPH1 DOK2 DPP3 DPYSL3 ECI1 EEF1D EIF3G EIF4B ENO2 ENSA EPB41L1 EVL FAM131B FBP1 FES GAMT GAPDH GAS2L1 GFPT2 GNMT GPA33 GPR52 GRN HAAO HLCS HMOX1 HNMT HOXA3 HSP90AB1 HSPA1A IFRD2 IL1RN ISYNA1 IVL KHDRBS1 KIAA1191 KRT18 LAMC3 LASP1 LDHA LDHB MADD MAGEA4 MAP4 MAP4K2 MAP7 MDM2 MICA MT1X MVK MVP MYO5C NAP1L1 NCDN NOL3 NUDC NUDCD2 NXNL1 PACSIN1 PACSIN2 PAGE2 PAGE5 PAK4 PALM PCP4 PDE1B PDLIM2 PEX5 PFKP PGLS PGM1 PGM2 PHYHD1 PHYKPL PIPOX PRMT7 PROSER2 RBKS RECQL4 RGS14 RIF1 RPAP1 RPSA RTN4 SARS SBDS SERTAD1 SH3BP1 SNCG STIP1 STUB1 SULT1B1 SULT1C2 SULT4A1 SYAP1 TAGLN TBCD TERF1 TERF2 TINF2 TMSB10 TMSB4Y TNKS TOMM34 TPI1 TPP1 TRIM16 TRIP10 TUBB2A TUBB4B TWF2 WIBG WIPI2 XAGE2 YWHAE YWHAG ZBED2 ZBTB49 ZFP36L1 ZNF32 ZNF790
Entrez ID		3557	25913
HPRD ID		00978	07572
Ensembl ID		ENSG00000136689	ENSG00000128513
Uniprot IDs		P18510	A8MTK3 Q5MJ33 Q9NUX5
PDB IDs		1ILR 1ILT 1IRA 1IRP 1ITN 2IRT	1XJV 3KJO 3KJP
Enriched GO Terms of Interacting Partners?		Telomere Capping Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance RNA-dependent DNA Replication Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Positive Regulation Of DNA Strand Elongation Negative Regulation Of DNA Recombination At Telomere Regulation Of Chromosome Organization Telomere Formation Via Telomerase Protection From Non-homologous End Joining At Telomere DNA Replication Positive Regulation Of Helicase Activity Negative Regulation Of Telomere Maintenance Via Telomerase Protein Localization To Chromosome, Telomeric Region Positive Regulation Of Telomerase Activity Telomere Assembly Positive Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomerase Activity Interleukin-1-mediated Signaling Pathway Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Cytokine-mediated Signaling Pathway Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Telomerase Activity Positive Regulation Of DNA Biosynthetic Process Cellular Response To Cytokine Stimulus Negative Regulation Of DNA Recombination Negative Regulation Of DNA Biosynthetic Process Regulation Of Double-strand Break Repair Protein Localization To Chromosome Response To Cytokine Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Cellular Response To Interleukin-1 Regulation Of Organelle Organization Chromosome Organization Regulation Of DNA Repair DNA Metabolic Process Positive Regulation Of DNA Replication Regulation Of DNA Recombination DNA Duplex Unwinding Response To Interleukin-1 DNA Geometric Change Immune Response Homeostatic Process	Protein Localization To Chromosome, Telomeric Region Regulation Of Telomere Maintenance Regulation Of Cellular Component Organization Regulation Of Telomere Maintenance Via Telomerase Organelle Organization Negative Regulation Of Telomere Maintenance Small Molecule Metabolic Process Cellular Component Assembly Regulation Of Organelle Organization Negative Regulation Of Telomere Maintenance Via Telomerase Cytoskeleton Organization Organic Acid Metabolic Process Response To Stimulus Catabolic Process Regulation Of Binding Cellular Process Carboxylic Acid Metabolic Process Cofactor Metabolic Process Protein Localization To Chromosome Cellular Response To Stimulus Actin Filament Organization Protection From Non-homologous End Joining At Telomere Response To Abiotic Stimulus Carbohydrate Catabolic Process Carbohydrate Biosynthetic Process Protein Localization Telomere Assembly Telomere Capping Positive Regulation Of Organelle Organization Nervous System Development Cellular Protein Localization Response To Stress Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Telomere Maintenance Cellular Metabolic Process Pyruvate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Regulation Of Cytoskeleton Organization Negative Regulation Of DNA Replication Response To External Stimulus Actin Cytoskeleton Organization Glycolytic Process Cellular Localization Regulation Of Protein Metabolic Process Gluconeogenesis Sequestering Of Actin Monomers Regulation Of Neuron Projection Development Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Developmental Process
Tagcloud ?		asp299gly constant cosegregating differentially dysregulation endorsed explored fatigue genotyped investigating ischemic link nucleotide opposing polymorphisms poststroke psf remarkably rs4251961 rs4986790 rs4986791 snp snps stroke substitution substudy thr399ile tlr4 toll	0mug celltiter chemosensitivity ddp downregulate fluorescein formerly gastroesophageal gc iodide isothiocyanate junction n87 nci oncological oxa oxaliplatin performing pip platinum propodium ptop telomere telomeric tint1 tpp1 trastuzumab trf2 trf2ip
Tagcloud (Difference) ?		asp299gly constant cosegregating differentially dysregulation endorsed explored fatigue genotyped investigating ischemic link nucleotide opposing polymorphisms poststroke psf remarkably rs4251961 rs4986790 rs4986791 snp snps stroke substitution substudy thr399ile tlr4 toll	0mug celltiter chemosensitivity ddp downregulate fluorescein formerly gastroesophageal gc iodide isothiocyanate junction n87 nci oncological oxa oxaliplatin performing pip platinum propodium ptop telomere telomeric tint1 tpp1 trastuzumab trf2 trf2ip
Tagcloud (Intersection) ?