ZNF140 and TRIM28

Number of citations of the paper that reports this interaction (PMID 8769649)
135

Data Source:
BioGRID (pull down)

		ZNF140	TRIM28
Gene Name		zinc finger protein 140	tripartite motif containing 28
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Nuclear Euchromatin Nuclear Heterochromatin RNA Polymerase II Transcription Factor Complex
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Metal Ion Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Kinase Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Binding Krueppel-associated Box Domain Binding Sequence-specific DNA Binding Poly(A) RNA Binding Chromo Shadow Domain Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription From RNA Polymerase II Promoter Epithelial To Mesenchymal Transition DNA Repair Transcription Initiation From RNA Polymerase II Promoter Embryo Implantation Gene Expression Protein Ubiquitination Protein Sumoylation Positive Regulation Of Transcription Factor Import Into Nucleus DNA Methylation Involved In Embryo Development Innate Immune Response Positive Regulation Of DNA Repair Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Protein Oligomerization Convergent Extension Involved In Axis Elongation Embryonic Placenta Morphogenesis Negative Regulation Of DNA Demethylation Negative Regulation Of Viral Release From Host Cell Regulation Of Genetic Imprinting
Pathways		Generic Transcription Pathway	Generic Transcription Pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		1 interactors: TRIM28	62 interactors: CBX1 CBX3 CBX5 CDC34 CDCA4 CEBPB CHAF1A CHD3 ESR1 FES HDAC10 HTRA2 IRF1 IRF7 LYN MAGEA2 MAGEA2B MAGEA3 MAGEA6 MAGED1 MYB NDNL2 NR3C1 NR4A1 NR4A3 PFDN5 PPP4C RNF4 SENP7 SERTAD1 SERTAD2 SETDB1 SIN3A SKI SMARCAD1 SPG7 STAT3 TRIM24 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2H UBE2I UBE2L3 UBE2N UBE2U VHL VIM YWHAQ ZNF10 ZNF133 ZNF140 ZNF197 ZNF354A ZNF382 ZNF420 ZNF496 ZNF689 ZNF74
Entrez ID		7699	10155
HPRD ID		04966	03445
Ensembl ID			ENSG00000130726
Uniprot IDs		P52738 Q05CP6	Q13263
PDB IDs			1FP0 2RO1 2YVR
Enriched GO Terms of Interacting Partners?		Negative Regulation Of DNA Demethylation Convergent Extension Involved In Axis Elongation Regulation Of Genetic Imprinting DNA Methylation Involved In Embryo Development Convergent Extension Negative Regulation Of Viral Release From Host Cell Regulation Of Viral Release From Host Cell Protein Sumoylation Embryonic Placenta Morphogenesis Axis Elongation Positive Regulation Of DNA Repair Positive Regulation Of Transcription Factor Import Into Nucleus Epithelial To Mesenchymal Transition DNA Methylation Regulation Of DNA Repair Positive Regulation Of Response To DNA Damage Stimulus Negative Regulation Of Viral Process Embryo Implantation DNA Modification Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of DNA Metabolic Process Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Mesenchymal Cell Development Embryonic Placenta Development Regulation Of Response To DNA Damage Stimulus Mesenchymal Cell Differentiation Developmental Growth Involved In Morphogenesis Positive Regulation Of DNA Metabolic Process Regulation Of Viral Process Positive Regulation Of Intracellular Protein Transport Transcription Initiation From RNA Polymerase II Promoter Regulation Of Protein Import Into Nucleus Placenta Development Regulation Of Protein Localization To Nucleus Mesenchyme Development Regulation Of Gene Expression, Epigenetic Protein Autophosphorylation Regulation Of Nucleocytoplasmic Transport DNA-templated Transcription, Initiation Female Pregnancy Positive Regulation Of Intracellular Transport Stem Cell Development Peptidyl-lysine Modification Regulation Of Intracellular Protein Transport Developmental Growth Stem Cell Differentiation Positive Regulation Of Protein Transport	Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated Regulation Of Gene Expression RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Protein K48-linked Ubiquitination RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Macromolecule Biosynthetic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Protein Polyubiquitination Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Protein Catabolic Process Cellular Metabolic Process Regulation Of Cellular Process Cellular Protein Catabolic Process Positive Regulation Of Metabolic Process Protein Ubiquitination Biosynthetic Process Protein Modification By Small Protein Conjugation Protein K11-linked Ubiquitination Cellular Macromolecule Catabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process
Tagcloud ?		alteration another arrays belonging cd34 clusters differentially discovery downregulated encoded enriched evolution familial fos hybridized leukemic libraries mdss mnda mononuclear myeloid overexpressed precise sporadic subtractive tags top unaffected underexpressed	accumulates aging becoming damaged depletion genomes il6 il8 ink4a insults kap1 knocked krab limits mediating mixture ois oncogene partially pathologies prevented profound reinforcing sasp secrete secretory senescence termed undergo
Tagcloud (Difference) ?		alteration another arrays belonging cd34 clusters differentially discovery downregulated encoded enriched evolution familial fos hybridized leukemic libraries mdss mnda mononuclear myeloid overexpressed precise sporadic subtractive tags top unaffected underexpressed	accumulates aging becoming damaged depletion genomes il6 il8 ink4a insults kap1 knocked krab limits mediating mixture ois oncogene partially pathologies prevented profound reinforcing sasp secrete secretory senescence termed undergo
Tagcloud (Intersection) ?